NFAM1

{{Short description|Protein-coding gene in the species Homo sapiens}}

NFAT activating protein with ITAM motif 1 is a protein that in humans is encoded by the NFAM1 gene.

{{cite web

| title = Entrez Gene: NFAT activating protein with ITAM motif 1

| url = https://www.ncbi.nlm.nih.gov/gene/150372

| access-date = 2018-03-13

}}

Function

The protein encoded by this gene is a type I membrane receptor that activates cytokine gene promoters such as the IL-13 and TNF-alpha promoters. The encoded protein contains an Immunoreceptor tyrosine-based activation motif (ITAM) and is thought to regulate the signaling and development of B-cells. [provided by RefSeq, Jul 2008].

References

{{cite journal |vauthors=Yang J, Hu G, Wang SW, Li Y, Martin R, Li K, Yao Z |title=Calcineurin/nuclear factors of activated T cells (NFAT)-activating and immunoreceptor tyrosine-based activation motif (ITAM)-containing protein (CNAIP), a novel ITAM-containing protein that activates the calcineurin/NFAT-signaling pathway |journal=J. Biol. Chem. |volume=278 |issue=19 |pages=16797–801 |date=May 2003 |pmid=12615919 |doi=10.1074/jbc.M211060200 |doi-access=free }}
{{cite journal |vauthors=Nilsson LM, Sun ZW, Nilsson J, Nordström I, Chen YW, Molkentin JD, Wide-Swensson D, Hellstrand P, Lydrup ML, Gomez MF |title=Novel blocker of NFAT activation inhibits IL-6 production in human myometrial arteries and reduces vascular smooth muscle cell proliferation |journal=Am. J. Physiol., Cell Physiol. |volume=292 |issue=3 |pages=C1167–78 |date=March 2007 |pmid=17079331 |doi=10.1152/ajpcell.00590.2005 |url=http://portal.research.lu.se/ws/files/4923025/625765.pdf}}
{{cite journal |vauthors=Manley K, O'Hara BA, Atwood WJ |title=Nuclear factor of activated T-cells (NFAT) plays a role in SV40 infection |journal=Virology |volume=372 |issue=1 |pages=48–55 |date=March 2008 |pmid=18031784 |pmc=2289909 |doi=10.1016/j.virol.2007.10.029 }}

NFAM1

Function

References

Further reading