NLRP7
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
NACHT, LRR and PYD domains-containing protein 7 is a protein that in humans is encoded by the NLRP7 gene.{{cite journal | vauthors = Tschopp J, Martinon F, Burns K | title = NALPs: a novel protein family involved in inflammation | journal = Nat Rev Mol Cell Biol | volume = 4 | issue = 2 | pages = 95–104 |date=Feb 2003 | pmid = 12563287 | doi = 10.1038/nrm1019 | s2cid = 31417018 }}{{cite journal | vauthors = Wang L, Manji GA, Grenier JM, Al-Garawi A, Merriam S, Lora JM, Geddes BJ, Briskin M, DiStefano PS, Bertin J | title = PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing | journal = J Biol Chem | volume = 277 | issue = 33 | pages = 29874–80 |date=Aug 2002 | pmid = 12019269 | doi = 10.1074/jbc.M203915200 | doi-access = free }}{{cite web | title = Entrez Gene: NLRP7 NLR family, pyrin domain containing 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=199713}}
Function
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP7, have an N-terminal pyrin (MEFV) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1) via their involvement in multiprotein complexes called inflammasomes.
References
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Further reading
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- {{cite journal | vauthors=Inohara N, Nuñez G |title=NODs: intracellular proteins involved in inflammation and apoptosis. |journal=Nat. Rev. Immunol. |volume=3 |issue= 5 |pages= 371–82 |year= 2003 |pmid= 12766759 |doi= 10.1038/nri1086 |s2cid=8088987 }}
- {{cite journal |vauthors=Moglabey YB, Kircheisen R, Seoud M, etal |title=Genetic mapping of a maternal locus responsible for familial hydatidiform moles. |journal=Hum. Mol. Genet. |volume=8 |issue= 4 |pages= 667–71 |year= 1999 |pmid= 10072436 |doi=10.1093/hmg/8.4.667 |doi-access=free }}
- {{cite journal |vauthors=Grenier JM, Wang L, Manji GA, etal |title=Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1. |journal=FEBS Lett. |volume=530 |issue= 1–3 |pages= 73–8 |year= 2002 |pmid= 12387869 |doi=10.1016/S0014-5793(02)03416-6 |s2cid=25023390 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Grimwood J, Gordon LA, Olsen A, etal |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 |bibcode=2004Natur.428..529G |doi-access= free }}
- {{cite journal |vauthors=Okada K, Hirota E, Mizutani Y, etal |title=Oncogenic role of NALP7 in testicular seminomas. |journal=Cancer Sci. |volume=95 |issue= 12 |pages= 949–54 |year= 2005 |pmid= 15596043 |doi=10.1111/j.1349-7006.2004.tb03182.x |s2cid=13403889 |doi-access=free |pmc=11158205 }}
- {{cite journal |vauthors=Kinoshita T, Wang Y, Hasegawa M, etal |title=PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion. |journal=J. Biol. Chem. |volume=280 |issue= 23 |pages= 21720–5 |year= 2005 |pmid= 15817483 |doi= 10.1074/jbc.M410057200 |doi-access= free |hdl= 2297/2649 |hdl-access= free }}
- {{cite journal |vauthors=Murdoch S, Djuric U, Mazhar B, etal |title=Mutations in NALP7 cause recurrent hydatidiform moles and reproductive wastage in humans. |journal=Nat. Genet. |volume=38 |issue= 3 |pages= 300–2 |year= 2006 |pmid= 16462743 |doi= 10.1038/ng1740 |s2cid=28580007 }}
- {{cite journal | vauthors=Bestor TH, Bourc'his D |title=Genetics and epigenetics of hydatidiform moles. |journal=Nat. Genet. |volume=38 |issue= 3 |pages= 274–6 |year= 2006 |pmid= 16501554 |doi= 10.1038/ng0306-274 |s2cid=22981053 }}
- {{cite journal |vauthors=Djuric U, El-Maarri O, Lamb B, etal |title=Familial molar tissues due to mutations in the inflammatory gene, NALP7, have normal postzygotic DNA methylation. |journal=Hum. Genet. |volume=120 |issue= 3 |pages= 390–5 |year= 2007 |pmid= 16874523 |doi= 10.1007/s00439-006-0192-3 |s2cid=10117000 |url=http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=132466 }}
- {{cite journal |vauthors=Qian J, Deveault C, Bagga R, etal |title=Women heterozygous for NALP7/NLRP7 mutations are at risk for reproductive wastage: report of two novel mutations. |journal=Hum. Mutat. |volume=28 |issue= 7 |pages= 741 |year= 2007 |pmid= 17579354 |doi= 10.1002/humu.9498 |s2cid=43136262 |doi-access=free }}
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{{NOD-like receptors}}
{{gene-19-stub}}