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NLGN1

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Neuroligin-1 is a protein that in humans is encoded by the NLGN1 gene.{{cite journal |vauthors=Philibert RA, Winfield SL, Sandhu HK, Martin BM, Ginns EI |title=The structure and expression of the human neuroligin-3 gene |journal=Gene |volume=246 |issue=1–2 |pages=303–10 |date=April 2000 |pmid=10767552 |doi=10.1016/S0378-1119(00)00049-4}}{{cite journal |vauthors=Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O |title=Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Research |volume=7 |issue=2 |pages=143–50 |date=April 2000 |pmid=10819331 |doi=10.1093/dnares/7.2.143|doi-access=free }}{{cite web | title = Entrez Gene: NLGN1 neuroligin 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22871| accessdate = }}

This gene encodes a member of the neuroligin family of neuronal cell surface proteins. Neuroligin-1 acts as splice site-specific ligand for β-neurexins and has been shown to localize to the postsynaptic compartment at excitatory synapses and is involved in the formation and remodeling of central nervous system synapses.{{cite journal |vauthors=Scheiffele P, Fan J, Choih J, Fetter R, Serafini T |title=Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons |journal=Cell |volume=101 |issue=6 |pages=657–69 |date=June 2000 |pmid=10892652 |doi=10.1016/S0092-8674(00)80877-6|s2cid=16095623 |doi-access=free }}

Interactions

NLGN1 has been shown to interact with NRXN1{{cite journal |vauthors=Comoletti D, Flynn R, Jennings LL, etal |title=Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta |journal=The Journal of Biological Chemistry |volume=278 |issue=50 |pages=50497–505 |date=December 2003 |pmid=14522992 |doi=10.1074/jbc.M306803200|doi-access=free }}{{cite journal |vauthors=Ichtchenko K, Nguyen T, Südhof TC |title=Structures, alternative splicing, and neurexin binding of multiple neuroligins |journal=The Journal of Biological Chemistry |volume=271 |issue=5 |pages=2676–82 |date=February 1996 |pmid=8576240 |doi=10.1074/jbc.271.5.2676|doi-access=free }} and DLG4.{{cite journal |vauthors=Irie M, Hata Y, Takeuchi M, etal |title=Binding of neuroligins to PSD-95 |journal=Science |volume=277 |issue=5331 |pages=1511–5 |date=September 1997 |pmid=9278515 |doi=10.1126/science.277.5331.1511}}

See also

References

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Further reading

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  • {{cite journal |vauthors=Cantallops I, Cline HT |title=Synapse formation: if it looks like a duck and quacks like a duck .. |journal=Current Biology |volume=10 |issue=17 |pages=R620–3 |date=September 2000 |pmid=10996085 |doi=10.1016/S0960-9822(00)00663-1|s2cid=15851386 |doi-access=free }}
  • {{cite journal |vauthors=Ichtchenko K, Hata Y, Nguyen T, etal |title=Neuroligin 1: a splice site-specific ligand for beta-neurexins |journal=Cell |volume=81 |issue=3 |pages=435–43 |date=May 1995 |pmid=7736595 |doi=10.1016/0092-8674(95)90396-8|s2cid=15638953 |doi-access=free }}
  • {{cite journal |vauthors=Ichtchenko K, Nguyen T, Südhof TC |title=Structures, alternative splicing, and neurexin binding of multiple neuroligins |journal=The Journal of Biological Chemistry |volume=271 |issue=5 |pages=2676–82 |date=February 1996 |pmid=8576240 |doi=10.1074/jbc.271.5.2676|doi-access=free }}
  • {{cite journal |vauthors=Irie M, Hata Y, Takeuchi M, etal |title=Binding of neuroligins to PSD-95 |journal=Science |volume=277 |issue=5331 |pages=1511–5 |date=September 1997 |pmid=9278515 |doi=10.1126/science.277.5331.1511}}
  • {{cite journal |vauthors=Kikuno R, Nagase T, Ishikawa K, etal |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Research |volume=6 |issue=3 |pages=197–205 |date=June 1999 |pmid=10470851 |doi=10.1093/dnares/6.3.197|doi-access=free }}
  • {{cite journal |vauthors=Scheiffele P, Fan J, Choih J, Fetter R, Serafini T |title=Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons |journal=Cell |volume=101 |issue=6 |pages=657–69 |date=June 2000 |pmid=10892652 |doi=10.1016/S0092-8674(00)80877-6|s2cid=16095623 |doi-access=free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proceedings of the National Academy of Sciences of the United States of America |volume=99 |issue=26 |pages=16899–903 |date=December 2002 |pmid=12477932 |pmc=139241 |doi=10.1073/pnas.242603899|bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Comoletti D, Flynn R, Jennings LL, etal |title=Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta |journal=The Journal of Biological Chemistry |volume=278 |issue=50 |pages=50497–505 |date=December 2003 |pmid=14522992 |doi=10.1074/jbc.M306803200|doi-access=free }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nature Genetics |volume=36 |issue=1 |pages=40–5 |date=January 2004 |pmid=14702039 |doi=10.1038/ng1285|doi-access=free }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Research |volume=14 |issue=10B |pages=2121–7 |date=October 2004 |pmid=15489334 |pmc=528928 |doi=10.1101/gr.2596504}}
  • {{cite journal |vauthors=Chubykin AA, Liu X, Comoletti D, Tsigelny I, Taylor P, Südhof TC |title=Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism |journal=The Journal of Biological Chemistry |volume=280 |issue=23 |pages=22365–74 |date=June 2005 |pmid=15797875 |doi=10.1074/jbc.M410723200|doi-access=free }}
  • {{cite journal |vauthors=Muzny DM, Scherer SE, Kaul R, etal |title=The DNA sequence, annotation and analysis of human chromosome 3 |journal=Nature |volume=440 |issue=7088 |pages=1194–8 |date=April 2006 |pmid=16641997 |doi=10.1038/nature04728|bibcode=2006Natur.440.1194M |doi-access=free }}
  • {{cite journal |vauthors=Li X, Zhang J, Cao Z, Wu J, Shi Y |title=Solution structure of GOPC PDZ domain and its interaction with the C-terminal motif of neuroligin |journal=Protein Science |volume=15 |issue=9 |pages=2149–58 |date=September 2006 |pmid=16882988 |pmc=2242614 |doi=10.1110/ps.062087506}}

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