NFYB

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants.{{cite web | title = Entrez Gene: NFYB nuclear transcription factor Y, beta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4801}}

NFYB has been shown to interact with:

• CEBPZ,{{cite journal | vauthors = Imbriano C, Bolognese F, Gurtner A, Piaggio G, Mantovani R | title = HSP-CBF is an NF-Y-dependent coactivator of the heat shock promoters CCAAT boxes | journal = J. Biol. Chem. | volume = 276 | issue = 28 | pages = 26332–9 | date = Jul 2001 | pmid = 11306579 | doi = 10.1074/jbc.M101553200 | doi-access = free | hdl = 11380/303761 | hdl-access = free }}
• CNTN2,{{cite journal | vauthors = Pise-Masison CA, Dittmer J, Clemens KE, Brady JN | title = Physical and functional interaction between the human T-cell lymphotropic virus type 1 Tax1 protein and the CCAAT binding protein NF-Y | journal = Mol. Cell. Biol. | volume = 17 | issue = 3 | pages = 1236–43 | date = Mar 1997 | pmid = 9032250 | pmc = 231848 | doi = 10.1128/mcb.17.3.1236}}
• Myc,{{cite journal | vauthors = Izumi H, Molander C, Penn LZ, Ishisaki A, Kohno K, Funa K | title = Mechanism for the transcriptional repression by c-Myc on PDGF beta-receptor | journal = J. Cell Sci. | volume = 114 | issue = Pt 8 | pages = 1533–44 | date = Apr 2001 | doi = 10.1242/jcs.114.8.1533 | pmid = 11282029 }} and
• TBP{{cite journal | vauthors = Bellorini M, Lee DK, Dantonel JC, Zemzoumi K, Roeder RG, Tora L, Mantovani R | title = CCAAT binding NF-Y-TBP interactions: NF-YB and NF-YC require short domains adjacent to their histone fold motifs for association with TBP basic residues | journal = Nucleic Acids Res. | volume = 25 | issue = 11 | pages = 2174–81 | date = Jun 1997 | pmid = 9153318 | pmc = 146709 | doi = 10.1093/nar/25.11.2174}}

