Michel C. Nussenzweig
{{Short description|Brazilian immunologist (born 1955)}}
{{Infobox scientist
| image = Nussenzweig 2015.1446150841.jpg
| image_size =
| alt =
| caption =
| birth_date = {{birth date and age|df=y |1955|02|10}}
| birth_place = São Paulo, Brazil
| fields = Immunology
Molecular Biology
| workplaces = The Rockefeller University
| education = {{ublist |The Rockefeller University (Ph.D., 1981) | New York University School of Medicine (M.D., 1982)}}
| alma_mater = New York University (B.A., 1975)
| spouse = Svetlana Mojsov
}}
Michel C. Nussenzweig (born 10 February 1955) is a professor and head of the Laboratory of Molecular Immunology at The Rockefeller University and a Howard Hughes Medical Institute investigator. He is a member of both the US National Academy of Medicine and the US National Academy of Sciences.
Education and career
Nussenzweig graduated summa cum laude with a B.A. degree from New York University College of Arts and Sciences in 1975. He earned a Ph.D. from The Rockefeller University in 1981 in cellular immunology, working in Zanvil A. Cohn’s laboratory with Ralph M. Steinman on groundbreaking studies of mouse dendritic cells.
As a Ph.D. student, Nussenzweig was the first to show that dendritic cells present foreign antigens to initiate T cell immunity.{{cite journal|last1=Nussenzweig|first1=M. C.|last2=Steinman|first2=R. M.|title=Contribution of dendritic cells to stimulation of the murine syngeneic mixed leukocyte reaction|journal=The Journal of Experimental Medicine|date=1 May 1980|volume=151|issue=5|pages=1196–1212|doi=10.1084/jem.151.5.1196|pmid=6445399|language=en|issn=0022-1007|pmc=2185855}} He also produced the first dendritic cell-specific monoclonal antibody and cloned the first dendritic cell receptor.{{cite journal|last1=Nussenzweig|first1=M C|last2=Steinman|first2=R M|last3=Witmer|first3=M D|last4=Gutchinov|first4=B|title=A monoclonal antibody specific for mouse dendritic cells|journal=Proceedings of the National Academy of Sciences of the United States of America|date=1 January 1982|volume=79|issue=1|pages=161–165|pmc=345682|issn=0027-8424|bibcode=1982PNAS...79..161N|pmid=6948298|doi=10.1073/pnas.79.1.161|doi-access=free}}
Nussenzweig received an M.D. from New York University School of Medicine in 1982 and completed his internship and residency in internal medicine, and a clinical fellowship in infectious diseases at Massachusetts General Hospital in 1985. From 1986 to 1989, he was a postdoctoral fellow in genetics in the Harvard Medical School laboratory of Philip Leder. Nussenzweig returned to The Rockefeller University as an assistant professor in 1990 and he became an associate professor in 1994, and a professor and senior physician in 1996. In 2013, he was named the first Zanvil A. Cohn and Ralph M. Steinman Professor.{{cite web|title=Heads of Laboratory: Michel C. Nussenzweig|url=http://www.rockefeller.edu/research/faculty/labheads/MichelNussenzweig/#content|website=The Rockefeller University|accessdate=16 Aug 2016}}{{cite web|title=Immunity and Tolerance|url=http://www.hhmi.org/research/immunity-and-tolerance|website=Howard Hughes Medical Institute|accessdate=16 Aug 2016}}
Summary of research achievements
Nussenzweig studies molecular aspects of the immune system’s adaptive and innate responses, using a combination of biochemistry, molecular biology, and genetics. Work on adaptive immunity focuses on B lymphocytes and antibodies to HIV-1, while work on innate immunity focuses on dendritic cells.{{cite journal|last1=Scheid|first1=Johannes F.|last2=Mouquet|first2=Hugo|last3=Feldhahn|first3=Niklas|last4=Seaman|first4=Michael S.|last5=Velinzon|first5=Klara|last6=Pietzsch|first6=John|last7=Ott|first7=Rene G.|last8=Anthony|first8=Robert M.