NSFL1C

{{Short description|Protein-coding gene in the species Homo sapiens}}

NSFL1 cofactor p47 is a protein that in humans is encoded by the NSFL1C gene.{{cite journal |vauthors=Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z | title = Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells | journal = Genome Res | volume = 10 | issue = 10 | pages = 1546–60 |date=Nov 2000 | pmid = 11042152 | pmc = 310934 | doi =10.1101/gr.140200 }}{{cite web | title = Entrez Gene: NSFL1C NSFL1 (p97) cofactor (p47)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55968| accessdate = }}

N-ethylmaleimide-sensitive factor (NSF) and valosin-containing protein (p97) are two ATPases known to be involved in transport vesicle/target membrane fusion and fusions between membrane compartments. A trimer of the protein encoded by this gene binds a hexamer of cytosolic p97 and is required for p97-mediated regrowth of Golgi cisternae from mitotic Golgi fragments. Multiple transcript variants encoding several different isoforms have been found for this gene.

Interactions

NSFL1C has been shown to interact with Valosin-containing protein.{{cite journal |last=Uchiyama |first=Keiji |author2=Jokitalo Eija |author3=Lindman Mervi |author4=Jackman Mark |author5=Kano Fumi |author6=Murata Masayuki |author7=Zhang Xiaodong |author8=Kondo Hisao |date=Jun 2003 |title=The localization and phosphorylation of p47 are important for Golgi disassembly–assembly during the cell cycle |journal=J. Cell Biol. |volume=161 |issue=6 |pages=1067–79 |location = United States| issn = 0021-9525| pmid = 12810701 |doi = 10.1083/jcb.200303048 |pmc=2173005 }}

References

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NSFL1C

Interactions

References

Further reading