NUDT4
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Diphosphoinositol polyphosphate phosphohydrolase 2 is an enzyme that in humans is encoded by the NUDT4 gene.{{cite journal |vauthors=Caffrey JJ, Safrany ST, Yang X, Shears SB | title = Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt family | journal = J Biol Chem | volume = 275 | issue = 17 | pages = 12730–6 |date=Jun 2000 | pmid = 10777568 | doi =10.1074/jbc.275.17.12730 | doi-access = free }}{{cite journal |vauthors=Caffrey JJ, Shears SB | title = Genetic rationale for microheterogeneity of human diphosphoinositol polyphosphate phosphohydrolase type 2 | journal = Gene | volume = 269 | issue = 1–2 | pages = 53–60 |date=May 2001 | pmid = 11376937 | doi =10.1016/S0378-1119(01)00446-2 | url = https://zenodo.org/record/1260047 }}{{cite web | title = Entrez Gene: NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11163}}
The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to regulating intracellular trafficking. Several alternatively spliced transcript variants have been described, but the full-length nature of some variants has not been determined. Isoforms DIPP2alpha and DIPP2beta are distinguishable from each other solely by DIPP2beta possessing one additional amino acid due to intron boundary skidding in alternate splicing.
References
{{reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
- {{cite journal | author=Suzuki Y |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |name-list-style=vanc| author2=Yoshitomo-Nakagawa K | author3=Maruyama K | display-authors=3 | last4=Suyama | first4=A | last5=Sugano | first5=S }}
- {{cite journal | author=Seki N |title=Characterization of cDNA clones in size-fractionated cDNA libraries from human brain |journal=DNA Res. |volume=4 |issue= 5 |pages= 345–9 |year= 1998 |pmid= 9455484 |doi=10.1093/dnares/4.5.345 |name-list-style=vanc| author2=Ohira M | author3=Nagase T | display-authors=3 | last4=Ishikawa | first4=K | last5=Miyajima | first5=N | last6=Nakajima | first6=D | last7=Nomura | first7=N | last8=Ohara | first8=O | doi-access=free }}
- {{cite journal |vauthors=Leslie NR, McLennan AG, Safrany ST |title=Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases |journal=BMC Biochem. |volume=3|pages= 20 |year= 2002 |pmid= 12121577 |doi=10.1186/1471-2091-3-20 | pmc=117780 |doi-access=free }}
- {{cite journal | author=Fisher DI |title=Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 47313–7 |year= 2003 |pmid= 12370170 |doi= 10.1074/jbc.M209795200 |name-list-style=vanc| author2=Safrany ST | author3=Strike P | display-authors=3 | last4=McLennan | first4=AG | last5=Cartwright | first5=JL |doi-access=free }}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | author=Fortna A |title=Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution |journal=PLOS Biol. |volume=2 |issue= 7 |pages= E207 |year= 2006 |pmid= 15252450 |doi= 10.1371/journal.pbio.0020207 | pmc=449870 |name-list-style=vanc| author2=Kim Y | author3=MacLaren E | display-authors=3 | last4=Marshall | first4=Kriste | last5=Hahn | first5=Gretchen | last6=Meltesen | first6=Lynne | last7=Brenton | first7=Matthew | last8=Hink | first8=Raquel | last9=Burgers | first9=Sonya |doi-access=free }}
- {{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
{{refend}}
{{PDB Gallery|geneid=11163}}
{{gene-12-stub}}