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NOX5

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

NADPH oxidase, EF-hand calcium binding domain 5, also known as NOX5, is a protein which in humans is encoded by the NOX5 gene.{{cite web | title = Entrez Gene: NOX5 NADPH oxidase, EF-hand calcium binding domain 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79400}}{{cite journal | vauthors = Bánfi B, Molnár G, Maturana A, Steger K, Hegedûs B, Demaurex N, Krause KH | title = A Ca(2+)-activated NADPH oxidase in testis, spleen, and lymph nodes | journal = J. Biol. Chem. | volume = 276 | issue = 40 | pages = 37594–601 |date=October 2001 | pmid = 11483596 | doi = 10.1074/jbc.M103034200 | doi-access = free }}

Function

NOX5 is a novel NADPH oxidase that generates superoxide.

Nox5 interacts with c-abl, superoxide production leads to phosphorylation of c-abl, while inhibition of c-abl kinase activity inhibits Nox5 superoxide production.{{cite journal | vauthors = El Jamali A, Valente AJ, Lechleiter JD, Gamez MJ, Pearson DW, Nauseef WM, Clark RA | title = Novel redox-dependent regulation of NOX5 by the tyrosine kinase c-Abl | journal = Free Radic. Biol. Med. | volume = 44 | issue = 5 | pages = 868–81 |date=March 2008 | pmid = 18160052 | pmc = 2278123 | doi = 10.1016/j.freeradbiomed.2007.11.020 }}

