NPTX2

This gene encodes a member of the family of neuronal pentraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells.

Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD

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• {{cite journal |vauthors=Park JK, Ryu JK, Lee KH, etal |title=Quantitative analysis of NPTX2 hypermethylation is a promising molecular diagnostic marker for pancreatic cancer. |journal=Pancreas |volume=35 |issue= 3 |pages= e9–15 |year= 2007 |pmid= 17895837 |doi= 10.1097/MPA.0b013e318153fa42 |s2cid=31006962 }}
• {{cite journal |vauthors=Marui T, Koishi S, Funatogawa I, etal |title=No association between the neuronal pentraxin II gene polymorphism and autism. |journal=Prog. Neuropsychopharmacol. Biol. Psychiatry |volume=31 |issue= 4 |pages= 940–3 |year= 2007 |pmid= 17408830 |doi= 10.1016/j.pnpbp.2007.02.016 |s2cid=23877321 }}
• {{cite journal |vauthors=Poulsen TT, Pedersen N, Perin MS, etal |title=Specific sensitivity of small cell lung cancer cell lines to the snake venom toxin taipoxin |journal=Lung Cancer |volume=50 |issue= 3 |pages= 329–37 |year= 2006 |pmid= 16115696 |doi= 10.1016/j.lungcan.2005.06.011 }}
• {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
• {{cite journal |vauthors=Hillier LW, Fulton RS, Fulton LA, etal |title=The DNA sequence of human chromosome 7 |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 |bibcode=2003Natur.424..157H |doi-access= free }}
• {{cite journal |vauthors=Scherer SW, Cheung J, MacDonald JR, etal |title=Human Chromosome 7: DNA Sequence and Biology |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 | pmc=2882961 |bibcode=2003Sci...300..767S }}
• {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
• {{cite journal | vauthors=Kirkpatrick LL, Matzuk MM, Dodds DC, Perin MS |title=Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2 |journal=J. Biol. Chem. |volume=275 |issue= 23 |pages= 17786–92 |year= 2000 |pmid= 10748068 |doi= 10.1074/jbc.M002254200 |doi-access= free }}
• {{cite journal |vauthors=Dodds DC, Omeis IA, Cushman SJ, etal |title=Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49 |journal=J. Biol. Chem. |volume=272 |issue= 34 |pages= 21488–94 |year= 1997 |pmid= 9261167 |doi=10.1074/jbc.272.34.21488 |doi-access=free }}

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