NAV1
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Neuron navigator 1 is a protein that in humans is encoded by the NAV1 gene.{{cite journal | vauthors = Maes T, Barcelo A, Buesa C | title = Neuron navigator: a human gene family with homology to unc-53, a cell guidance gene from Caenorhabditis elegans | journal = Genomics | volume = 80 | issue = 1 | pages = 21–30 |date=Jun 2002 | pmid = 12079279 | doi =10.1006/geno.2002.6799 }}{{cite journal | vauthors = Coy JF, Wiemann S, Bechmann I, Bachner D, Nitsch R, Kretz O, Christiansen H, Poustka A | title = Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms | journal = Gene | volume = 290 | issue = 1–2 | pages = 73–94 |date=Jun 2002 | pmid = 12062803 | doi =10.1016/S0378-1119(02)00567-X }}{{cite web | title = Entrez Gene: NAV1 neuron navigator 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=89796}}
This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. The exact function of this gene is not known.
References
{{reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
- {{cite journal |vauthors=Peeters PJ, Baker A, Goris I, etal |title=Sensory deficits in mice hypomorphic for a mammalian homologue of unc-53 |journal=Brain Res. Dev. Brain Res. |volume=150 |issue= 2 |pages= 89–101 |year= 2004 |pmid= 15158073 |doi= 10.1016/j.devbrainres.2004.03.004 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
- {{cite journal |vauthors=Okazaki N, Kikuno R, Ohara R, etal |title=Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries |journal=DNA Res. |volume=10 |issue= 1 |pages= 35–48 |year= 2003 |pmid= 12693553 |doi=10.1093/dnares/10.1.35 |doi-access=free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | vauthors=Nakayama M, Kikuno R, Ohara O |title=Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773–84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902 | pmc=187542 }}
- {{cite journal |vauthors=Nagase T, Ishikawa K, Kikuno R, etal |title=Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=6 |issue= 5 |pages= 337–45 |year= 2000 |pmid= 10574462 |doi=10.1093/dnares/6.5.337 |doi-access=free }}
- {{cite journal |vauthors=Hirosawa M, Nagase T, Ishikawa K, etal |title=Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain |journal=DNA Res. |volume=6 |issue= 5 |pages= 329–36 |year= 2000 |pmid= 10574461 |doi=10.1093/dnares/6.5.329 |doi-access=free }}
{{refend}}
{{gene-1-stub}}