NSF

• National Socialist Front, a Swedish National Socialist party
• NS-Frauenschaft, the women's wing of the former German Nazi party
• National Students Federation, a leftist Pakistani students' political group
• Norsk Syndikalistisk Forbund, a Norwegian anarcho-syndicalist group
• National Salvation Front (disambiguation), various organizations
• National Secessionist Forces, a fictional rebel group in the video game Deus Ex

• Naga Students' Federation, student organization of the Naga people
• National Science Foundation, a United States government agency
• National Service Framework, one of various British health policies
• National Sleep Foundation, a U.S. nonprofit organization that promotes public understanding of sleep and sleep disorders
• NSF International, formerly the National Sanitation Foundation at the University of Michigan, a food safety standards group
• North Sea Fleet
• Nykterhetsrörelsens Scoutförbund, a Swedish scouting organization
• Norges Speiderforbund, a Norwegian scouting organization
• Palestinian National Security Forces
• NASASpaceFlight.com, a news website and forum covering spaceflight and aerospace engineering news
• {{Ill|Nederlandsche Seintoestellen Fabriek|nl}}, defunct radio and television transmitter company in the Netherlands

• Nephrogenic systemic fibrosis, a disease
• N-ethylmaleimide sensitive fusion protein, an enzyme and gene

• NES Sound Format (.nsf), an audio file format for the Nintendo Entertainment System
• Notes Storage Facility (.nsf), the file type for IBM Lotus Notes databases

• Non-sufficient funds, a cause for a bank to reject a check
• New Small Family, an automobile model range
• National Service Full-time, a type of conscription in Singapore
• Thiazyl fluoride, an unstable gas with the chemical formula NSF
• NSF, one of the call signs used by the radio station at the Anacostia Naval Air Station in Washington, D.C.

{{Disambiguation|political}}