NFKBIB

NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]{{cite web | title = Entrez Gene: NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4793}}

NFKBIB has been shown to interact with:

• IKK2,{{cite journal | vauthors = Woronicz JD, Gao X, Cao Z, Rothe M, Goeddel DV | title = IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK | journal = Science | volume = 278 | issue = 5339 | pages = 866–9 | date = October 1997 | pmid = 9346485 | doi = 10.1126/science.278.5339.866| bibcode = 1997Sci...278..866W }}
• RELA,{{cite journal | vauthors = Chen Y, Wu J, Ghosh G | title = KappaB-Ras binds to the unique insert within the ankyrin repeat domain of IkappaBbeta and regulates cytoplasmic retention of IkappaBbeta x NF-kappaB complexes | journal = J. Biol. Chem. | volume = 278 | issue = 25 | pages = 23101–6 | date = June 2003 | pmid = 12672800 | doi = 10.1074/jbc.M301021200 | doi-access = free }}{{cite journal | vauthors = Suyang H, Phillips R, Douglas I, Ghosh S | title = Role of unphosphorylated, newly synthesized I kappa B beta in persistent activation of NF-kappa B | journal = Mol. Cell. Biol. | volume = 16 | issue = 10 | pages = 5444–9 | date = October 1996 | pmid = 8816457 | pmc = 231544 | doi = 10.1128/mcb.16.10.5444}} and
• Retinoid X receptor alpha.{{cite journal | vauthors = Na SY, Kim HJ, Lee SK, Choi HS, Na DS, Lee MO, Chung M, Moore DD, Lee JW | title = IkappaBbeta interacts with the retinoid X receptor and inhibits retinoid-dependent transactivation in lipopolysaccharide-treated cells | journal = J. Biol. Chem. | volume = 273 | issue = 6 | pages = 3212–5 | date = February 1998 | pmid = 9452433 | doi = 10.1074/jbc.273.6.3212| doi-access = free }}

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