Mir-278 microRNA precursor family
{{Infobox rfam
| Name = mir-278
| image =
| width =
| caption =
| Symbol = mir-278
| AltSymbols =
| Rfam = RF00729
| miRBase =
| miRBase_family = 3
| RNA_type = microRNA
| Tax_domain = Eukaryota;
| GO =
| SO =
| CAS_number =
| EntrezGene =
| HGNCid =
| OMIM =
| PDB =
| RefSeq =
| Chromosome =
| Arm =
| Band =
| LocusSupplementaryData =
}}
In molecular biology mir-278 microRNA is a short RNA molecule belonging to a class of molecules referred to as microRNAs. These function to regulate the expression levels of other genes by several mechanisms, primarily binding to their target at its 3'UTR.
Mis- and altered expression in ''Drosophila''
miR-278 affects energy metabolism in the Drosophila melanogaster species. Elevated insulin production has been observed in miR-278 mutants, due to insulin resistance in the absence of this microRNA. miR-278 is now known to act through regulation of the expanded gene transcript, and most likely through further miR-278 targets as well.{{cite journal|vauthors=Teleman AA, Maitra S, Cohen SM | title=Drosophila lacking microRNA miR-278 are defective in energy homeostasis. | journal=Genes Dev | year= 2006 | volume= 20 | issue= 4 | pages= 417–22 | pmid=16481470 | doi=10.1101/gad.374406 | pmc=1369043 }}
Misexpression in the developing eye has been found to result in overgrowth, partially through apoptotic inhibition.{{cite journal|vauthors=Nairz K, Rottig C, Rintelen F, Zdobnov E, Moser M, Hafen E | title=Overgrowth caused by misexpression of a microRNA with dispensable wild-type function. | journal=Dev Biol | year= 2006 | volume= 291 | issue= 2 | pages= 314–24 | pmid=16443211 | doi=10.1016/j.ydbio.2005.11.047 | url=https://pubmed.ncbi.nlm.nih.gov/16443211 | doi-access= }} There is a single base substitution which blocks the gain-of-function phenotype, indicating the acquisition of novel functions by misexpressed miRNAs which bring about unscheduled cell proliferation in vivo. This is reflective of a microRNA potential in the promotion of tumour formation.
See also
References
{{reflist}}
Further reading
- {{Cite journal
| last1 = Yu | first1 = J. -Y.
| last2 = Reynolds | first2 = S. H.
| last3 = Hatfield | first3 = S. D.
| last4 = Shcherbata | first4 = H. R.
| last5 = Fischer | first5 = K. A.
| last6 = Ward | first6 = E. J.
| last7 = Long | first7 = D.
| last8 = Ding | first8 = Y.
| last9 = Ruohola-Baker | first9 = H.
| doi = 10.1242/dev.025999
| title = Dicer-1-dependent Dacapo suppression acts downstream of Insulin receptor in regulating cell division of Drosophila germline stem cells
| journal = Development
| volume = 136
| issue = 9
| pages = 1497–1507
| year = 2009
| pmid = 19336466
| pmc =2674257
}}
External links
- {{Rfam|id=RF00729|name=mir-278 microRNA precursor family}}
{{MiRNA precursor families}}
{{genetics-stub}}