NPR2

{{Short description|Human protein-coding gene}}

{{Infobox gene}}

Natriuretic peptide receptor B (NPR2), also known as atrionatriuretic peptide receptor B and formerly as guanylate cyclase B, is an atrial natriuretic peptide receptor which in humans is encoded by the NPR2 gene.{{cite web | title = Entrez Gene: NPR2 natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4882}}

A mutation in the NPR2 gene can result in achondroplasia and disproportionate dwarfism with short limbs.{{cite journal | vauthors = Tsuji T, Kunieda T | title = A loss-of-function mutation in natriuretic peptide receptor 2 (Npr2) gene is responsible for disproportionate dwarfism in cn/cn mouse | journal = The Journal of Biological Chemistry | volume = 280 | issue = 14 | pages = 14288–92 | date = April 2005 | pmid = 15722353 | doi = 10.1074/jbc.C500024200 | doi-access = free }}

See also

References

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Further reading

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  • {{cite journal | vauthors = Fox AA, Collard CD, Shernan SK, Seidman CE, Seidman JG, Liu KY, Muehlschlegel JD, Perry TE, Aranki SF, Lange C, Herman DS, Meitinger T, Lichtner P, Body SC | display-authors = 6 | title = Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting | journal = Anesthesiology | volume = 110 | issue = 4 | pages = 738–47 | date = April 2009 | pmid = 19326473 | pmc = 2735337 | doi = 10.1097/ALN.0b013e31819c7496 }}
  • {{cite journal | vauthors = Potthast R, Abbey-Hosch SE, Antos LK, Marchant JS, Kuhn M, Potter LR | title = Calcium-dependent dephosphorylation mediates the hyperosmotic and lysophosphatidic acid-dependent inhibition of natriuretic peptide receptor-B/guanylyl cyclase-B | journal = The Journal of Biological Chemistry | volume = 279 | issue = 47 | pages = 48513–9 | date = November 2004 | pmid = 15371450 | doi = 10.1074/jbc.M408247200 | doi-access = free }}
  • {{cite journal | vauthors = Liew D, Schneider H, D'Agostino J, Shaw J, Krum H | title = Utility of B-type natriuretic peptide as a screen for left ventricular dysfunction in patients with diabetes: response to Epshteyn et al | journal = Diabetes Care | volume = 27 | issue = 3 | pages = 848; author reply 848-9 | date = March 2004 | pmid = 14988324 | doi = 10.2337/diacare.27.3.848 | doi-access = free }}
  • {{cite journal | vauthors = Antos LK, Abbey-Hosch SE, Flora DR, Potter LR | title = ATP-independent activation of natriuretic peptide receptors | journal = The Journal of Biological Chemistry | volume = 280 | issue = 29 | pages = 26928–32 | date = July 2005 | pmid = 15911610 | doi = 10.1074/jbc.M505648200 | doi-access = free }}
  • {{cite journal | vauthors = Poreba R, Poczatek K, Gać P, Poreba M, Gonerska M, Jonkisz A, Derkacz A, Negrusz-Kawecka M, Sobieszczańska M, Pilecki W, Szuba A, Andrzejak R | display-authors = 6 | title = SNP rs198389 (T-381 C) polymorphism in the B-type natriuretic peptide gene promoter in patients with atherosclerotic renovascular hypertension | journal = Polskie Archiwum Medycyny Wewnetrznej | volume = 119 | issue = 4 | pages = 219–24 | date = April 2009 | pmid = 19413180 }}
  • {{cite journal | vauthors = Koller KJ, Goeddel DV | title = Molecular biology of the natriuretic peptides and their receptors | journal = Circulation | volume = 86 | issue = 4 | pages = 1081–8 | date = October 1992 | pmid = 1327579 | doi = 10.1161/01.cir.86.4.1081 | doi-access = free }}
  • {{cite journal | vauthors = Fan D, Bryan PM, Antos LK, Potthast RJ, Potter LR | title = Down-regulation does not mediate natriuretic peptide-dependent desensitization of natriuretic peptide receptor (NPR)-A or NPR-B: guanylyl cyclase-linked natriuretic peptide receptors do not internalize | journal = Molecular Pharmacology | volume = 67 | issue = 1 | pages = 174–83 | date = January 2005 | pmid = 15459247 | doi = 10.1124/mol.104.002436 | s2cid = 53520 }}
  • {{cite journal | vauthors = Pagel-Langenickel I, Buttgereit J, Bader M, Langenickel TH | title = Natriuretic peptide receptor B signaling in the cardiovascular system: protection from cardiac hypertrophy | journal = Journal of Molecular Medicine | volume = 85 | issue = 8 | pages = 797–810 | date = August 2007 | pmid = 17429599 | doi = 10.1007/s00109-007-0183-4 | s2cid = 42834676 | url = https://zenodo.org/record/1232599 }}
