NRCAM
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Neuronal cell adhesion molecule is a protein that in humans is encoded by the NRCAM gene.{{cite journal | vauthors = Lane RP, Chen XN, Yamakawa K, Vielmetter J, Korenberg JR, Dreyer WJ | title = Characterization of a highly conserved human homolog to the chicken neural cell surface protein Bravo/Nr-CAM that maps to chromosome band 7q31 | journal = Genomics | volume = 35 | issue = 3 | pages = 456–65 |date=Dec 1996 | pmid = 8812479 | doi = 10.1006/geno.1996.0385 }}{{cite web | title = Entrez Gene: NRCAM neuronal cell adhesion molecule| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4897}}
Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism{{cite journal |journal= Int J Neuropsychopharmacol |year=2008 |title= Association of the neuronal cell adhesion molecule (NRCAM) gene variants with autism |vauthors=Marui T, Funatogawa I, Koishi S, etal |doi=10.1017/S1461145708009127 |pmid=18664314 |volume= 12 |issue= 1 |pages= 1–10|doi-access= free }} and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms.
References
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Further reading
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- {{cite journal | author=Grumet M |title=Nr-CAM: a cell adhesion molecule with ligand and receptor functions |journal=Cell Tissue Res. |volume=290 |issue= 2 |pages= 423–8 |year= 1997 |pmid= 9321706 |doi=10.1007/s004410050949 |s2cid=24012715 }}
- {{cite journal |vauthors=Sakurai T, Lustig M, Nativ M, etal |title=Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase beta |journal=J. Cell Biol. |volume=136 |issue= 4 |pages= 907–18 |year= 1997 |pmid= 9049255 |doi=10.1083/jcb.136.4.907 | pmc=2132488 }}
- {{cite journal |vauthors=Nagase T, Ishikawa K, Nakajima D, etal |title=Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro |journal=DNA Res. |volume=4 |issue= 2 |pages= 141–50 |year= 1997 |pmid= 9205841 |doi=10.1093/dnares/4.2.141 |doi-access=free }}
- {{cite journal |vauthors=Wang B, Williams H, Du JS, etal |title=Alternative splicing of human NrCAM in neural and nonneural tissues |journal=Mol. Cell. Neurosci. |volume=10 |issue= 5–6 |pages= 287–95 |year= 1998 |pmid= 9604207 |doi= 10.1006/mcne.1997.0658 |s2cid=12028546 }}
- {{cite journal | vauthors=Moré MI, Kirsch FP, Rathjen FG |title=Targeted ablation of NrCAM or ankyrin-B results in disorganized lens fibers leading to cataract formation |journal=J. Cell Biol. |volume=154 |issue= 1 |pages= 187–96 |year= 2001 |pmid= 11449000 |doi=10.1083/jcb.200104038 | pmc=2196853 }}
- {{cite journal | vauthors=Dry K, Kenwrick S, Rosenthal A, Platzer M |title=The complete sequence of the human locus for NgCAM-related cell adhesion molecule reveals a novel alternative exon in chick and man and conserved genomic organization for the L1 subfamily |journal=Gene |volume=273 |issue= 1 |pages= 115–22 |year= 2001 |pmid= 11483367 |doi=10.1016/S0378-1119(01)00493-0 }}
- {{cite journal | vauthors=Jenkins SM, Bennett V |title=Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments |journal=J. Cell Biol. |volume=155 |issue= 5 |pages= 739–46 |year= 2002 |pmid= 11724816 |doi= 10.1083/jcb.200109026 | pmc=2150881 }}
- {{cite journal |vauthors=Aitkenhead M, Wang SJ, Nakatsu MN, etal |title=Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM |journal=Microvascular Research |volume=63 |issue= 2 |pages= 159–71 |year= 2002 |pmid= 11866539 |doi= 10.1006/mvre.2001.2380 }}
- {{cite journal |vauthors=Pavlou O, Theodorakis K, Falk J, etal |title=Analysis of interactions of the adhesion molecule TAG-1 and its domains with other immunoglobulin superfamily members |journal=Mol. Cell. Neurosci. |volume=20 |issue= 3 |pages= 367–81 |year= 2002 |pmid= 12139915 |doi=10.1006/mcne.2002.1105 |s2cid=714233 }}
- {{cite journal |vauthors=Conacci-Sorrell ME, Ben-Yedidia T, Shtutman M, etal |title=Nr-CAM is a target gene of the beta-catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis |journal=Genes Dev. |volume=16 |issue= 16 |pages= 2058–72 |year= 2002 |pmid= 12183361 |doi= 10.1101/gad.227502 | pmc=186445 }}
- {{cite journal | vauthors=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773–84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902 | pmc=187542 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Hillier LW, Fulton RS, Fulton LA, etal |title=The DNA sequence of human chromosome 7 |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 |bibcode=2003Natur.424..157H |doi-access= free }}
- {{cite journal |vauthors=Custer AW, Kazarinova-Noyes K, Sakurai T, etal |title=The role of the ankyrin-binding protein NrCAM in node of Ranvier formation |journal=J. Neurosci. |volume=23 |issue= 31 |pages= 10032–9 |year= 2003 |pmid= 14602817 |pmc=6740847 |doi= 10.1523/JNEUROSCI.23-31-10032.2003}}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
- {{cite journal |vauthors=Hutcheson HB, Olson LM, Bradford Y, etal |title=Examination of NRCAM, LRRN3, KIAA0716, and LAMB1 as autism candidate genes |journal=BMC Med. Genet. |volume=5|pages= 12 |year= 2004 |pmid= 15128462 |doi= 10.1186/1471-2350-5-12 | pmc=420465 |doi-access=free }}
- {{cite journal |vauthors=Bonora E, Lamb JA, Barnby G, etal |title=Mutation screening and association analysis of six candidate genes for autism on chromosome 7q |journal=Eur. J. Hum. Genet. |volume=13 |issue= 2 |pages= 198–207 |year= 2005 |pmid= 15523497 |doi= 10.1038/sj.ejhg.5201315 |doi-access= free }}
- {{cite journal |vauthors=Ishiguro H, Liu QR, Gong JP, etal |title=NrCAM in addiction vulnerability: positional cloning, drug-regulation, haplotype-specific expression, and altered drug reward in knockout mice |journal=Neuropsychopharmacology |volume=31 |issue= 3 |pages= 572–84 |year= 2006 |pmid= 16123759 |doi= 10.1038/sj.npp.1300855 |doi-access= free }}
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{{Cell adhesion molecules}}
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