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NOVA1

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{cs1 config|name-list-style=vanc}}{{Infobox_gene}}

RNA-binding protein Nova-1 is a protein that in humans is encoded by the NOVA1 gene.{{cite journal | vauthors = Buckanovich RJ, Yang YY, Darnell RB | title = The onconeural antigen Nova-1 is a neuron-specific RNA-binding protein, the activity of which is inhibited by paraneoplastic antibodies | journal = J Neurosci | volume = 16 | issue = 3 | pages = 1114–22 |date=Feb 1996 | doi = 10.1523/JNEUROSCI.16-03-01114.1996 | pmid = 8558240 | pmc = 6578795 }}{{cite web | title = Entrez Gene: NOVA1 neuro-oncological ventral antigen 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4857}}

This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described. Both Neanderthals and Denisovans had one version and nearly all modern humans had another suggesting positive selection. Insertion of Neanderthal gene variant of the neuro-oncological ventral antigen 1 (NOVA1) gene into human cortical organoids might promote slower development and higher surface complexity in the brain models,{{Cite web|url=https://www.genomeweb.com/gene-silencinggene-editing/neanderthal-gene-variant-alters-neurodevelopment-human-brain-organoids|title = Neanderthal Gene Variant Alters Neurodevelopment in Human Brain Organoids|date = 11 February 2021}} but this may be an artefact of a CRISPR side effect,{{Cite journal |last1=Maricic |first1=Tomislav |last2=Helmbrecht |first2=Nelly |last3=Riesenberg |first3=Stephan |last4=Macak |first4=Dominik |last5=Kanis |first5=Philipp |last6=Lackner |first6=Martin |last7=Pugach-Matveeva |first7=Agrafena Daria |last8=Pääbo |first8=Svante |date=2021-10-15 |title=Comment on "Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment" |url=https://www.science.org/doi/10.1126/science.abi6060 |journal=Science |language=en |volume=374 |issue=6565 |pages=eabi6060 |doi=10.1126/science.abi6060 |pmid=34648345 |s2cid=238990790 |issn=0036-8075}}{{Cite journal |last1=Herai |first1=Roberto H. |last2=Szeto |first2=Ryan A. |last3=Trujillo |first3=Cleber A. |last4=Muotri |first4=Alysson R. |date=2021-10-15 |title=Response to Comment on "Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment" |url=https://www.science.org/doi/10.1126/science.abi9881 |journal=Science |language=en |volume=374 |issue=6565 |pages=eabi9881 |doi=10.1126/science.abi9881 |pmid=34648331 |s2cid=238990560 |issn=0036-8075}} as it could not be replicated in a subsequent study.{{Cite journal |last1=Riesenberg |first1=Stephan |last2=Kanis |first2=Philipp |last3=Macak |first3=Dominik |last4=Wollny |first4=Damian |last5=Düsterhöft |first5=Dorothee |last6=Kowalewski |first6=Johannes |last7=Helmbrecht |first7=Nelly |last8=Maricic |first8=Tomislav |last9=Pääbo |first9=Svante |date=2023-07-20 |title=Efficient high-precision homology-directed repair-dependent genome editing by HDRobust |journal=Nature Methods |volume=20 |issue=9 |pages=1388–1399 |language=en |doi=10.1038/s41592-023-01949-1 |issn=1548-7091|doi-access=free |pmid=37474806 |pmc=10482697 }}

References

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Further reading

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  • {{cite journal | vauthors=Buckanovich RJ, Posner JB, Darnell RB |title=Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system |journal=Neuron |volume=11 |issue= 4 |pages= 657–72 |year= 1993 |pmid= 8398153 |doi=10.1016/0896-6273(93)90077-5 |s2cid=22554933 }}
  • {{cite journal | vauthors=Buckanovich RJ, Darnell RB |title=The neuronal RNA binding protein Nova-1 recognizes specific RNA targets in vitro and in vivo |journal=Mol. Cell. Biol. |volume=17 |issue= 6 |pages= 3194–201 |year= 1997 |doi=10.1128/MCB.17.6.3194 |pmid= 9154818 | pmc=232172 }}
  • {{cite journal |vauthors=Lewis HA, Chen H, Edo C, etal |title=Crystal structures of Nova-1 and Nova-2 K-homology RNA-binding domains |journal=Structure |volume=7 |issue= 2 |pages= 191–203 |year= 1999 |pmid= 10368286 |doi=10.1016/S0969-2126(99)80025-2 |doi-access=free }}
  • {{cite journal |vauthors=Jensen KB, Dredge BK, Stefani G, etal |title=Nova-1 regulates neuron-specific alternative splicing and is essential for neuronal viability |journal=Neuron |volume=25 |issue= 2 |pages= 359–71 |year= 2000 |pmid= 10719891 |doi=10.1016/S0896-6273(00)80900-9 |doi-access=free }}
  • {{cite journal |vauthors=Dias Neto E, Correa RG, Verjovski-Almeida S, etal |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=10.1073/pnas.97.7.3491 | pmc=16267 |bibcode=2000PNAS...97.3491D |doi-access=free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal | vauthors=Dredge BK, Darnell RB |title=Nova regulates GABA(A) receptor gamma2 alternative splicing via a distal downstream UCAU-rich intronic splicing enhancer |journal=Mol. Cell. Biol. |volume=23 |issue= 13 |pages= 4687–700 |year= 2003 |pmid= 12808107 |doi=10.1128/MCB.23.13.4687-4700.2003 | pmc=164843 }}
  • {{cite journal |vauthors=Brandenberger R, Wei H, Zhang S, etal |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 |s2cid=27764390 }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Ule J, Ule A, Spencer J, etal |title=Nova regulates brain-specific splicing to shape the synapse |journal=Nat. Genet. |volume=37 |issue= 8 |pages= 844–52 |year= 2005 |pmid= 16041372 |doi= 10.1038/ng1610 |s2cid=8446567 }}
  • {{cite journal |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |doi-access= free }}

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