  • {{cite journal | vauthors = Rahmutula D, Cui J, Chen S, Gardner DG | title = Transcriptional regulation of type B human natriuretic Peptide receptor gene promoter: dependence on Sp1 | journal = Hypertension | volume = 44 | issue = 3 | pages = 283–8 | date = September 2004 | pmid = 15262909 | doi = 10.1161/01.HYP.0000136908.60317.92 | doi-access = free }}
  • {{cite journal | vauthors = Hume AN, Buttgereit J, Al-Awadhi AM, Al-Suwaidi SS, John A, Bader M, Seabra MC, Al-Gazali L, Ali BR | display-authors = 6 | title = Defective cellular trafficking of missense NPR-B mutants is the major mechanism underlying acromesomelic dysplasia-type Maroteaux | journal = Human Molecular Genetics | volume = 18 | issue = 2 | pages = 267–77 | date = January 2009 | pmid = 18945719 | pmc = 2638773 | doi = 10.1093/hmg/ddn354 }}
  • {{cite journal | vauthors = Schulz S | title = C-type natriuretic peptide and guanylyl cyclase B receptor | journal = Peptides | volume = 26 | issue = 6 | pages = 1024–34 | date = June 2005 | pmid = 15911070 | doi = 10.1016/j.peptides.2004.08.027 | s2cid = 24299700 }}
  • {{cite journal | vauthors = Dickey DM, Yoder AR, Potter LR | title = A familial mutation renders atrial natriuretic Peptide resistant to proteolytic degradation | journal = The Journal of Biological Chemistry | volume = 284 | issue = 29 | pages = 19196–202 | date = July 2009 | pmid = 19458086 | pmc = 2740543 | doi = 10.1074/jbc.M109.010777 | doi-access = free }}
  • {{cite journal | vauthors = Nozohoor S, Nilsson J, Lührs C, Roijer A, Algotsson L, Sjögren J | title = B-type natriuretic peptide as a predictor of postoperative heart failure after aortic valve replacement | journal = Journal of Cardiothoracic and Vascular Anesthesia | volume = 23 | issue = 2 | pages = 161–5 | date = April 2009 | pmid = 19167912 | doi = 10.1053/j.jvca.2008.11.006 }}
  • {{cite journal | vauthors = Hachiya R, Ohashi Y, Kamei Y, Suganami T, Mochizuki H, Mitsui N, Saitoh M, Sakuragi M, Nishimura G, Ohashi H, Hasegawa T, Ogawa Y | display-authors = 6 | title = Intact kinase homology domain of natriuretic peptide receptor-B is essential for skeletal development | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 92 | issue = 10 | pages = 4009–14 | date = October 2007 | pmid = 17652215 | doi = 10.1210/jc.2007-1101 | doi-access = free }}
  • {{cite journal | vauthors = Gratacòs M, Costas J, de Cid R, Bayés M, González JR, Baca-García E, de Diego Y, Fernández-Aranda F, Fernández-Piqueras J, Guitart M, Martín-Santos R, Martorell L, Menchón JM, Roca M, Sáiz-Ruiz J, Sanjuán J, Torrens M, Urretavizcaya M, Valero J, Vilella E, Estivill X, Carracedo A | display-authors = 6 | title = Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment | journal = American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics | volume = 150B | issue = 6 | pages = 808–16 | date = September 2009 | pmid = 19086053 | doi = 10.1002/ajmg.b.30902 | s2cid = 44524739 | doi-access = free }}
  • {{cite journal | vauthors = Bartels CF, Bükülmez H, Padayatti P, Rhee DK, van Ravenswaaij-Arts C, Pauli RM, Mundlos S, Chitayat D, Shih LY, Al-Gazali LI, Kant S, Cole T, Morton J, Cormier-Daire V, Faivre L, Lees M, Kirk J, Mortier GR, Leroy J, Zabel B, Kim CA, Crow Y, Braverman NE, van den Akker F, Warman ML | display-authors = 6 | title = Mutations in the transmembrane natriuretic peptide receptor NPR-B impair skeletal growth and cause acromesomelic dysplasia, type Maroteaux | journal = American Journal of Human Genetics | volume = 75 | issue = 1 | pages = 27–34 | date = July 2004 | pmid = 15146390 | pmc = 1182004 | doi = 10.1086/422013 }}
  • {{cite journal | vauthors = van den Akker F | title = Structural insights into the ligand binding domains of membrane bound guanylyl cyclases and natriuretic peptide receptors | journal = Journal of Molecular Biology | volume = 311 | issue = 5 | pages = 923–37 | date = August 2001 | pmid = 11556325 | doi = 10.1006/jmbi.2001.4922 }}

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