References

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Further reading

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  • {{cite journal |vauthors=Lachgar A, Sojic N, Arbault S, etal |title=Amplification of the Inflammatory Cellular Redox State by Human Immunodeficiency Virus Type 1-Immunosuppressive Tat and gp160 Proteins |journal=J. Virol. |volume=73 |issue= 2 |pages= 1447–52 |year= 1999 |doi=10.1128/JVI.73.2.1447-1452.1999 |pmid= 9882350 | pmc=103969 }}
  • {{cite journal |vauthors=Cheng G, Cao Z, Xu X, etal |title=Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5 |journal=Gene |volume=269 |issue= 1–2 |pages= 131–40 |year= 2001 |pmid= 11376945 |doi=10.1016/S0378-1119(01)00449-8 }}
  • {{cite journal |vauthors=Bánfi B, Molnár G, Maturana A, etal |title=A Ca(2+)-activated NADPH oxidase in testis, spleen, and lymph nodes |journal=J. Biol. Chem. |volume=276 |issue= 40 |pages= 37594–601 |year= 2001 |pmid= 11483596 |doi= 10.1074/jbc.M103034200 |doi-access= free }}
  • {{cite journal |vauthors=Armstrong JS, Bivalacqua TJ, Chamulitrat W, etal |title=A comparison of the NADPH oxidase in human sperm and white blood cells |journal=Int. J. Androl. |volume=25 |issue= 4 |pages= 223–9 |year= 2002 |pmid= 12121572 |doi=10.1046/j.1365-2605.2002.00351.x |doi-access=free }}
  • {{cite journal |vauthors=Moskwa P, Dagher MC, Paclet MH, etal |title=Participation of Rac GTPase activating proteins in the deactivation of the phagocytic NADPH oxidase |journal=Biochemistry |volume=41 |issue= 34 |pages= 10710–6 |year= 2002 |pmid= 12186557 |doi=10.1021/bi0257033 }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
  • {{cite journal |vauthors=Bánfi B, Tirone F, Durussel I, etal |title=Mechanism of Ca2+ activation of the NADPH oxidase 5 (NOX5) |journal=J. Biol. Chem. |volume=279 |issue= 18 |pages= 18583–91 |year= 2004 |pmid= 14982937 |doi= 10.1074/jbc.M310268200 |doi-access= free }}
  • {{cite journal | vauthors=Jana A, Pahan K |title=Human Immunodeficiency Virus Type 1 gp120 Induces Apoptosis in Human Primary Neurons through Redox-Regulated Activation of Neutral Sphingomyelinase |journal=J. Neurosci. |volume=24 |issue= 43 |pages= 9531–40 |year= 2005 |pmid= 15509740 |doi= 10.1523/JNEUROSCI.3085-04.2004 | pmc=1955476 }}
  • {{cite journal | vauthors=Kawahara T, Ritsick D, Cheng G, Lambeth JD |title=Point mutations in the proline-rich region of p22phox are dominant inhibitors of Nox1- and Nox2-dependent reactive oxygen generation |journal=J. Biol. Chem. |volume=280 |issue= 36 |pages= 31859–69 |year= 2005 |pmid= 15994299 |doi= 10.1074/jbc.M501882200 |doi-access= free }}
  • {{cite journal | vauthors=Femling JK, Nauseef WM, Weiss JP |title=Synergy between extracellular group IIA phospholipase A2 and phagocyte NADPH oxidase in digestion of phospholipids of Staphylococcus aureus ingested by human neutrophils |journal=J. Immunol. |volume=175 |issue= 7 |pages= 4653–61 |year= 2005 |pmid= 16177112 |doi= 10.4049/jimmunol.175.7.4653|doi-access=free }}
  • {{cite journal |vauthors=Cucoranu I, Clempus R, Dikalova A, etal |title=NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts |journal=Circ. Res. |volume=97 |issue= 9 |pages= 900–7 |year= 2005 |pmid= 16179589 |doi= 10.1161/01.RES.0000187457.24338.3D |doi-access= free }}
  • {{cite journal |vauthors=Kamiguti AS, Serrander L, Lin K, etal |title=Expression and activity of NOX5 in the circulating malignant B cells of hairy cell leukemia |journal=J. Immunol. |volume=175 |issue= 12 |pages= 8424–30 |year= 2006 |pmid= 16339585 |doi= 10.4049/jimmunol.175.12.8424|doi-access=free }}
  • {{cite journal |vauthors=Fu X, Beer DG, Behar J, etal |title=cAMP-response element-binding protein mediates acid-induced NADPH oxidase NOX5-S expression in Barrett esophageal adenocarcinoma cells |journal=J. Biol. Chem. |volume=281 |issue= 29 |pages= 20368–82 |year= 2006 |pmid= 16707484 |doi= 10.1074/jbc.M603353200 |doi-access= free }}
  • {{cite journal |vauthors=Duerrschmidt N, Stielow C, Muller G, etal |title=NO-mediated regulation of NAD(P)H oxidase by laminar shear stress in human endothelial cells |journal=J. Physiol. |volume=576 |issue= Pt 2 |pages= 557–67 |year= 2006 |pmid= 16873416 |doi= 10.1113/jphysiol.2006.111070 | pmc=1890367 }}
  • {{cite journal |vauthors=Chenevier-Gobeaux C, Lemarechal H, Bonnefont-Rousselot D, etal |title=Superoxide production and NADPH oxidase expression in human rheumatoid synovial cells: regulation by interleukin-1beta and tumour necrosis factor-alpha |journal=Inflamm. Res. |volume=55 |issue= 11 |pages= 483–90 |year= 2007 |pmid= 17122966 |doi= 10.1007/s00011-006-6036-8 |s2cid=9576123 }}
  • {{cite journal |vauthors=Jagnandan D, Church JE, Banfi B, etal |title=Novel mechanism of activation of NADPH oxidase 5. calcium sensitization via phosphorylation |journal=J. Biol. Chem. |volume=282 |issue= 9 |pages= 6494–507 |year= 2007 |pmid= 17164239 |doi= 10.1074/jbc.M608966200 |doi-access= free }}
  • {{cite journal |vauthors=BelAiba RS, Djordjevic T, Petry A, etal |title=NOX5 variants are functionally active in endothelial cells |journal=Free Radic. Biol. Med. |volume=42 |issue= 4 |pages= 446–59 |year= 2007 |pmid= 17275676 |doi= 10.1016/j.freeradbiomed.2006.10.054 }}
  • {{cite journal | vauthors=Tirone F, Cox JA |title=NADPH oxidase 5 (NOX5) interacts with and is regulated by calmodulin |journal=FEBS Lett. |volume=581 |issue= 6 |pages= 1202–8 |year= 2007 |pmid= 17346712 |doi= 10.1016/j.febslet.2007.02.047 |doi-access= free }}
  • {{cite journal | vauthors=Qin F, Simeone M, Patel R |title=Inhibition of NADPH oxidase reduces myocardial oxidative stress and apoptosis and improves cardiac function in heart failure after myocardial infarction |journal=Free Radic. Biol. Med. |volume=43 |issue= 2 |pages= 271–81 |year= 2007 |pmid= 17603936 |doi= 10.1016/j.freeradbiomed.2007.04.021 }}

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Category:EF-hand-containing proteins

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