Mycobactin
{{Short description|Siderophore used by members of the genus Mycobacterium}}
Mycobactin is a siderophore used by members of the genus Mycobacterium to shuttle free extracellular iron ions into the cytoplasm of mycobacterial cells.{{cite journal|title=Analyses of MbtB, MbtE, and MbtF Suggest Revisions to the Mycobactin Biosynthesis Pathway in Mycobacterium tuberculosis|journal=Journal of Bacteriology |volume=194|issue=11|pages=2809–18|doi=10.1128/JB.00088-12 |pmid=22447909|year=2012|last1=McMahon|first1=M. D.|last2=Rush|first2=J. S.|last3=Thomas|first3=M. G. |pmc=3370630}} The pathogen M. tuberculosis can synthesize its own mycobactin for this purpose, however there are other mycobacteria such as M. avium subspecies paratuberculosis that cannot produce this siderophore and thus it must be supplied to cultivate this organism in the lab or in host organism.{{cite journal|title=Lack of mycobactin dependence of mycobacteria isolated on Middlebrook 7H11 from clinical cases of ovine paratuberculosis|journal=Veterinary Microbiology|volume=45|issue=2–3|pages=211–7|doi=10.1016/0378-1135(95)00037-B|pmid=7571372|year=1995|last1=Adúriz|first1=J.J.|last2=Juste|first2=R.A.|last3=Cortabarria|first3=N.}}{{Cite journal |last=Dane |first=Hannah |last2=Stewart |first2=Linda D |last3=Grant |first3=Irene R |date=2022-12-13 |title=Culture of Mycobacterium avium subsp. paratuberculosis: challenges, limitations and future prospects |journal=Journal of Applied Microbiology |volume=134 |issue=1 |doi=10.1093/jambio/lxac017 |issn=1365-2672|doi-access=free|pmid=36626735}}
References
{{Reflist}}