NCAPG2
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Condensin-2 complex subunit G2 (CAP-G2) also known as chromosome-associated protein G2 (CAP-G2) or leucine zipper protein 5 (LUZP5) is a protein that in humans is encoded by the NCAPG2 gene.{{cite journal | vauthors = Ono T, Losada A, Hirano M, Myers MP, Neuwald AF, Hirano T | title = Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells | journal = Cell | volume = 115 | issue = 1 | pages = 109–21 | date = October 2003 | pmid = 14532007 | doi = 10.1016/S0092-8674(03)00724-4 | s2cid = 18811084 | doi-access = free }}{{cite web | title = Entrez Gene: NCAPG2 non-SMC condensin II complex, subunit G2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54892}} CAP-G2 is a subunit of condensin II, a large protein complex involved in chromosome condensation. It interacts with PLK1 through its C-terminal region during mitosis{{cite journal | vauthors = Kim JH, Shim J, Ji MJ, Jung Y, Bong SM, Jang YJ, Yoon EK, Lee SJ, Kim KG, Kim YH, Lee C, Lee BI, Kim KT | title = The condensin component NCAPG2 regulates microtubule-kinetochore attachment through recruitment of Polo-like kinase 1 to kinetochores | journal = Nature Communications | volume = 5 | pages = 4588 | date = August 2014 | pmid = 25109385 | doi = 10.1038/ncomms5588 | bibcode = 2014NatCo...5.4588K | doi-access = free }}
Clinical importance
Mutations in this gene in humans have been associated with severe neurodevelopmental defects, failure to thrive, ocular abnormalities, and defects in urogenital and limb morphogenesis.{{cite journal | vauthors = Khan TN, Khan K, Sadeghpour A, Reynolds H, Perilla Y, McDonald MT, Gallentine WB, Baig SM, Davis EE, Katsanis N | collaboration = Task Force for Neonatal Genomics | title = Mutations in NCAPG2 Cause a Severe Neurodevelopmental Syndrome that Expands the Phenotypic Spectrum of Condensinopathies | journal = American Journal of Human Genetics | volume = 104 | issue = 1 | pages = 94–111 | date = January 2019 | pmid = 30609410 | doi = 10.1016/j.ajhg.2018.11.017 | pmc = 6323578 }}
References
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Further reading
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- {{cite journal | vauthors = Smith ED, Xu Y, Tomson BN, Leung CG, Fujiwara Y, Orkin SH, Crispino JD | title = More than blood, a novel gene required for mammalian postimplantation development | journal = Molecular and Cellular Biology | volume = 24 | issue = 3 | pages = 1168–73 | date = February 2004 | pmid = 14729962 | pmc = 321451 | doi = 10.1128/MCB.24.3.1168-1173.2004 }}
- {{cite journal | vauthors = Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R | title = Phosphoproteome analysis of the human mitotic spindle | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 103 | issue = 14 | pages = 5391–6 | date = April 2006 | pmid = 16565220 | pmc = 1459365 | doi = 10.1073/pnas.0507066103 | bibcode = 2006PNAS..103.5391N | doi-access = free }}
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{{Nucleus}}
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