Mitochondrial translational release factor 1
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Mitochondrial translational release factor 1, also known as MTRF1 is a human gene.{{cite journal |vauthors=Zhang Y, Spremulli LL | title = Identification and cloning of human mitochondrial translational release factor 1 and the ribosome recycling factor | journal = Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression | volume = 1443 | issue = 1–2 | pages = 245–50 |date=November 1998 | pmid = 9838146 | doi = 10.1016/S0167-4781(98)00223-1 }}{{cite journal |vauthors=Hansen LL, Jørgensen R, Justesen J | title = Assignment of the human mitochondrial translational release factor 1 (MTRF1) to chromosome 13q14.1→q14.3 and of the human mitochondrial ribosome recycling factor (MRRF) to chromosome 9q32→q34.1 with radiation hybrid mapping | journal = Cytogenetics and Cell Genetics | volume = 88 | issue = 1–2 | pages = 91–2 | year = 2000 | pmid = 10773675 | doi = 10.1159/000015494 | s2cid = 1354562 }}
The protein encoded by this gene directs the termination of translation in response to the peptide chain termination codons. Initially thought to have a role in the termination of mitochondria protein synthesis. mtRF1 has been hypothesized to recognize non-standard stop codons AGA and AGG in vertebrates. Alternatively, based on detailed 3D modelling, it has been proposed to recognize stalled ribosomes in which a tRNA is still bound to the peptide chain, but in which the A-site of the ribosome is empty.
References
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Further reading
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- {{cite journal |vauthors=Nozaki Y, Matsunaga N, Ishizawa T, etal |title=HMRF1L is a human mitochondrial translation release factor involved in the decoding of the termination codons UAA and UAG. |journal=Genes Cells |volume=13 |issue= 5 |pages= 429–38 |year= 2008 |pmid= 18429816 |doi= 10.1111/j.1365-2443.2008.01181.x |s2cid=21204094 |doi-access=free }}
- {{cite journal |vauthors=Dunham A, Matthews LH, Burton J, etal |title=The DNA sequence and analysis of human chromosome 13. |journal=Nature |volume=428 |issue= 6982 |pages= 522–8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379 |pmc=2665288 |bibcode=2004Natur.428..522D }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Research |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 |pmc=528928 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nature Genetics |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proceedings of the National Academy of Sciences |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Soleimanpour-Lichaei HR, Kühl I, Gaisne M, etal |title=mtRF1a is a human mitochondrial translation release factor decoding the major termination codons UAA and UAG. |journal=Molecular Cell |volume=27 |issue= 5 |pages= 745–57 |year= 2007 |pmid= 17803939 |doi= 10.1016/j.molcel.2007.06.031 |pmc=1976341 }}
- {{cite journal |vauthors=Young DJ, Edgar CD, Murphy J, etal | title= Bioinformatic, structural, and functional analyses support release factor-like MTRF1 as a protein able to decode nonstandard stop codons beginning with adenine in vertebrate mitochondria. | journal=RNA |volume= 16 |pages= 1146–55 |year= 2010 |pmid= 20421313 |doi=10.1261/rna.1970310 |issue=6 |pmc=2874167}}
- {{cite journal|last=Huynen, MA|first=Martijn|author2=Duarte I |author3=Chrzanowska-Lightowlers ZM |author4=Nabuurs SB. |title=Structure based hypothesis of a mitochondrial ribosome rescue mechanism.|journal=Biology Direct|date=8 May 2012|volume=7|issue=1|pages=14|doi=10.1186/1745-6150-7-14|pmid=22569235|pmc=3418547 |doi-access=free }}
- {{cite journal|last=Lind |first=C |author2=Sund J| author3=Åqvist J| title=Codon-reading specificities of mitochondrial release factors and translation termination at non-standard stop codons.|journal=Nature Communications |year=2013|doi=10.1038/ncomms3940|volume=4|page=2940 |pmid=24352605 |bibcode=2013NatCo...4.2940L |doi-access=free}}
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Category:Genes on human chromosome 13
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