Microbicide Trials Network

File:Microbicide Trials Network logo.png

The Microbicide Trials Network (MTN, 2006-2021) was a United States government-funded research organization working in the field of microbicides for sexually transmitted diseases.{{cite web |last1=Hillier |first1=Sharon |title=Thank you for these past 15 years |url=https://www.mtnstopshiv.org/thank-you-these-past-15-years |website=www.mtnstopshiv.org |publisher=Microbicide Trials Network |date=30 November 2021}}{{cite web |last1=Buhl |first1=Larry |title=NIH Restructures HIV Clinical Trial Networks; AIDS Director Touts Milestones |url=https://www.thebodypro.com/article/nih-hiv-clinical-trial-networks-diffenbach |website=thebodypro.com |publisher=HealthCentral |date=4 January 2021}} The MTN focused on research into microbicides which would prevent HIV infection. The MTN was a member of HANC. After its closure, partner organization HIV Prevention Trials Network took control of its projects.

Research

The MTN's notable research included various clinical trials.

The results of the CAPRISA 004 trial inspired the research of the MTN and the microbicide field.{{cite web |last1=Alcorn |first1=Keith |title=Tenofovir-based microbicide gel reduces risk of infection for women by 39% |url=https://www.aidsmap.com/news/jul-2010/tenofovir-based-microbicide-gel-reduces-risk-infection-women-39 |website=aidsmap.com |publisher=Aidsmap |language=en |date=19 July 2010}}

The Vaginal and Oral Interventions to Control the Epidemic (VOICE) found a vaginal gel containing an anti-HIV drug to be ineffective at preventing HIV transmission..{{cite web |url=http://news.sciencemag.org/sciencenow/2011/11/baffling-failure-of-vaginal-gel-.html |title=Baffling Failure of Vaginal Gel Laced With Anti-HIV Drug - ScienceNOW |first=Jon |last=Cohen |work=news.sciencemag.org |date=28 November 2011 |accessdate=6 March 2012 |url-status=dead |archiveurl=https://web.archive.org/web/20120206005045/http://news.sciencemag.org/sciencenow/2011/11/baffling-failure-of-vaginal-gel-.html |archivedate=6 February 2012 }}

The HOPE study tested dapivirine vaginal rings for HIV prevention in 1,456 study participants at 14 sites in Malawi, South Africa, Uganda and Zimbabwe.{{cite web |title=Most women use vaginal ring for HIV prevention in open-label study |url=https://www.nih.gov/news-events/news-releases/most-women-use-vaginal-ring-hiv-prevention-open-label-study |website=National Institutes of Health (NIH) |language=EN |date=23 July 2019}}

References

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