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NAP1L4

{{Short description|Protein-coding gene in the species Homo sapiens}}

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Nucleosome assembly protein 1-like 4 is a protein that in humans is encoded by the NAP1L4 gene.{{cite journal | vauthors = Hu RJ, Lee MP, Johnson LA, Feinberg AP | title = A novel human homologue of yeast nucleosome assembly protein, 65 kb centromeric to the p57KIP2 gene, is biallelically expressed in fetal and adult tissues | journal = Hum Mol Genet | volume = 5 | issue = 11 | pages = 1743–8 |date=Mar 1997 | pmid = 8923002 | doi =10.1093/hmg/5.11.1743 | doi-access = free }}{{cite web | title = Entrez Gene: NAP1L4 nucleosome assembly protein 1-like 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4676}}

This gene encodes a member of the nucleosome assembly protein (NAP) family which can interact with both core and linker histones. It can shuttle between the cytoplasm and nucleus, suggesting a role as a histone chaperone. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer.

References

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Further reading

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  • {{cite journal |vauthors=Rodriguez P, Munroe D, Prawitt D, etal |title=Functional characterization of human nucleosome assembly protein-2 (NAP1L4) suggests a role as a histone chaperone. |journal=Genomics |volume=44 |issue= 3 |pages= 253–65 |year= 1997 |pmid= 9325046 |doi= 10.1006/geno.1997.4868 }}
  • {{cite journal | vauthors=Rodriguez P, Pelletier J, Price GB, Zannis-Hadjopoulos M |title=NAP-2: histone chaperone function and phosphorylation state through the cell cycle. |journal=J. Mol. Biol. |volume=298 |issue= 2 |pages= 225–38 |year= 2000 |pmid= 10764593 |doi= 10.1006/jmbi.2000.3674 }}
  • {{cite journal |vauthors=Shikama N, Chan HM, Krstic-Demonacos M, etal |title=Functional interaction between nucleosome assembly proteins and p300/CREB-binding protein family coactivators. |journal=Mol. Cell. Biol. |volume=20 |issue= 23 |pages= 8933–43 |year= 2000 |pmid= 11073993 |doi=10.1128/MCB.20.23.8933-8943.2000 | pmc=86548 }}
  • {{cite journal |vauthors=Cicala C, Arthos J, Selig SM, etal |title=HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replication. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 14 |pages= 9380–5 |year= 2002 |pmid= 12089333 |doi= 10.1073/pnas.142287999 | pmc=123149 |bibcode=2002PNAS...99.9380C |doi-access=free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
  • {{cite journal | vauthors=Rodriguez P, Ruiz MT, Price GB, Zannis-Hadjopoulos M |title=NAP-2 is part of multi-protein complexes in HeLa cells. |journal=J. Cell. Biochem. |volume=93 |issue= 2 |pages= 398–408 |year= 2005 |pmid= 15368365 |doi= 10.1002/jcb.20163 |s2cid=12368640 }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Nousiainen M, Silljé HH, Sauer G, etal |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391–6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 | pmc=1459365 |bibcode=2006PNAS..103.5391N |doi-access=free }}
  • {{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |doi-access=free }}

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Category:Human proteins

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