|last9=Zebroski|first9=Henry|last10=Hurley|first10=Arlene|last11=Phogat|first11=Adhuna|last12=Chakrabarti|first12=Bimal|last13=Li|first13=Yuxing|last14=Connors|first14=Mark|last15=Pereyra|first15=Florencia|last16=Walker|first16=Bruce D.|last17=Wardemann|first17=Hedda|last18=Ho|first18=David|last19=Wyatt|first19=Richard T.|author20-link=John R. Mascola|last20=Mascola|first20=John R.|last21=Ravetch|first21=Jeffrey V.|last22=Nussenzweig|first22=Michel C.|title=Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals|journal=Nature|date=2 April 2009|volume=458|issue=7238|pages=636–640|doi=10.1038/nature07930|pmid=19287373|bibcode=2009Natur.458..636S|s2cid=4399760}} The laboratory has isolated and cloned human antibodies to HIV-1 and explored their roles in prevention and therapy. In clinical trials, a broadly neutralizing antibody isolated from an HIV-infected patient was shown to be safe and effective and to interfere with chronic infection in a way that traditional antiretroviral therapy does not.{{cite journal|last1=Halper-Stromberg|first1=Ariel|last2=Lu|first2=Ching-Lan|last3=Klein|first3=Florian|last4=Horwitz|first4=Joshua A.|last5=Bournazos|first5=Stylianos|last6=Nogueira|first6=Lilian|last7=Eisenreich|first7=Thomas R.|last8=Liu|first8=Cassie|last9=Gazumyan|first9=Anna|last10=Schaefer|first10=Uwe|last11=Furze|first11=Rebecca C.|last12=Seaman|first12=Michael S.|last13=Prinjha|first13=Rab|last14=Tarakhovsky|first14=Alexander|last15=Ravetch|first15=Jeffrey V.|last16=Nussenzweig|first16=Michel C.|title=Broadly Neutralizing Antibodies and Viral Inducers Decrease Rebound from HIV-1 Latent Reservoirs in Humanized Mice|journal=Cell|date=28 August 2014|volume=158|issue=5|pages=989–999|doi=10.1016/j.cell.2014.07.043|pmid=25131989|pmc=4163911}}{{cite journal|last1=Scheid|first1=Johannes F.|display-authors=etal|title=HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption|journal=Nature|date=28 July 2016|volume=535|issue=7613|pages=556–560|doi=10.1038/nature18929|pmid=27338952|pmc=5034582|bibcode=2016Natur.535..556S}} His research has led to the development of innovative vaccines against infectious diseases and new treatments for autoimmunity.{{cite journal|last1=Lu|first1=Ching-Lan|last2=Murakowski|first2=Dariusz K.|last3=Bournazos|first3=Stylianos|last4=Schoofs|first4=Till|last5=Sarkar|first5=Debolina|last6=Halper-Stromberg|first6=Ariel|last7=Horwitz|first7=Joshua A.|last8=Nogueira|first8=Lilian|last9=Golijanin|first9=Jovana|last10=Gazumyan|first10=Anna|last11=Ravetch|first11=Jeffrey V.|last12=Caskey|first12=Marina|last13=Chakraborty|first13=Arup K.|last14=Nussenzweig|first14=Michel C.|title=Enhanced clearance of HIV-1–infected cells by broadly neutralizing antibodies against HIV-1 in vivo|journal=Science|date=20 May 2016|volume=352|issue=6288|pages=1001–1004|doi=10.1126/science.aaf1279|pmid=27199430|language=en|issn=0036-8075|bibcode=2016Sci...352.1001L|pmc=5126967}}{{cite journal|last1=Schoofs|first1=Till|last2=Klein|first2=Florian|last3=Braunschweig|first3=Malte|last4=Kreider|first4=Edward F.|last5=Feldmann|first5=Anna|last6=Nogueira|first6=Lilian|last7=Oliveira|first7=Thiago|last8=Lorenzi|first8=Julio C. C.|last9=Parrish|first9=Erica H.|last10=Learn|first10=Gerald H.|last11=West|first11=Anthony P.|last12=Bjorkman|first12=Pamela J.|last13=Schlesinger|first13=Sarah J.|last14=Seaman|first14=Michael S.|last15=Czartoski|first15=Julie|last16=McElrath|first16=M. Juliana|last17=Pfeifer|first17=Nico|last18=Hahn|first18=Beatrice H.|last19=Caskey|first19=Marina|last20=Nussenzweig|first20=Michel C.|title=HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1|journal=Science|date=20 May 2016|volume=352|issue=6288|pages=997–1001|doi=10.1126/science.aaf0972|pmid=27199429|language=en|issn=0036-8075|bibcode=2016Sci...352..997S|pmc=5151174}}
Awards and honors
- American Association of Immunologists Meritorious Career Award, 2004{{Cite web |title=AAI-Thermo Fisher Meritorious Career Award|url=http://www.aai.org/Awards/Archive/Meritorious.html |access-date=14 July 2016 }}
