Metallothionein 1A
{{Short description|Protein found in humans}}
{{Infobox_gene}}
Metallothionein-1A is a protein that in humans is encoded by the MT1A gene.{{cite journal |vauthors=Karin M, Eddy RL, Henry WM, Haley LL, Byers MG, Shows TB | title = Human metallothionein genes are clustered on chromosome 16 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 81 | issue = 17 | pages = 5494–8 |date=Oct 1984 | pmid = 6089206 | pmc = 391732 | doi =10.1073/pnas.81.17.5494 | bibcode = 1984PNAS...81.5494K | doi-access = free }}{{cite journal |vauthors=Richards RI, Heguy A, Karin M | title = Structural and functional analysis of the human metallothionein-IA gene: differential induction by metal ions and glucocorticoids | journal = Cell | volume = 37 | issue = 1 | pages = 263–72 |date=Jun 1984 | pmid = 6327055 | doi =10.1016/0092-8674(84)90322-2 | doi-access = free }}{{cite web | title = Entrez Gene: MT1A metallothionein 1A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4489}}
References
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Further reading
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- {{cite journal |vauthors=Thirumoorthy N, Manisenthil Kumar KT, Shyam Sundar A, etal |title=Metallothionein: an overview. |journal=World Journal of Gastroenterology |volume=13 |issue=7 |pages=993–6 |year=2007 |pmid=17373731 |doi=10.3748/wjg.v13.i7.993|pmc=4146885 |doi-access=free }}
- {{cite journal |vauthors=Sutherland GR, Baker E, Callen DF, etal |title=The human metallothionein gene cluster is not disrupted in myelomonocytic leukemia. |journal=Genomics |volume=6 |issue=1 |pages=144–8 |year=1990 |pmid=2303255 |doi=10.1016/0888-7543(90)90459-8 }}
- {{cite journal |vauthors=Grider A, Bailey LB, Cousins RJ |title=Erythrocyte metallothionein as an index of zinc status in humans. |journal=Proceedings of the National Academy of Sciences of the United States of America |volume=87 |issue=4 |pages=1259–62 |year=1990 |pmid=2304897 |doi=10.1073/pnas.87.4.1259 | pmc=53453 |bibcode=1990PNAS...87.1259G |doi-access=free }}
- {{cite journal |vauthors=Le Beau MM, Diaz MO, Karin M, Rowley JD |title=Metallothionein gene cluster is split by chromosome 16 rearrangements in myelomonocytic leukaemia. |journal=Nature |volume=313 |issue=6004 |pages=709–11 |year=1985 |pmid=3856101 |doi=10.1038/313709a0 |bibcode=1985Natur.313..709L |s2cid=4321473 }}
- {{cite journal |vauthors=Hunziker PE, Kägi JH |title=Isolation and characterization of six human hepatic isometallothioneins. |journal=Biochemical Journal |volume=231 |issue=2 |pages=375–82 |year=1985 |pmid=4062903 |doi=10.1042/bj2310375| pmc=1152756 }}
- {{cite journal |vauthors=Armitage IM, Otvos JD, Briggs RW, Boulanger Y |title=Structure elucidation of the metal-binding sites in metallothionein by 113Cd NMR. |journal=Federation Proceedings |volume=41 |issue=13 |pages=2974–80 |year=1983 |pmid=7140998 }}
- {{cite journal |vauthors=Akintola DF, Sampson B, Fleck A |title=Development of an enzyme-linked immunosorbent assay for human metallothionein-1 in plasma and urine. |journal=The Journal of Laboratory and Clinical Medicine |volume=126 |issue=2 |pages=119–27 |year=1995 |pmid=7543551 }}
- {{cite journal |vauthors=Davis SR, McMahon RJ, Cousins RJ |title=Metallothionein knockout and transgenic mice exhibit altered intestinal processing of zinc with uniform zinc-dependent zinc transporter-1 expression. |journal=Journal of Nutrition |volume=128 |issue=5 |pages=825–31 |year=1998 |pmid=9566988 |doi=10.1093/jn/128.5.825|doi-access=free }}
- {{cite journal |vauthors=Simpkins C, Lloyd T, Li S, Balderman S |title=Metallothionein-induced increase in mitochondrial inner membrane permeability. |journal=Journal of Surgical Research |volume=75 |issue=1 |pages=30–4 |year=1998 |pmid=9614853 |doi=10.1006/jsre.1997.5241 }}
- {{cite journal |vauthors=Lau JC, Cherian MG |title=Developmental changes in hepatic metallothionein, zinc, and copper levels in genetically altered mice. |journal=Biochemistry and Cell Biology |volume=76 |issue=4 |pages=615–23 |year=1999 |pmid=10099782 |doi=10.1139/bcb-76-4-615 }}
- {{cite journal |vauthors=Levadoux M, Mahon C, Beattie JH, etal |title=Nuclear import of metallothionein requires its mRNA to be associated with the perinuclear cytoskeleton. |journal=Journal of Biological Chemistry |volume=274 |issue=49 |pages=34961–6 |year=2000 |pmid=10574972 |doi=10.1074/jbc.274.49.34961 |doi-access=free }}
- {{cite journal |vauthors=Garrett SH, Sens MA, Shukla D, etal |title=Metallothionein isoform 1 and 2 gene expression in the human prostate: downregulation of MT-1X in advanced prostate cancer. |journal=The Prostate |volume=43 |issue=2 |pages=125–35 |year=2000 |pmid=10754528 |doi=10.1002/(SICI)1097-0045(20000501)43:2<125::AID-PROS7>3.0.CO;2-S |s2cid=8768274 }}
- {{cite journal |vauthors=Campagne MV, Thibodeaux H, van Bruggen N, etal |title=Increased binding activity at an antioxidant-responsive element in the metallothionein-1 promoter and rapid induction of metallothionein-1 and -2 in response to cerebral ischemia and reperfusion. |journal=The Journal of Neuroscience |volume=20 |issue=14 |pages=5200–7 |year=2000 |pmid=10884303 |doi=10.1523/JNEUROSCI.20-14-05200.2000|pmc=6772313 }}
- {{cite journal |vauthors=Rahman MT, De Ley M |title=Metallothionein isogene transcription in red blood cell precursors from human cord blood. |journal=European Journal of Biochemistry |volume=268 |issue=3 |pages=849–56 |year=2001 |pmid=11168427 |doi=10.1046/j.1432-1327.2001.01947.x |doi-access=free }}
- {{cite journal |vauthors=Levadoux-Martin M, Hesketh JE, Beattie JH, Wallace HM |title=Influence of metallothionein-1 localization on its function. |journal=Biochemical Journal |volume=355 |issue=Pt 2 |pages=473–9 |year=2001 |pmid=11284736 |doi=10.1042/0264-6021:3550473 | pmc=1221760 }}
- {{cite journal |vauthors=Richarz AN, Brätter P |title=Speciation analysis of trace elements in the brains of individuals with Alzheimer's disease with special emphasis on metallothioneins. |journal=Analytical and Bioanalytical Chemistry |volume=372 |issue=3 |pages=412–7 |year=2002 |pmid=11939525 |doi=10.1007/s00216-001-1187-5 |s2cid=21611530 }}
- {{cite journal |vauthors=Minami T, Kubo K, Ichida S |title=Determination of metallothionein-1/metallothionein-2 ratios in the mouse liver and pancreas by capillary zone electrophoresis using a polyacrylamide-coated capillary at neutral pH. |journal=Journal of Chromatography B |volume=779 |issue=2 |pages=211–9 |year=2003 |pmid=12361735 |doi=10.1016/S1570-0232(02)00375-6}}
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