MicroRNA 495

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].

{{reflist}}

{{refbegin | 2}}

• {{cite journal |author9-link=Eva Y.-H. P. Lee |vauthors=Hwang-Verslues WW, Chang PH, Wei PC, Yang CY, Huang CK, Kuo WH, Shew JY, Chang KJ, Lee EY, Lee WH |title=miR-495 is upregulated by E12/E47 in breast cancer stem cells, and promotes oncogenesis and hypoxia resistance via downregulation of E-cadherin and REDD1 |journal=Oncogene |volume=30 |issue=21 |pages=2463–74 |year=2011 |pmid=21258409 |doi=10.1038/onc.2010.618 |doi-access=free }}
• {{cite journal |vauthors=Li Z, Cao Y, Jie Z, Liu Y, Li Y, Li J, Zhu G, Liu Z, Tu Y, Peng G, Lee DW, Park SS |title=miR-495 and miR-551a inhibit the migration and invasion of human gastric cancer cells by directly interacting with PRL-3 |journal=Cancer Lett. |volume=323 |issue=1 |pages=41–7 |year=2012 |pmid=22469786 |doi=10.1016/j.canlet.2012.03.029 }}
• {{cite journal |vauthors=Jiang X, Huang H, Li Z, He C, Li Y, Chen P, Gurbuxani S, Arnovitz S, Hong GM, Price C, Ren H, Kunjamma RB, Neilly MB, Salat J, Wunderlich M, Slany RK, Zhang Y, Larson RA, Le Beau MM, Mulloy JC, Rowley JD, Chen J |title=MiR-495 is a tumor-suppressor microRNA down-regulated in MLL-rearranged leukemia |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=109 |issue=47 |pages=19397–402 |year=2012 |pmid=23132946 |pmc=3511140 |doi=10.1073/pnas.1217519109 |bibcode=2012PNAS..10919397J |doi-access=free }}
• {{cite journal |vauthors=Chen SM, Chen HC, Chen SJ, Huang CY, Chen PY, Wu TW, Feng LY, Tsai HC, Lui TN, Hsueh C, Wei KC |title=MicroRNA-495 inhibits proliferation of glioblastoma multiforme cells by downregulating cyclin-dependent kinase 6 |journal=World J Surg Oncol |volume=11 |pages=87 |year=2013 |pmid=23594394 |pmc=3655862 |doi=10.1186/1477-7819-11-87 |doi-access=free }}
• {{cite journal |vauthors=Song L, Li Y, Li W, Wu S, Li Z |title=miR-495 enhances the sensitivity of non-small cell lung cancer cells to platinum by modulation of copper-transporting P-type adenosine triphosphatase A (ATP7A) |journal=J. Cell. Biochem. |volume=115 |issue=7 |pages=1234–42 |year=2014 |pmid=24038379 |doi=10.1002/jcb.24665 |s2cid=23587479 }}
• {{cite journal |vauthors=Formosa A, Markert EK, Lena AM, Italiano D, Finazzi-Agro' E, Levine AJ, Bernardini S, Garabadgiu AV, Melino G, Candi E |title=MicroRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b, miR-485-3p, miR-495 and miR-654-3p, mapped to the 14q32.31 locus, regulate proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells |journal=Oncogene |volume=33 |issue=44 |pages=5173–82 |year=2014 |pmid=24166498 |doi=10.1038/onc.2013.451 |s2cid=36638076 |doi-access=free }}
• {{cite journal |vauthors=Chu H, Chen X, Wang H, Du Y, Wang Y, Zang W, Li P, Li J, Chang J, Zhao G, Zhang G |title=MiR-495 regulates proliferation and migration in NSCLC by targeting MTA3 |journal=Tumour Biol. |volume=35 |issue=4 |pages=3487–94 |year=2014 |pmid=24293376 |doi=10.1007/s13277-013-1460-1 |s2cid=15816727 }}
• {{cite journal |vauthors=Xu Y, Ohms SJ, Li Z, Wang Q, Gong G, Hu Y, Mao Z, Shannon MF, Fan JY |title=Changes in the expression of miR-381 and miR-495 are inversely associated with the expression of the MDR1 gene and development of multi-drug resistance |journal=PLOS ONE |volume=8 |issue=11 |pages=e82062 |year=2013 |pmid=24303078 |pmc=3841137 |doi=10.1371/journal.pone.0082062 |bibcode=2013PLoSO...882062X |doi-access=free }}
• {{cite journal |vauthors=Lee S, Yoon DS, Paik S, Lee KM, Jang Y, Lee JW |title=microRNA-495 inhibits chondrogenic differentiation in human mesenchymal stem cells by targeting Sox9 |journal=Stem Cells Dev. |volume=23 |issue=15 |pages=1798–808 |year=2014 |pmid=24654627 |pmc=4103260 |doi=10.1089/scd.2013.0609 }}

{{refend}}

{{NLM content}}

{{gene-14-stub}}