NEDD1
{{Short description|Protein-coding gene in the species Homo sapiens}}
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Neural precursor cell expressed, developmentally down-regulated 1, also known as Nedd1, is a human gene{{cite web | title = Entrez Gene: NEDD1 neural precursor cell expressed, developmentally down-regulated 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=121441| accessdate = }}
and encodes the protein NEDD1.
NEDD1 is localized in the centrosome and it plays a role in mitosis through its interaction with γ-tubulin. WD40 repeats are located in the amino-terminal of the protein and are responsible for NEDD1 localization in the centrosome, and the carboxy-terminal amino acids are needed for interactions with γ-tubulin. Depletion of NEDD1 causes impaired centrosome and chromatin microtubules assembly that results in the failure of microtubule nucleation and prevents proper spindle formation.
References
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Further reading
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- {{cite journal | vauthors=Pinyol R, Scrofani J, Vernos I |title=The role of NEDD1 phosphorylation by Aurora A in chromosomal microtubule nucleation and spindle function. |journal=Curr. Biol. |volume=23 |issue= 2 |pages= 143–9 |year= 2012 |pmid= 23273898 |doi= 10.1016/j.cub.2012.11.046|doi-access= free |hdl= 10230/23504 |hdl-access= free }}
- {{cite journal |vauthors=Sdelci S, Schütz M, Pinyol R, etal |title=Nek9 phosphorylation of NEDD1/GCP-WD contributes to Plk1 control of γ-tubulin recruitment to the mitotic centrosome. |journal=Curr. Biol. |volume=22 |issue= 16 |pages= 1516–23 |year= 2012 |pmid= 22818914 |doi= 10.1016/j.cub.2012.06.027 |doi-access= free |bibcode=2012CBio...22.1516S }}
- {{cite journal |vauthors=Haren L, Remy MH, Bazin I, etal |title=NEDD1-dependent recruitment of the gamma-tubulin ring complex to the centrosome is necessary for centriole duplication and spindle assembly. |journal=J. Cell Biol. |volume=172 |issue= 4 |pages= 505–15 |year= 2006 |pmid= 16461362 |doi= 10.1083/jcb.200510028 | pmc=2063671 }}
- {{cite journal | vauthors=Lüders J, Patel UK, Stearns T |title=GCP-WD is a gamma-tubulin targeting factor required for centrosomal and chromatin-mediated microtubule nucleation. |journal=Nat. Cell Biol. |volume=8 |issue= 2 |pages= 137–47 |year= 2006 |pmid= 16378099 |doi= 10.1038/ncb1349 |s2cid=27587898 }}
- {{cite journal |vauthors=Jung SY, Malovannaya A, Wei J, etal |title=Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes. |journal=Mol. Endocrinol. |volume=19 |issue= 10 |pages= 2451–65 |year= 2005 |pmid= 16051665 |doi= 10.1210/me.2004-0476 |doi-access= |s2cid=24948585 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Takai S, Yoshida Y, Noda M, etal |title=Assignment of the developmentally regulated gene NEDD1 to human chromosome 12q22 by fluorescence in situ hybridization. |journal=Hum. Genet. |volume=95 |issue= 1 |pages= 96–8 |year= 1995 |pmid= 7814034 |doi=10.1007/BF00225082 |s2cid=902030 }}
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