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NBR1

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Neighbor of BRCA1 gene 1 protein is a protein that in humans is encoded by the NBR1 gene.{{cite journal |vauthors=Campbell IG, Nicolai HM, Foulkes WD, Senger G, Stamp GW, Allan G, Boyer C, Jones K, ((Bast RC Jr)), Solomon E | title = A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1 | journal = Hum Mol Genet | volume = 3 | issue = 4 | pages = 589–594 |date=Sep 1994 | pmid = 8069304 | doi =10.1093/hmg/3.4.589 }}{{cite web | title = Entrez Gene: NBR1 neighbor of BRCA1 gene 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4077}}

The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene. One implied function lies in autophagy, where it acts a cargo receptor in selective autophagy.{{cite journal|last1=Kirkin|first1=Vladimir|title=A Role for Ubiquitin in Selective Autophagy|journal=Molecular Cell|date=2009|volume=34|issue=3|doi= 10.1016/j.molcel.2009.04.026|pmid=19450525|pages=259–269|doi-access=free}}

Interactions

NBR1 has been shown to interact with FEZ1.{{cite journal |last=Whitehouse |first=Caroline |author2=Chambers Julie |author3=Howe Kathy |author4=Cobourne Martyn |author5=Sharpe Paul |author6=Solomon Ellen |date=Jan 2002 |title=NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube |journal=Eur. J. Biochem. |volume=269 |issue=2 |pages=538–545 | issn = 0014-2956| pmid = 11856312 |doi=10.1046/j.0014-2956.2001.02681.x |doi-access=free }}

