NETO1
{{Short description|Protein-coding gene in the species Homo sapiens}}
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Neuropilin (NRP) and tolloid (TLL)-like 1 is a protein that in humans is encoded by the NETO1 gene.{{cite web | title = Entrez Gene: Neuropilin (NRP) and tolloid (TLL)-like 1 | url = https://www.ncbi.nlm.nih.gov/gene/81832 }}
Function
This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in mice encodes a protein that plays a critical role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor complexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].
References
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Further reading
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- {{cite journal | vauthors = Ng D, Pitcher GM, Szilard RK, Sertié A, Kanisek M, Clapcote SJ, Lipina T, Kalia LV, Joo D, McKerlie C, Cortez M, Roder JC, Salter MW, McInnes RR | title = Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning | journal = PLOS Biology | volume = 7 | issue = 2 | pages = e41 | date = February 2009 | pmid = 19243221 | pmc = 2652390 | doi = 10.1371/journal.pbio.1000041 | doi-access = free }}
- {{cite journal | vauthors = Banno M, Koide T, Aleksic B, Yamada K, Kikuchi T, Kohmura K, Adachi Y, Kawano N, Kushima I, Ikeda M, Inada T, Yoshikawa T, Iwata N, Ozaki N | title = A case control association study and cognitive function analysis of neuropilin and tolloid-like 1 gene and schizophrenia in the Japanese population | journal = PLOS ONE | volume = 6 | issue = 12 | pages = e28929 | year = 2011 | pmid = 22205981 | pmc = 3243668 | doi = 10.1371/journal.pone.0028929 | bibcode = 2011PLoSO...628929B | doi-access = free }}
- {{cite journal | vauthors = Stöhr H, Berger C, Fröhlich S, Weber BH | title = A novel gene encoding a putative transmembrane protein with two extracellular CUB domains and a low-density lipoprotein class A module: isolation of alternatively spliced isoforms in retina and brain | journal = Gene | volume = 286 | issue = 2 | pages = 223–31 | date = March 2002 | pmid = 11943477 | doi = 10.1016/s0378-1119(02)00438-9 }}
- {{cite journal | vauthors = Benjamin DJ, Cesarini D, van der Loos MJ, Dawes CT, Koellinger PD, Magnusson PK, Chabris CF, Conley D, Laibson D, Johannesson M, Visscher PM | title = The genetic architecture of economic and political preferences | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 109 | issue = 21 | pages = 8026–31 | date = May 2012 | pmid = 22566634 | pmc = 3361436 | doi = 10.1073/pnas.1120666109 | bibcode = 2012PNAS..109.8026B | url = https://dash.harvard.edu/bitstream/handle/1/10121961/Benjamin_GeneticArchitecture.pdf?sequence=1 | doi-access = free }}
- {{cite journal | vauthors = O'Donnell L, Soileau B, Heard P, Carter E, Sebold C, Gelfond J, Hale DE, Cody JD | title = Genetic determinants of autism in individuals with deletions of 18q | journal = Human Genetics | volume = 128 | issue = 2 | pages = 155–64 | date = August 2010 | pmid = 20499253 | doi = 10.1007/s00439-010-0839-y | s2cid = 23659069 }}
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