Monometacrine

{{Short description|Abandoned antidepressant}}

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| CAS_number = 4757-49-7

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| PubChem = 145765

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| ChemSpiderID = 128589

| UNII = 3FDC82890Y

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| ChEMBL = 2104752

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| synonyms = Desmethyldimetacrine; Nordimetacrine; N-Desmethyldimetacrine; SD-735; NSC-100296

| IUPAC_name = 3-(9,9-dimethylacridin-10-yl)-N-methylpropan-1-amine

| C=19 | H=24 | N=2

| SMILES = CC1(C2=CC=CC=C2N(C3=CC=CC=C31)CCCNC)C

| StdInChI = 1S/C19H24N2/c1-19(2)15-9-4-6-11-17(15)21(14-8-13-20-3)18-12-7-5-10-16(18)19/h4-7,9-12,20H,8,13-14H2,1-3H3

| StdInChIKey = PGSOFANFWNSSRA-UHFFFAOYSA-N

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Monometacrine ({{Abbrlink|INN|International Nonproprietary Name}}; developmental code name SD-735), also known as desmethyldimetacrine, is a drug of the tricyclic family described as an antidepressant which was never marketed.{{cite book | vauthors = Elks J | title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies | publisher=Springer US | year=2014 | isbn=978-1-4757-2085-3 | url=https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA835 | access-date=20 October 2024 | page=835}}{{cite book | vauthors = Negwer M, Scharnow HG | title=Organic-chemical Drugs and Their Synonyms: An International Survey | publisher=Wiley-VCH | issue=v. 3 | year=2001 | isbn=978-3-527-30247-5 | url=https://books.google.com/books?id=zmpqAAAAMAAJ | access-date=20 October 2024 | page=1788}}{{cite web | title= Monometacrine | work = Inxight Drugs | publisher = National Center for Advancing Translational Sciences (NCATS) | url=https://drugs.ncats.io/drug/3FDC82890Y | access-date=20 October 2024}} It was first described in the literature by 1966. The drug is the N-desmethyl analogue of dimetacrine and is a metabolite of dimetacrine.