Morforex

{{Short description|Non-marketed appetite suppressant drug}}

{{Drugbox

| IUPAC_name = 4-[2-[(α-Methylphenethyl)amino]ethyl]morpholine

| image = Morforex.svg

| CAS_number = 41152-17-4

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = O9J6ITY8UX

| ATC_prefix = None

| ATC_suffix =

| PubChem = 3047774

| DrugBank =

| ChemSpiderID = 2310095

| chemical_formula =

| C=15 | H=24 | N=2 | O=1

| SMILES = CC(Cc1ccccc1)NCCN2CCOCC2

| StdInChI = 1S/C15H24N2O/c1-14(13-15-5-3-2-4-6-15)16-7-8-17-9-11-18-12-10-17/h2-6,14,16H,7-13H2,1H3

| StdInChIKey = ISEKMORYCCULAL-UHFFFAOYSA-N

| bioavailability =

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Morforex (INN; Bo 637), also referable to as N-morpholinoethylamphetamine, is an anorectic which was never marketed.{{cite book| vauthors = Ganellin CR, Triggle DJ |title=Dictionary of Pharmacological Agents|url=https://books.google.com/books?id=A0THacd46ZsC&pg=PA1377|date=21 November 1996|publisher=CRC Press|isbn=978-0-412-46630-4|pages=1377–}}{{cite book|author=World Health Organization|title=International Nonproprietary Names (INN) for Pharmaceutical Substances|url=https://books.google.com/books?id=HcogPwAACAAJ|year=2000|publisher=World Health Organization|isbn=978-0-11-986227-0}}

It produces amphetamine as an active metabolite.{{cite book| vauthors = Goodwin BL |title=Handbook of Biotransformations of Aromatic Compounds|url=https://books.google.com/books?id=luttauRomC8C&pg=SL13-PA98|date=10 November 2004|publisher=CRC Press|isbn=978-0-203-64196-5|pages=13–}}

Synthesis

File:Morforex synthesis.svg

Amphetamine is reacted with N-Chloroethylmorpholine [3240-94-6] in the presence of IPA solvent.

See also

References

{{Reflist|2}}

{{Anorectics}}

{{Stimulants}}

{{Monoamine releasing agents}}

{{Phenethylamines}}

Category:Substituted amphetamines

Category:Anorectics

Category:4-Morpholinyl compounds

Category:Norepinephrine-dopamine releasing agents

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