Miratul Muqit
{{short description|British neurologist}}
{{Use dmy dates|date=April 2022}}
{{Infobox person
| name = Miratul Muqit
| image =
| birth_date = 1973
| birth_place = Glasgow, Scotland
| alma_mater = University of Edinburgh, Harvard University, University College London
| occupation = Consultant Neurologist, Professor
| organization = University of Dundee
| known_for = Contributions to the study of PINK1 in Parkinson’s disease
| website = https://www.ppu.mrc.ac.uk/research/principal-investigator/miratul-muqit
}}
Miratul Muqit FRSE{{Cite web|date=2020-08-24|title=Professor Miratul Muqit FRSE|url=https://www.rse.org.uk/fellow/miratul-muqit/|access-date=2020-08-27|website=The Royal Society of Edinburgh|language=en-GB}} FMedSci is a British neurologist and a Programme Lead at the MRC Protein Phosphorylation and Ubiquitylation Unit (MRCPPU) in the School of Life Sciences at the University of Dundee.{{Cite web|last=MMuqit|date=2013-09-02|title=Professor Miratul Muqit FRSE|url=https://www.lifesci.dundee.ac.uk/people/miratul-muqit|access-date=2020-08-27|website=School of Life Sciences|language=en}} His research focuses on the study of the PINK1 gene, mutations in which are a major cause of Parkinson's disease.{{Cite web|last=|first=|date=|title=Miratul Muqit|url=https://www.ppu.mrc.ac.uk/research/principal-investigator/miratul-muqit|archive-url=|archive-date=|access-date=2020-07-15|website=ppu.mrc.ac.uk}}
Education and career
Muqit studied medicine at the University of Edinburgh and graduated with Honours in 1997.{{Cite web|title=Edinburgh University|url=https://www.heraldscotland.com/news/12314784.edinburgh-university/|access-date=2020-08-27|website=HeraldScotland|language=en}} During his studies he became interested in neurodegenerative diseases, and in 2000 he was awarded a Kennedy scholarship{{Cite web|title=Kennedy Memorial Trust|url=https://www.kennedytrust.org.uk/|access-date=2020-08-27|website=www.kennedytrust.org.uk}} at Harvard University which he completed within a year of study.{{Cite web|last=|first=|date=|title=Harvard BBS PhD Program|url=https://www.hms.harvard.edu/dms/bbs/|archive-url=|archive-date=|access-date=2020-08-20|website=hms.harvard.edu}} His interest in neurodegeneration led him to study for a PhD in University College London’s Institute of Neurology, awarded to him in 2007.{{Cite web|last=|first=|date=|title=Principal investigator|url=https://www.ppu.mrc.ac.uk/research/principal-investigator/biography/miratul-muqit|archive-url=|archive-date=|access-date=2020-08-27|website=ppu.mrc.ac.uk}}{{Cite web|last=|first=|date=|title=Miratul Muqit|url=https://www.linkedin.com/in/miratul-muqit-6256b22b/|archive-url=|archive-date=|access-date=2020-07-15|website=Linked In}}{{Cite web|last=|first=|date=2020-04-11|title=World Parkinson's Day 2020 – Q&A with Professor Miratul Muqit|url=https://blogs.royalsociety.org/publishing/world-parkinsons-day-2020-with-miratul-muqit/|archive-url=|archive-date=|access-date=2020-08-27|website=The Royal Society Blog}}
He also received clinical training in medicine and neurology at the Hammersmith Hospital and the National Hospital for Neurology and Neurosurgery in London.
He joined the MRC PPU at the University of Dundee in 2008 and has worked there since combining laboratory research and clinical work as a Consultant Neurologist specialising in Movement Disorders.{{Cite web|title=Miratul Muqit, MD, PhD|url=https://www.michaeljfox.org/researcher/miratul-muqit-md-phd|access-date=2020-08-27|website=The Michael J. Fox Foundation for Parkinson's Research {{!}} Parkinson's Disease|language=en}} He was appointed Professor of Experimental Neurology in October 2018.{{Cite web|last=amycameron|date=2018-10-23|title=Professorships for Kim Dale and Miratul Muqit|url=https://www.lifesci.dundee.ac.uk/news/2018/oct/23/professorships-kim-dale-and-miratul-muqit|access-date=2020-08-27|website=School of Life Sciences|language=en}}
Research
Muqit's research focuses on the protein PINK1, study of which he began during his PhD in UCL. He is credited as a major contributor to the discovery of PINK1 mutations as a cause of Parkinson's disease, and he has been working on it ever since.{{Cite web|title=Scopus preview - Scopus - Author details (Muqit, Miratul M.K.)|url=https://www.scopus.com/authid/detail.uri?authorId=55393007300|access-date=2020-08-27|website=www.scopus.com}}
PINK1 is a kinase which normally senses damaged mitochondria and targets them for destruction, and mutations which interrupt its function will induce Parkinson's disease. Much of his research focuses on characterising PINK1 to understand its signalling pathway and the effects of it and its mutations on the cell, in order to help find treatments for Parkinson's Disease.{{Cite journal|last1=McWilliams|first1=Thomas G|last2=Muqit|first2=Miratul MK|date=2017-04-22|title=PINK1 and Parkin: emerging themes in mitochondrial homeostasis|journal=Current Opinion in Cell Biology|language=en|volume=45|pages=83–91|doi=10.1016/j.ceb.2017.03.013|pmid=28437683|doi-access=free}}
His research team at the university of Dundee has already discovered substrates of PINK1 such as Parkin and Ubiquitin, which have helped to clarify the function of this kinase. They have also made an effort to understand the mechanisms of activation and regulation of PINK1.
