Mitochondrial ribosomal protein L41
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
39S ribosomal protein L41, mitochondrial is a protein that in humans is encoded by the MRPL41 gene.{{cite journal |vauthors=Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T | title = The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders | journal = Genomics | volume = 77 | issue = 1–2 | pages = 65–70 |date=Sep 2001 | pmid = 11543634 | doi = 10.1006/geno.2001.6622 }}{{cite web | title = Entrez Gene: MRPL41 mitochondrial ribosomal protein L41| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64975}}
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the YmL27 ribosomal protein family.
References
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Further reading
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- {{cite journal |vauthors=Goldschmidt-Reisin S, Kitakawa M, Herfurth E, etal |title=Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences. |journal=J. Biol. Chem. |volume=273 |issue= 52 |pages= 34828–36 |year= 1999 |pmid= 9857009 |doi=10.1074/jbc.273.52.34828 |doi-access=free }}
- {{cite journal |vauthors=Koc EC, Burkhart W, Blackburn K, etal |title=The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. |journal=J. Biol. Chem. |volume=276 |issue= 47 |pages= 43958–69 |year= 2001 |pmid= 11551941 |doi= 10.1074/jbc.M106510200 |doi-access= free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Zhang Z, Gerstein M |title=Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome. |journal=Genomics |volume=81 |issue= 5 |pages= 468–80 |year= 2003 |pmid= 12706105 |doi=10.1016/S0888-7543(03)00004-1 }}
- {{cite journal |vauthors=Humphray SJ, Oliver K, Hunt AR, etal |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 | pmc=2734081 |bibcode=2004Natur.429..369H }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Chintharlapalli SR, Jasti M, Malladi S, etal |title=BMRP is a Bcl-2 binding protein that induces apoptosis. |journal=J. Cell. Biochem. |volume=94 |issue= 3 |pages= 611–26 |year= 2005 |pmid= 15547950 |doi= 10.1002/jcb.20292 |s2cid=23940695 }}
- {{cite journal |vauthors=Yoo YA, Kim MJ, Park JK, etal |title=Mitochondrial ribosomal protein L41 suppresses cell growth in association with p53 and p27Kip1. |journal=Mol. Cell. Biol. |volume=25 |issue= 15 |pages= 6603–16 |year= 2005 |pmid= 16024796 |doi= 10.1128/MCB.25.15.6603-6616.2005 | pmc=1190350 }}
- {{cite journal |vauthors=Kim MJ, Yoo YA, Kim HJ, etal |title=Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21(WAF1/CIP1). |journal=Biochem. Biophys. Res. Commun. |volume=338 |issue= 2 |pages= 1179–84 |year= 2006 |pmid= 16256947 |doi= 10.1016/j.bbrc.2005.10.064 }}
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{{GeneticTranslation}}
{{Ribosome subunits}}
{{gene-9-stub}}
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