NLRC3

{{Short description|Protein-coding gene in the species Homo sapiens}}

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NLRC3, short for NOD-like receptor family CARD domain containing 3, is an intracellular protein that plays a role in the immune system.{{cite journal |vauthors=Ting JP, Lovering RC, Alnemri ES, etal |title=The NLR gene family: a standard nomenclature |journal=Immunity |volume=28 |issue=3 |pages=285–7 |date=March 2008 |pmid=18341998 |pmc=2630772 |doi=10.1016/j.immuni.2008.02.005 }} It was previously known as nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3 (NOD3) and CLR16.2. NLRC3 inhibits the activity of T cells.{{cite journal |vauthors=Conti BJ, Davis BK, Zhang J, O'connor W, Williams KL, Ting JP |title=CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function |journal=J. Biol. Chem. |volume=280 |issue=18 |pages=18375–85 |date=May 2005 |pmid=15705585 |doi=10.1074/jbc.M413169200 |doi-access=free }} NLRC3 also inhibits the mTOR signalling pathway to block cellular proliferation.{{Cite journal|last1=Karki|first1=Rajendra|last2=Man|first2=Si Ming|last3=Malireddi|first3=R. K. Subbarao|last4=Kesavardhana|first4=Sannula|last5=Zhu|first5=Qifan|last6=Burton|first6=Amanda R.|last7=Sharma|first7=Bhesh Raj|last8=Qi|first8=Xiaopeng|last9=Pelletier|first9=Stephane|last10=Vogel|first10=Peter|last11=Rosenstiel|first11=Philip|date=December 2016|title=NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer|journal=Nature|volume=540|issue=7634|pages=583–587|doi=10.1038/nature20597|pmid=27951586|pmc=5468516|bibcode=2016Natur.540..583K |issn=1476-4687}}