Impact
Muqit's research on Parkinson's and other neurological diseases has been cited by the larger scientific community over 10000 times{{Cite web|title=Miratul Muqit - Google Scholar|url=https://scholar.google.co.uk/citations?user=ziFzGeoAAAAJ&hl=en|access-date=2020-08-27|website=scholar.google.co.uk}}
Muqit is a member of the scientific advisory board of Mitokinin Inc.{{Cite web|title=About Us|url=https://www.mitokinin.com/about-us/|access-date=2020-08-27|website=Mitokinin|language=en-US}} He was formerly on the scientific advisory board of Amgen Inc.
His work was also covered widely on media including TV news, Scotland Tonight, where he was asked for his professional take on the subject.{{Cite web|last=|first=|date=|title=Scotland tonight tweet|url=https://twitter.com/scotlandtonight/status/1060280317444063235|archive-url=|archive-date=|access-date=2020-08-27|website=Twitter|language=en}}
Awards
- Queen Square Prize in Neurology (2006){{Cite web|last=|first=|date=2007|title=Queen Square Alumnus Association Newsletter number 29|url=http://ucl-ur.goodstudy.me/static__aHR0cHM6Ly93d3cudWNsLmFjLnVrfGh0dHBzOi8vd3d3LnVjbC5hYy51aw==/ion/sites/ion/files/queen_square_alumnus_association_newsletter_old_edition_-_issue_29.pdf|archive-url=|archive-date=|access-date=2020-08-27|website=}}
- Wellcome Trust Intermediate Clinical Fellowship (2008)
- Wellcome Trust Senior Fellowship in Clinical Science (2013)
- Linacre Prize Lecture from the Royal College of Physicians (2013){{Cite web|last=SHussain|date=2013-12-13|title=Royal College of Physicians honour for Miratul Muqit|url=https://www.lifesci.dundee.ac.uk/news/2013/dec/13/royal-college-physicians-honour-miratul-muqit|access-date=2020-08-27|website=School of Life Sciences|language=en}}
- Fellow of the Royal College of Physicians (2016){{Cite web|last=|first=|date=|title=Miratul Muqit elected Fellow of the Royal College of Physicians|url=https://www.ppu.mrc.ac.uk/news/miratul-muqit-elected-fellow-royal-college-physicians|archive-url=|archive-date=|access-date=2020-08-27|website=ppu.mrc.ac.uk}}
- European Molecular Biology Organisation(EMBO) Young Investigator Programme (2016){{Cite web|title=Find an EMBO Young Investigator / EMBO Installation Grantee / EMBO Global Investigator|url=https://yip-search.embo.org/#/yip/2698|access-date=2020-08-27|website=yip-search.embo.org}}
- Graham Bull Prize in Clinical Science & Goulstonian Lecture of the Royal College of Physicians (RCP) (2018){{Cite web|last=Dundee|first=University of|title=Dundee Clinician Scientist Receives Prestigious Medical Prize : News|url=https://www.dundee.ac.uk/news/2017/dundee-clinician-scientist-receives-prestigious-medical-prize-.php|access-date=2020-08-27|website=University of Dundee|language=en}}
- Royal Society Francis Crick Medal and Lecture (2018){{Cite web|title=Francis Crick Medal and Lecture {{!}} Royal Society|url=https://royalsociety.org/grants-schemes-awards/awards/francis-crick-lecture/|access-date=2020-08-27|website=royalsociety.org|language=en-gb}}
- Brian Cox Prize in public engagement (2019){{Cite web|last=amycameron|date=2020-01-15|title=Brian Cox Prize - Engaged Researcher|url=https://www.lifesci.dundee.ac.uk/awards/brian-cox-prize-engaged-researcher|access-date=2020-08-27|website=School of Life Sciences|language=en}}
- Fellow of the Royal Society of Edinburgh (2020)
- Fellow of the Academy of Medical Sciences (2023)
References
{{reflist}}
External links
- {{google scholar id|ziFzGeoAAAAJ}}
{{Authority control}}
{{DEFAULTSORT:Muqit, Miratul}}
Category:Academics of the University of Dundee