Login
Login

NKX2-3

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Homeobox protein Nkx-2.3 is a protein that in humans is encoded by the NKX2-3 gene.{{cite journal |vauthors=Price M, Lazzaro D, Pohl T, Mattei MG, Ruther U, Olivo JC, Duboule D, Di Lauro R | title = Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain | journal = Neuron | volume = 8 | issue = 2 | pages = 241–55 |date=Mar 1992 | pmid = 1346742 | doi =10.1016/0896-6273(92)90291-K | s2cid = 22766848 }}{{cite journal |vauthors=Pabst O, Schneider A, Brand T, Arnold HH | title = The mouse Nkx2-3 homeodomain gene is expressed in gut mesenchyme during pre- and postnatal mouse development | journal = Dev Dyn | volume = 209 | issue = 1 | pages = 29–35 |date=Jul 1997 | pmid = 9142493 | doi = 10.1002/(SICI)1097-0177(199705)209:1<29::AID-AJA3>3.0.CO;2-Z | doi-access = free }}{{cite web | title = Entrez Gene: NKX2-3 NK2 transcription factor related, locus 3 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=159296}}

NKX2C is a member of the NKX family of homeodomain-containing transcription factors, which are implicated in many aspects of cell type specification and maintenance of differentiated tissue functions.

References

{{reflist}}

Further reading

{{refbegin|35em}}

  • {{cite journal | author=Harvey RP |title=NK-2 homeobox genes and heart development. |journal=Dev. Biol. |volume=178 |issue= 2 |pages= 203–16 |year= 1996 |pmid= 8812123 |doi= 10.1006/dbio.1996.0212 |doi-access= free }}
  • {{cite journal |vauthors=Pabst O, Zweigerdt R, Arnold HH |title=Targeted disruption of the homeobox transcription factor Nkx2-3 in mice results in postnatal lethality and abnormal development of small intestine and spleen. |journal=Development |volume=126 |issue= 10 |pages= 2215–25 |year= 1999 |doi=10.1242/dev.126.10.2215 |pmid= 10207146 }}
  • {{cite journal | author=Phiel CJ |title=Differential binding of an SRF/NK-2/MEF2 transcription factor complex in normal versus neoplastic smooth muscle tissues |journal=J. Biol. Chem. |volume=276 |issue= 37 |pages= 34637–50 |year= 2001 |pmid= 11457859 |doi= 10.1074/jbc.M105826200 |name-list-style=vanc| author2=Gabbeta V | author3=Parsons LM | display-authors=3 | last4=Rothblat | first4=D | last5=Harvey | first5=RP | last6=McHugh | first6=KM | doi-access=free}}
  • {{cite journal |vauthors=Biben C, Wang CC, Harvey RP |title=NK-2 class homeobox genes and pharyngeal/oral patterning: Nkx2-3 is required for salivary gland and tooth morphogenesis |journal=Int. J. Dev. Biol. |volume=46 |issue= 4 |pages= 415–22 |year= 2003 |pmid= 12141427 }}
  • {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal | author=Deloukas P |title=The DNA sequence and comparative analysis of human chromosome 10 |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 |name-list-style=vanc| author2=Earthrowl ME | author3=Grafham DV | display-authors=3 | last4=Rubenfield | first4=M. | last5=French | first5=L. | last6=Steward | first6=C. A. | last7=Sims | first7=S. K. | last8=Jones | first8=M. C. | last9=Searle | first9=S. |bibcode=2004Natur.429..375D | doi-access=free }}
  • {{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}

{{refend}}

{{NLM content}}

{{Transcription factors|g3}}

Category:Transcription factors

{{gene-10-stub}}