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NFX1

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Transcriptional repressor NF-X1 is a protein that in humans is encoded by the NFX1 gene.{{cite journal | vauthors = Song Z, Krishna S, Thanos D, Strominger JL, Ono SJ | title = A novel cysteine-rich sequence-specific DNA-binding protein interacts with the conserved X-box motif of the human major histocompatibility complex class II genes via a repeated Cys-His domain and functions as a transcriptional repressor | journal = J Exp Med | volume = 180 | issue = 5 | pages = 1763–74 |date=Dec 1994 | pmid = 7964459 | pmc = 2191754 | doi =10.1084/jem.180.5.1763 }}{{cite journal | vauthors = Hume CR, Lee JS | title = Congenital immunodeficiencies associated with absence of HLA class II antigens on lymphocytes result from distinct mutations in trans-acting factors | journal = Hum Immunol | volume = 26 | issue = 4 | pages = 288–309 |date=Jan 1990 | pmid = 2511169 | doi =10.1016/0198-8859(89)90007-4 }}{{cite journal | vauthors = Arlotta P, Miyazaki D, Copeland NG, Gilbert DJ, Jenkins NA, Ono SJ | title = Murine NFX.1: isolation and characterization of its messenger RNA, mapping of its chromosomal location and assessment of its developmental expression | journal = Immunology | volume = 106 | issue = 2 | pages = 173–81 |date=June 2002 | pmid = 12047746 | pmc = 1782705 | doi = 10.1046/j.1365-2567.2002.01416.x }}

MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-γ. Three alternative splice variants, each of which encodes a different isoform, have been identified.{{cite web | title = Entrez Gene: NFX1 nuclear transcription factor, X-box binding 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4799}}

References

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Further reading

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  • {{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
  • {{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
  • {{cite journal |vauthors=Lorick KL, Jensen JP, Fang S, etal |title=RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 20 |pages= 11364–9 |year= 1999 |pmid= 10500182 |doi=10.1073/pnas.96.20.11364 | pmc=18039 |bibcode=1999PNAS...9611364L |doi-access=free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
  • {{cite journal |vauthors=Saito K, Fujiwara T, Katahira J, etal |title=TAP/NXF1, the primary mRNA export receptor, specifically interacts with a neuronal RNA-binding protein HuD |journal=Biochem. Biophys. Res. Commun. |volume=321 |issue= 2 |pages= 291–7 |year= 2004 |pmid= 15358174 |doi= 10.1016/j.bbrc.2004.06.140 }}
  • {{cite journal | vauthors=Gewin L, Myers H, Kiyono T, Galloway DA |title=Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complex |journal=Genes Dev. |volume=18 |issue= 18 |pages= 2269–82 |year= 2004 |pmid= 15371341 |doi= 10.1101/gad.1214704 | pmc=517520 }}
  • {{cite journal |vauthors=Katzenellenbogen RA, Egelkrout EM, Vliet-Gregg P, etal |title=NFX1-123 and poly(A) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 E6-expressing cells |journal=J. Virol. |volume=81 |issue= 8 |pages= 3786–96 |year= 2007 |pmid= 17267499 |doi= 10.1128/JVI.02007-06 | pmc=1866132 }}

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External links

  • {{MeshName|NFX1+protein,+human}}

{{Transcription factors|g1}}

Category:Transcription factors

{{Gene-9-stub}}