References

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Further reading

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  • {{cite journal | author=Miki Y |title=A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1 |journal=Science |volume=266 |issue= 5182 |pages= 66–71 |year= 1994 |pmid= 7545954 |doi=10.1126/science.7545954 |name-list-style=vanc| author2=Swensen J | author3=Shattuck-Eidens D | display-authors=3 | last4=Futreal | first4=P. | last5=Harshman | first5=K | last6=Tavtigian | first6=S | last7=Liu | first7=Q | last8=Cochran | first8=C | last9=Bennett | first9=L. |bibcode=1994Sci...266...66M| doi-access=free }}
  • {{cite journal | author=Harshman K |title=Comparison of the positional cloning methods used to isolate the BRCA1 gene |journal=Hum. Mol. Genet. |volume=4 |issue= 8 |pages= 1259–1266 |year= 1995 |pmid= 7581362 |doi=10.1093/hmg/4.8.1259 |name-list-style=vanc| author2=Bell R | author3=Rosenthal J | display-authors=3 | last4=Katcher | first4=Harold | last5=Mlkl | first5=Yoshio | last6=Swenson | first6=Jeff | last7=Gholami | first7=Zahra | last8=Frye | first8=Cheryl | last9=Ding | first9=Wei }}
  • {{cite journal | author=Nomura N |title=Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1 |journal=DNA Res. |volume=1 |issue= 5 |pages= 223–229 |year= 1995 |pmid= 7584044 |doi=10.1093/dnares/1.5.223 |name-list-style=vanc| author2=Nagase T | author3=Miyajima N | display-authors=3 | last4=Sazuka | first4=T | last5=Tanaka | first5=A | last6=Sato | first6=S | last7=Seki | first7=N | last8=Kawarabayasi | first8=Y | last9=Ishikawa | first9=K | doi-access=free }}
  • {{cite journal | author=Brown MA |title=Regulation of BRCA1 |journal=Nature |volume=372 |issue= 6508 |pages= 733 |year= 1995 |pmid= 7997258 |doi= 10.1038/372733a0 |name-list-style=vanc| author2=Nicolai H | author3=Xu CF | display-authors=3 | last4=Griffiths | first4=Beatrice L. | last5=Jones | first5=Karen A. | last6=Solomon | first6=Ellen | last7=Hosking | first7=Louise | last8=Trowsdale | first8=John | last9=Black | first9=Donald M. |bibcode=1994Natur.372..733B|s2cid=40825012 | doi-access=free }}
  • {{cite journal | author=Brown MA |title=The 5' end of the BRCA1 gene lies within a duplicated region of human chromosome 17q21 |journal=Oncogene |volume=12 |issue= 12 |pages= 2507–13 |year= 1996 |pmid= 8700509 |name-list-style=vanc| author2=Xu CF | author3=Nicolai H | display-authors=3 | last4=Griffiths | first4=B | last5=Chambers | first5=JA | last6=Black | first6=D | last7=Solomon | first7=E }}
  • {{cite journal |vauthors=Dimitrov S, Brennerova M, Forejt J |title=Expression profiles and intergenic structure of head-to-head oriented Brca1 and Nbr1 genes |journal=Gene |volume=262 |issue= 1–2 |pages= 89–98 |year= 2001 |pmid= 11179671 |doi=10.1016/S0378-1119(00)00549-7 }}
  • {{cite journal | author=Whitehouse C |title=NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube |journal=Eur. J. Biochem. |volume=269 |issue= 2 |pages= 538–545 |year= 2002 |pmid= 11856312 |doi=10.1046/j.0014-2956.2001.02681.x |name-list-style=vanc| author2=Chambers J | author3=Howe K | display-authors=3 | last4=Cobourne | first4=Martyn | last5=Sharpe | first5=Paul | last6=Solomon | first6=Ellen | doi-access=free }}
  • {{cite journal | author=Wistow G |title=Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium |journal=Mol. Vis. |volume=8 |pages= 185–95 |year= 2002 |pmid= 12107412 |name-list-style=vanc| author2=Bernstein SL | author3=Ray S | display-authors=3 | last4=Wyatt | first4=MK | last5=Behal | first5=A | last6=Touchman | first6=JW | last7=Bouffard | first7=G | last8=Smith | first8=D | last9=Peterson | first9=K }}
  • {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M|doi-access=free }}
  • {{cite journal | author=Lamark T |title=Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins |journal=J. Biol. Chem. |volume=278 |issue= 36 |pages= 34568–34581 |year= 2003 |pmid= 12813044 |doi= 10.1074/jbc.M303221200 |name-list-style=vanc| author2=Perander M | author3=Outzen H | display-authors=3 | last4=Kristiansen | first4=K | last5=Øvervatn | first5=A | last6=Michaelsen | first6=E | last7=Bjørkøy | first7=G | last8=Johansen | first8=T | doi-access=free }}
  • {{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–45 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-style=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki | doi-access=free }}
  • {{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
  • {{cite journal | author=Lange S |title=The kinase domain of titin controls muscle gene expression and protein turnover |journal=Science |volume=308 |issue= 5728 |pages= 1599–1603 |year= 2005 |pmid= 15802564 |doi= 10.1126/science.1110463 |name-list-style=vanc| author2=Xiang F | author3=Yakovenko A | display-authors=3 | last4=Vihola | first4=A | last5=Hackman | first5=P | last6=Rostkova | first6=E | last7=Kristensen | first7=J | last8=Brandmeier | first8=B | last9=Franzen | first9=G |bibcode=2005Sci...308.1599L|citeseerx=10.1.1.383.9888 |s2cid=2809403 }}
  • {{cite journal | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–1178 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |name-list-style=vanc| author2=Venkatesan K | author3=Hao T | display-authors=3 | last4=Hirozane-Kishikawa | first4=Tomoko | last5=Dricot | first5=Amélie | last6=Li | first6=Ning | last7=Berriz | first7=Gabriel F. | last8=Gibbons | first8=Francis D. | last9=Dreze | first9=Matija |bibcode=2005Natur.437.1173R|s2cid=4427026 }}

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{{PDB Gallery|geneid=4077}}

Category:Human proteins

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