{{reflist}}

{{refbegin | 2}}

• {{cite journal | vauthors = Lloberas J, Soler C, Celada A | title = Repression mechanisms of the I-A beta gene of the major histocompatibility complex. | journal = Immunobiology | volume = 198 | issue = 1–3 | pages = 249–63 | year = 1998 | pmid = 9442396 | doi = 10.1016/s0171-2985(97)80045-9 }}
• {{cite journal | vauthors = Mantovani R | title = The molecular biology of the CCAAT-binding factor NF-Y | journal = Gene | volume = 239 | issue = 1 | pages = 15–27 | year = 1999 | pmid = 10571030 | doi = 10.1016/S0378-1119(99)00368-6 }}
• {{cite journal | vauthors = Li XY, Mantovani R, Hooft van Huijsduijnen R, Andre I, Benoist C, Mathis D | title = Evolutionary variation of the CCAAT-binding transcription factor NF-Y | journal = Nucleic Acids Res. | volume = 20 | issue = 5 | pages = 1087–91 | year = 1992 | pmid = 1549471 | pmc = 312095 | doi = 10.1093/nar/20.5.1087 }}
• {{cite journal | vauthors = Li XY, Hooft van Huijsduijnen R, Mantovani R, Benoist C, Mathis D | title = Intron-exon organization of the NF-Y genes. Tissue-specific splicing modifies an activation domain | journal = J. Biol. Chem. | volume = 267 | issue = 13 | pages = 8984–90 | year = 1992 | doi = 10.1016/S0021-9258(19)50377-5 | pmid = 1577736 | doi-access = free }}
• {{cite journal | vauthors = Lloberas J, Maki RA, Celada A | title = Repression of major histocompatibility complex I-A beta gene expression by dbpA and dbpB (mYB-1) proteins | journal = Mol. Cell. Biol. | volume = 15 | issue = 9 | pages = 5092–9 | year = 1995 | pmid = 7651426 | pmc = 230756 | doi = 10.1128/mcb.15.9.5092}}
• {{cite journal | vauthors = Chang ZF, Liu CJ | title = Human thymidine kinase CCAAT-binding protein is NF-Y, whose A subunit expression is serum-dependent in human IMR-90 diploid fibroblasts | journal = J. Biol. Chem. | volume = 269 | issue = 27 | pages = 17893–8 | year = 1994 | doi = 10.1016/S0021-9258(17)32393-1 | pmid = 8027044 | doi-access = free }}
• {{cite journal | vauthors = Mantovani R, Li XY, Pessara U, Hooft van Huisjduijnen R, Benoist C, Mathis D | title = Dominant negative analogs of NF-YA | journal = J. Biol. Chem. | volume = 269 | issue = 32 | pages = 20340–6 | year = 1994 | doi = 10.1016/S0021-9258(17)31997-X | pmid = 8051128 | doi-access = free }}
• {{cite journal | vauthors = Pise-Masison CA, Dittmer J, Clemens KE, Brady JN | title = Physical and functional interaction between the human T-cell lymphotropic virus type 1 Tax1 protein and the CCAAT binding protein NF-Y | journal = Mol. Cell. Biol. | volume = 17 | issue = 3 | pages = 1236–43 | year = 1997 | pmid = 9032250 | pmc = 231848 | doi = 10.1128/mcb.17.3.1236}}
• {{cite journal | vauthors = Bellorini M, Lee DK, Dantonel JC, Zemzoumi K, Roeder RG, Tora L, Mantovani R | title = CCAAT binding NF-Y-TBP interactions: NF-YB and NF-YC require short domains adjacent to their histone fold motifs for association with TBP basic residues | journal = Nucleic Acids Res. | volume = 25 | issue = 11 | pages = 2174–81 | year = 1997 | pmid = 9153318 | pmc = 146709 | doi = 10.1093/nar/25.11.2174 }}
• {{cite journal | vauthors = Currie RA | title = Functional interaction between the DNA binding subunit trimerization domain of NF-Y and the high mobility group protein HMG-I(Y) | journal = J. Biol. Chem. | volume = 272 | issue = 49 | pages = 30880–8 | year = 1998 | pmid = 9388234 | doi = 10.1074/jbc.272.49.30880 | doi-access = free }}
• {{cite journal | vauthors = Currie RA | title = NF-Y is associated with the histone acetyltransferases GCN5 and P/CAF | journal = J. Biol. Chem. | volume = 273 | issue = 3 | pages = 1430–4 | year = 1998 | pmid = 9430679 | doi = 10.1074/jbc.273.3.1430 | doi-access = free }}
• {{cite journal | vauthors = Currie RA | title = Biochemical characterization of the NF-Y transcription factor complex during B lymphocyte development | journal = J. Biol. Chem. | volume = 273 | issue = 29 | pages = 18220–9 | year = 1998 | pmid = 9660784 | doi = 10.1074/jbc.273.29.18220 | doi-access = free }}
• {{cite journal | vauthors = Bemark M, Olsson H, Heinegård D, Leanderson T | title = Purification and characterization of a protein binding to the SP6 kappa promoter. A potential role for CArG-box binding factor-A in kappa transcription | journal = J. Biol. Chem. | volume = 273 | issue = 30 | pages = 18881–90 | year = 1998 | pmid = 9668064 | doi = 10.1074/jbc.273.30.18881 |doi-access=free }}
• {{cite journal | vauthors = Faniello MC, Bevilacqua MA, Condorelli G, de Crombrugghe B, Maity SN, Avvedimento VE, Cimino F, Costanzo F | title = The B subunit of the CAAT-binding factor NFY binds the central segment of the Co-activator p300 | journal = J. Biol. Chem. | volume = 274 | issue = 12 | pages = 7623–6 | year = 1999 | pmid = 10075648 | doi = 10.1074/jbc.274.12.7623 |doi-access= free}}
• {{cite journal | vauthors = Hake SB, Masternak K, Kammerbauer C, Janzen C, Reith W, Steimle V | title = CIITA leucine-rich repeats control nuclear localization, in vivo recruitment to the major histocompatibility complex (MHC) class II enhanceosome, and MHC class II gene transactivation | journal = Mol. Cell. Biol. | volume = 20 | issue = 20 | pages = 7716–25 | year = 2000 | pmid = 11003667 | pmc = 86349 | doi = 10.1128/MCB.20.20.7716-7725.2000 }}
• {{cite journal | vauthors = Liang F, Schaufele F, Gardner DG | title = Functional interaction of NF-Y and Sp1 is required for type a natriuretic peptide receptor gene transcription | journal = J. Biol. Chem. | volume = 276 | issue = 2 | pages = 1516–22 | year = 2001 | pmid = 11022037 | doi = 10.1074/jbc.M006350200 | doi-access = free }}
• {{cite journal | vauthors = Izumi H, Molander C, Penn LZ, Ishisaki A, Kohno K, Funa K | title = Mechanism for the transcriptional repression by c-Myc on PDGF beta-receptor | journal = J. Cell Sci. | volume = 114 | issue = Pt 8 | pages = 1533–44 | year = 2001 | doi = 10.1242/jcs.114.8.1533 | pmid = 11282029 }}

{{refend}}

• {{MeshName|NFYB+protein,+human}}
• {{FactorBook|NF-YB}}

{{NLM content}}

{{PDB Gallery|geneid=4801}}

{{Transcription factors|g0}}

Category:Transcription factors

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