NLRP5
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
NLRP5, short for NOD-like receptor family pyrin domain containing 5, is an intracellular protein that plays a role in early embryogenesis.{{cite journal |author=Wu X |title=Maternal depletion of NLRP5 blocks early embryogenesis in rhesus macaque monkeys (Macaca mulatta) |journal=Hum. Reprod. |volume=24 |issue=2 |pages=415–24 |date=February 2009 |pmid=19054779 |doi=10.1093/humrep/den403 |doi-access=free }}{{cite journal |vauthors=Pisani LF, Ramelli P, Lazzari B, Braglia S, Ceciliani F, Mariani P |title=Characterization of maternal antigen that embryos require (MATER/NLRP5) gene and protein in pig somatic tissues and germ cells |journal=J. Reprod. Dev. |volume=56 |issue=1 |pages=41–8 |date=February 2010 |pmid=19815987 |doi= 10.1262/jrd.09-098a|doi-access=free }} NLRP5 is also known as NACHT, LRR and PYD domains-containing protein 5 (NALP5), Mater protein homolog (MATER), PYPAF8, PAN11, and CLR19.8, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors known to mammals.
In humans, the NLRP5 protein is encoded by the NLRP5 gene.{{cite web | title = Entrez Gene: NLR family| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=126206}}{{cite journal |vauthors=Tong ZB, Bondy CA, Zhou J, Nelson LM | title = A human homologue of mouse Mater, a maternal effect gene essential for early embryonic development | journal = Hum. Reprod. | volume = 17 | issue = 4 | pages = 903–11 |date=April 2002 | pmid = 11925379 | doi = 10.1093/humrep/17.4.903| doi-access = free }}{{cite journal |vauthors=Tschopp J, Martinon F, Burns K | title = NALPs: a novel protein family involved in inflammation | journal = Nat. Rev. Mol. Cell Biol. | volume = 4 | issue = 2 | pages = 95–104 |date=February 2003 | pmid = 12563287 | doi = 10.1038/nrm1019 | s2cid = 31417018 }}
References
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Further reading
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- {{cite journal |vauthors=Maraldi T, Riccio M, Sena P, etal |title=MATER protein as substrate of PKCepsilon in human cumulus cells. |journal=Mol. Hum. Reprod. |volume=15 |issue= 8 |pages= 499–506 |year= 2009 |pmid= 19542546 |doi= 10.1093/molehr/gap048 |doi-access= free }}
- {{cite journal |vauthors=Enjuanes A, Benavente Y, Bosch F, etal |title=Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. |journal=Cancer Res. |volume=68 |issue= 24 |pages= 10178–86 |year= 2008 |pmid= 19074885 |doi= 10.1158/0008-5472.CAN-08-2221 |doi-access= free }}
- {{cite journal |vauthors=Alimohammadi M, Björklund P, Hallgren A, etal |title=Autoimmune polyendocrine syndrome type 1 and NALP5, a parathyroid autoantigen. |journal=N. Engl. J. Med. |volume=358 |issue= 10 |pages= 1018–28 |year= 2008 |pmid= 18322283 |doi= 10.1056/NEJMoa0706487 |s2cid=6542627 |doi-access=free |hdl=11577/2265363 |hdl-access=free }}
- {{cite journal |vauthors=Sena P, Riccio M, Marzona L, etal |title=Human MATER localization in specific cell domains of oocytes and follicular cells. |journal=Reprod. Biomed. Online |volume=18 |issue= 2 |pages= 226–34 |year= 2009 |pmid= 19192343 |doi= 10.1016/s1472-6483(10)60260-x|doi-access=free }}
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{{NOD-like receptors}}
{{Transmembranereceptor-stub}}