Mycobacterium microti
{{Short description|Species of bacterium}}
{{Speciesbox
| taxon = Mycobacterium microti
| authority = Reed 1957, ATCC 19422
}}
Mycobacterium microti is a member of the Mycobacterium tuberculosis complex (MTBC) known as the 'Vole bacillus', first described as a pathogen of field voles in England.{{Cite journal|title = Tuberculosis in wild voles|last = Wells|first = A Q|date = 1937|journal = Lancet| volume=229 | issue=5934 | page=1221 |doi = 10.1016/S0140-6736(00)83505-9| s2cid=2364438 }}
Description
Gram-positive, nonmotile, acid-fast rods.
Colony characteristics
- Variable colony morphology, buff in colour, either rough or smooth.
Physiology
- Slow growth on glycerol-free egg media at 37 °C often requiring incubation for 28–60 days. May adapt tolerance to glycerol. May fail to grow in liquid media.
- Usually susceptible to the first line anti tuberculosis antibiotics isoniazid, ethambutol, rifampin, streptomycin and pyrazinamide.
Differential characteristics
Commercially available nucleic acid hybridisation assays are widely used to identify members of the M. tuberculosis complex..
Differentiation between individual members of the M tuberculosis complex is possible using a variety of molecular techniques, and individual strains within a species may be further distinguished using a variety of molecular typing methods.
Pathogenesis
Cause of naturally acquired generalized tuberculosis in voles and other mammals, including cats and new world camelids such as llamas. Human infections are rare, but do occur in both immunocompromised and apparently immunocompetent patients.{{Cite journal|url = https://www.cdc.gov/EID/content/13/12/1924.htm|title = Human and animal infections with Mycobacterium microti, Scotland|last = Emmanuel|first = FX|date = Dec 2007|journal = Emerg Infect Dis|doi = 10.3201/eid1312.061536|pmid = 18258049|access-date = 26 August 2015|volume=13|issue = 12|pages=1924–1927|pmc = 2876740}}{{Cite journal|title = Diagnosis of Mycobacterium microti infections among humans by using novel genetic markers|last = van Soolingen|first = D|date = Jul 1998|journal = J Clin Microbiol|doi = 10.1128/JCM.36.7.1840-1845.1998|pmid = 9650922|pmc=104938|volume=36|issue = 7|pages=1840–5}}
Type strain
Strain ATCC 19422 = CIP 104256 = NCTC 8710.
References
{{Reflist}}
{{refbegin}}
- {{cite book |last=Reed |first=G. |chapter=Genus Mycobacterium (species affecting warm-blooded animals except those causing leprosy) |editor-first=R.S. |editor-last=Breed |editor2-first=E.G.D. |editor2-last=Murray |editor3-first=N.R. |editor3-last=Smith |title=Bergey's Manual of Determinative Bacteriology |url=https://archive.org/details/bergeysmanualofd1957amer |publisher=Williams & Wilkins |location=Baltimore |year=1957 |pages=[https://archive.org/details/bergeysmanualofd1957amer/page/703 703–4] |edition=7th }}
- {{cite journal |vauthors=van Soolingen D, van der Zanden AG, de Haas PE, etal |title=Diagnosis of Mycobacterium microti infections among humans by using novel genetic markers |journal=J. Clin. Microbiol. |volume=36 |issue=7 |pages=1840–5 |date=July 1998 |doi=10.1128/JCM.36.7.1840-1845.1998 |pmid=9650922 |pmc=104938 |url=}}
- {{cite web |title=Mycobacterium microti |work=NCBI Taxonomy Browser |url=https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=1806 |id=1806}}
{{refend}}
External links
- [https://bacdive.dsmz.de/strain/135717 Type strain of Mycobacterium microti at BacDive - the Bacterial Diversity Metadatabase]
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{{DEFAULTSORT:Mycobacterium Microti}}
Category:Bacteria described in 1957
{{Mycobacterium-stub}}