NPR1

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{for|the gene in A. thaliana|Arabidopsis thaliana#NPR1}}{{Confused|NPR One}}{{Infobox_gene}}

Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A), also known as NPR1, is an atrial natriuretic peptide receptor. In humans it is encoded by the NPR1 gene.

Function

NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP and BNP, respectively).{{cite web | title = Entrez Gene: NPR1 natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4881}}

It is localized in the kidney[http://biogps.gnf.org/#goto=genereport&id=4881 BioGPS > NPR1] Retrieved Nov 2010 {{webarchive |url=https://web.archive.org/web/20101127041532/http://biogps.gnf.org/#goto=genereport&id=4881 |date=November 27, 2010 }} where it results in natriuresis upon binding to natriuretic peptides. However, it is found in even greater quantity in the lungs and adipocytes.

See also

Atrial natriuretic peptide receptor

References

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Further reading

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{{cite journal | author=Pandey KN |title=Intracellular trafficking and metabolic turnover of ligand-bound guanylyl cyclase/atrial natriuretic peptide receptor-A into subcellular compartments. |journal=Mol. Cell. Biochem. |volume=230 |issue= 1–2 |pages= 61–72 |year= 2002 |pmid= 11952097 |doi=10.1023/A:1014240006767 |s2cid=10397726 }}
{{cite journal |vauthors=Lucarelli K, Iacoviello M, Dessì-Fulgheri P, etal |title=[Natriuretic peptides and essential arterial hypertension] |journal=Italian Heart Journal Supplement |volume=3 |issue= 11 |pages= 1085–91 |year= 2003 |pmid= 12506509 }}
{{cite journal | author=Pandey KN |title=Internalization and trafficking of guanylyl cyclase/natriuretic peptide receptor-A |journal=Peptides |volume=26 |issue= 6 |pages= 985–1000 |year= 2005 |pmid= 15911067 |doi= 10.1016/j.peptides.2004.12.020 |s2cid=34452043 }}
{{cite journal |vauthors=Garg R, Pandey KN |title=Regulation of guanylyl cyclase/natriuretic peptide receptor-A gene expression |journal=Peptides |volume=26 |issue= 6 |pages= 1009–23 |year= 2005 |pmid= 15911069 |doi= 10.1016/j.peptides.2004.09.022 |s2cid=33508201 }}

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External links

{{MeshName|NPR1+protein,+human}}

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{{Neuropeptide receptors}}

{{Enzyme-linked receptors}}

{{Phosphorus-oxygen lyases}}

{{Enzymes}}

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Category:EC 4.6.1

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