- American Academy of Arts and Sciences, 2007{{cite web|title=Twelve Howard Hughes Medical Institute Scientists Elected to American Academy of Arts and Sciences|url=http://www.hhmi.org/news/twelve-howard-hughes-medical-institute-scientists-elected-american-academy-arts-and-sciences|website=Howard Hughes Medical Institute|accessdate=15 August 2016}}
- Lee C. Howley Sr. Prize for Arthritis Research, 2008{{Cite web |url=http://www.arthritis.org/arthritis-cure/for-researchers/howley-prize-for-arthritis-research/past-howley-prize-recipients.php |title=Past Howley Prize Recipients |access-date= 18 July 2016}}
- National Academy of Medicine, 2009{{cite web|title=Institute of Medicine Elects 65 New Members, Five Foreign Associates | url=http://www8.nationalacademies.org/onpinews/newsitem.aspx?RecordID=10122009a | website=News from The National Academies | accessdate=15 August 2016}}
- National Academy of Sciences, 2011{{Cite web |url= http://newswire.rockefeller.edu/?page=engine&id=1165 |title=Michel C. Nussenzweig elected to National Academy of Sciences |access-date=16 August 2016 |date=3 May 2011 }}
- Brazilian Academy of Sciences, 2011{{Cite web |url=http://www.abc.org.br/article.php3?id_article=1768 |title=Eleitos novos membros da ABC |date=16 December 2011 |language=Portuguese |trans-title=Newly Elected Members of the ABC |access-date=14 July 2016 }}
- Nobel Prize Lecture on behalf of Ralph Steinman, 2011{{cite web|title=Nobel Lecture 2011|url=https://www.nobelprize.org/prizes/medicine/2011/steinman/lecture/|website=The Official Site of the Nobel Prize|accessdate=18 September 2022}}
- Brazil Diaspora Prize, 2015{{Cite web |url=http://www.diasporabrasil.com.br/premio/sitepages/noticias.aspx?NoticiasID=4 |title=Prêmio Diáspora Brasil divulga vencedores |access-date= 16 August 2016 |website= |language=Portuguese}}
- Spanish Royal Academy, 2016{{Cite web |url=http://www.ranf.com/sesiones-y-actos/recepciones/2216-academico-honor-michel-c-nussenzweig.html
|title=Toma de Posesión de Académico de Honor del Excmo. Sr. D. Michel C. Nussenzweig|website=Real Academia Nacional de Farmacia |access-date=16 August 2016 |date=11 April 2016 |language=Spanish }}
- Rabbi Shai Shacknai Memorial Prize in Immunology and Cancer Research, 2016{{Cite web |title=The 2016 Rabbi Shai Shacknai Memorial Lecture in Immunology and Cancer Research |url=https://medicine.ekmd.huji.ac.il/He/Home/Lists/Events/Attachments/802/RabbiShacknaiMemorialLecture_05.06.2016.pdf |access-date=16 August 2016 |website=The Hebrew University of Jerusalem Faculty of Medicine}}
- Robert Koch Award, 2016{{Cite web |url= http://www.robert-koch-stiftung.de/index.php?article_id=300&clang=1 |title=With their outstanding research, laureates lay the foundation for understanding the way in which different immunological mechanisms function |date=22 June 2016 |access-date=18 July 2016 }}
- AAI-BioLegend Herzenberg Award, 2017{{Cite web|url=http://www.aai.org/Awards/Career-Awards/AAI-Herzenberg-Award/Past-Recipients.aspx|title=AAI-BioLegend Herzenberg Award Past Recipients|website=The American Association of Immunologists|access-date=7 March 2018}}
- Sanofi-Institut Pasteur Award, 2017{{Cite web|url=http://jem.rupress.org/announcement-2|title=JEM Editorial Board Co-Chair wins 2017 Sanofi-Institut Pasteur Award|date=12 December 2017|website=Journal of Experimental Medicine|access-date=5 March 2018}}
References
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Category:New York University College of Arts & Science alumni
Category:Howard Hughes Medical Investigators
Category:Members of the National Academy of Medicine
Category:Members of the United States National Academy of Sciences
Category:Members of the Brazilian Academy of Sciences