Mitochondrial pyruvate carrier
The mitochondrial pyruvate carriers are composed of:{{Cite journal |last=McCommis |first=Kyle S. |last2=Finck |first2=Brian N. |date=15 March 2015 |title=Mitochondrial pyruvate transport: a historical perspective and future research directions |journal=Biochemical Journal |volume=466 |issue=3 |pages=443–454 |doi=10.1042/BJ20141171 |pmc=4464838 |pmid=25748677}}{{Cite web |title=SLC54 Mitochondrial pyruvate carriers {{!}} Transporters {{!}} IUPHAR/BPS Guide to PHARMACOLOGY |url=https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1006 |access-date=3 December 2023 |website=www.guidetopharmacology.org}}
The pyruvate carriers are involved in mitochondrial metabolism but it is possible to compensate for their loss of function.{{Cite journal |last=Bender |first=Tom |last2=Martinou |first2=Jean-Claude |date=1 October 2016 |title=The mitochondrial pyruvate carrier in health and disease: To carry or not to carry? |url=https://www.sciencedirect.com/science/article/pii/S0167488916300076 |journal=Biochimica et Biophysica Acta (BBA) - Molecular Cell Research |volume=1863 |issue=10 |pages=2436–2442 |doi=10.1016/j.bbamcr.2016.01.017 |issn=0167-4889 |pmid=26826034|url-access=subscription }} They have been studied for a role in cardiac stress adaption.{{Cite journal |last=Zhang |first=Yuan |last2=Taufalele |first2=Paul V. |last3=Cochran |first3=Jesse D. |last4=Robillard-Frayne |first4=Isabelle |last5=Marx |first5=Jonas Maximilian |last6=Soto |first6=Jamie |last7=Rauckhorst |first7=Adam J. |last8=Tayyari |first8=Fariba |last9=Pewa |first9=Alvin D. |last10=Gray |first10=Lawrence R. |last11=Teesch |first11=Lynn M. |last12=Puchalska |first12=Patrycja |last13=Funari |first13=Trevor R. |last14=McGlauflin |first14=Rose |last15=Zimmerman |first15=Kathy |date=November 2020 |title=Mitochondrial pyruvate carriers are required for myocardial stress adaptation |journal=Nature Metabolism |language=en |volume=2 |issue=11 |pages=1248–1264 |doi=10.1038/s42255-020-00288-1 |issn=2522-5812 |pmc=8015649 |pmid=33106689 |last16=Kutschke |first16=William J. |last17=Cassier |first17=Thomas |last18=Hitchcock |first18=Shannon |last19=Lin |first19=Kevin |last20=Kato |first20=Kevin M. |last21=Stueve |first21=Jennifer L. |last22=Haff |first22=Lauren |last23=Weiss |first23=Robert M. |last24=Cox |first24=James E. |last25=Rutter |first25=Jared |last26=Taylor |first26=Eric B. |last27=Crawford |first27=Peter A. |last28=Lewandowski |first28=E. Douglas |last29=Des Rosiers |first29=Christine |last30=Abel |first30=E. Dale}}