NFATC4

The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family of nuclear factors of activated T cells also participate in the formation of this complex. The product of this gene plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4.

NFATC4 has been shown to interact with CREB-binding protein.{{cite journal | vauthors = Yang T, Davis RJ, Chow CW | title = Requirement of two NFATc4 transactivation domains for CBP potentiation | journal = The Journal of Biological Chemistry | volume = 276 | issue = 43 | pages = 39569–76 | date = Oct 2001 | pmid = 11514544 | doi = 10.1074/jbc.M102961200 | doi-access =free }}

• NFAT

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• {{cite journal | vauthors = Rao A, Luo C, Hogan PG | title = Transcription factors of the NFAT family: regulation and function | journal = Annual Review of Immunology | volume = 15 | pages = 707–47 | year = 1997 | pmid = 9143705 | doi = 10.1146/annurev.immunol.15.1.707 }}
• {{cite journal | vauthors = Crabtree GR | title = Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT | journal = Cell | volume = 96 | issue = 5 | pages = 611–4 | date = Mar 1999 | pmid = 10089876 | doi = 10.1016/S0092-8674(00)80571-1 | s2cid = 8817053 | doi-access = free }}
• {{cite journal | vauthors = Horsley V, Pavlath GK | title = NFAT: ubiquitous regulator of cell differentiation and adaptation | journal = The Journal of Cell Biology | volume = 156 | issue = 5 | pages = 771–4 | date = Mar 2002 | pmid = 11877454 | pmc = 2173310 | doi = 10.1083/jcb.200111073 }}
• {{cite journal | vauthors = Jabado N, Le Deist F, Fisher A, Hivroz C | title = Interaction of HIV gp120 and anti-CD4 antibodies with the CD4 molecule on human CD4+ T cells inhibits the binding activity of NF-AT, NF-kappa B and AP-1, three nuclear factors regulating interleukin-2 gene enhancer activity | journal = European Journal of Immunology | volume = 24 | issue = 11 | pages = 2646–52 | date = Nov 1994 | pmid = 7957556 | doi = 10.1002/eji.1830241112 | s2cid = 30435577 }}
• {{cite journal | vauthors = Vacca A, Farina M, Maroder M, Alesse E, Screpanti I, Frati L, Gulino A | title = Human immunodeficiency virus type-1 tat enhances interleukin-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif | journal = Biochemical and Biophysical Research Communications | volume = 205 | issue = 1 | pages = 467–74 | date = Nov 1994 | pmid = 7999066 | doi = 10.1006/bbrc.1994.2689 }}
• {{cite journal | vauthors = Di Somma MM, Majolini MB, Burastero SE, Telford JL, Baldari CT | title = Cyclosporin A sensitivity of the HIV-1 long terminal repeat identifies distinct p56lck-dependent pathways activated by CD4 triggering | journal = European Journal of Immunology | volume = 26 | issue = 9 | pages = 2181–8 | date = Sep 1996 | pmid = 8814265 | doi = 10.1002/eji.1830260933 | s2cid = 23430217 }}
• {{cite journal | vauthors = Molkentin JD, Lu JR, Antos CL, Markham B, Richardson J, Robbins J, Grant SR, Olson EN | title = A calcineurin-dependent transcriptional pathway for cardiac hypertrophy | journal = Cell | volume = 93 | issue = 2 | pages = 215–28 | date = Apr 1998 | pmid = 9568714 | doi = 10.1016/S0092-8674(00)81573-1 | pmc = 4459646 }}
• {{cite journal | vauthors = Aramburu J, Garcia-Cózar F, Raghavan A, Okamura H, Rao A, Hogan PG | title = Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT | journal = Molecular Cell | volume = 1 | issue = 5 | pages = 627–37 | date = Apr 1998 | pmid = 9660947 | doi = 10.1016/S1097-2765(00)80063-5 | doi-access = free }}
• {{cite journal | vauthors = Chow CW, Davis RJ | title = Integration of calcium and cyclic AMP signaling pathways by 14-3-3 | journal = Molecular and Cellular Biology | volume = 20 | issue = 2 | pages = 702–12 | date = Jan 2000 | pmid = 10611249 | pmc = 85175 | doi = 10.1128/MCB.20.2.702-712.2000 }}
• {{cite journal | vauthors = Graef IA, Chen F, Chen L, Kuo A, Crabtree GR | title = Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature | journal = Cell | volume = 105 | issue = 7 | pages = 863–75 | date = Jun 2001 | pmid = 11439183 | doi = 10.1016/S0092-8674(01)00396-8 | s2cid = 5278706 | doi-access = free }}
• {{cite journal | vauthors = Yang T, Davis RJ, Chow CW | title = Requirement of two NFATc4 transactivation domains for CBP potentiation | journal = The Journal of Biological Chemistry | volume = 276 | issue = 43 | pages = 39569–76 | date = Oct 2001 | pmid = 11514544 | doi = 10.1074/jbc.M102961200 | doi-access =free }}
• {{cite journal | vauthors = Yang TT, Xiong Q, Enslen H, Davis RJ, Chow CW | title = Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases | journal = Molecular and Cellular Biology | volume = 22 | issue = 11 | pages = 3892–904 | date = Jun 2002 | pmid = 11997522 | pmc = 133816 | doi = 10.1128/MCB.22.11.3892-3904.2002 }}
• {{cite journal | vauthors = Bennasser Y, Badou A, Tkaczuk J, Bahraoui E | title = Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha | journal = Virology | volume = 303 | issue = 1 | pages = 174–80 | date = Nov 2002 | pmid = 12482669 | doi = 10.1006/viro.2002.1676 | doi-access = free }}
• {{cite journal | vauthors = Graef IA, Wang F, Charron F, Chen L, Neilson J, Tessier-Lavigne M, Crabtree GR | title = Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons | journal = Cell | volume = 113 | issue = 5 | pages = 657–70 | date = May 2003 | pmid = 12787506 | doi = 10.1016/S0092-8674(03)00390-8 | s2cid = 18024622 | doi-access = free }}
• {{cite journal | vauthors = Lahti AL, Manninen A, Saksela K | title = Regulation of T cell activation by HIV-1 accessory proteins: Vpr acts via distinct mechanisms to cooperate with Nef in NFAT-directed gene expression and to promote transactivation by CREB | journal = Virology | volume = 310 | issue = 1 | pages = 190–6 | date = May 2003 | pmid = 12788643 | doi = 10.1016/S0042-6822(03)00164-8 | doi-access = }}

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• {{MeshName|NFATC4+protein,+human}}

{{Transcription factors|g4}}

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Category:Transcription factors

Category:Human proteins

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