NUDT5
{{Short description|Protein-coding gene in the species Homo sapiens}}
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ADP-sugar pyrophosphatase is an enzyme that in humans is encoded by the NUDT5 gene.{{cite journal | author = McLennan AG | title = The MutT motif family of nucleotide phosphohydrolases in man and human pathogens (review) | journal = Int J Mol Med | volume = 4 | issue = 1 | pages = 79–89 |date=Aug 1999 | pmid = 10373642 | doi = 10.3892/ijmm.4.1.79}}{{cite web | title = Entrez Gene: NUDT5 nudix (nucleoside diphosphate linked moiety X)-type motif 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11164}}
Nudix hydrolases, such as NUDT5, eliminate toxic nucleotide derivatives from the cell and regulate the levels of important signaling nucleotides and their metabolites (McLennan, 1999).[supplied by OMIM]
References
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Further reading
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- {{cite journal |vauthors=Rush J, Moritz A, Lee KA, etal |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 |s2cid=7200157 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal | vauthors=Ishibashi T, Hayakawa H, Sekiguchi M |title=A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides |journal=EMBO Rep. |volume=4 |issue= 5 |pages= 479–83 |year= 2004 |pmid= 12717453 |doi= 10.1038/sj.embor.embor838 | pmc=1319193 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Zhang QH, Ye M, Wu XY, etal |title=Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=10.1101/gr.140200 | pmc=310934 }}
- {{cite journal |vauthors=Yang H, Slupska MM, Wei YF, etal |title=Cloning and characterization of a new member of the Nudix hydrolases from human and mouse |journal=J. Biol. Chem. |volume=275 |issue= 12 |pages= 8844–53 |year= 2000 |pmid= 10722730 |doi=10.1074/jbc.275.12.8844 |doi-access=free }}
- {{cite journal | vauthors=Gasmi L, Cartwright JL, McLennan AG |title=Cloning, expression and characterization of YSA1H, a human adenosine 5'-diphosphosugar pyrophosphatase possessing a MutT motif |journal=Biochem. J. |volume=344 Pt 2 |issue= Pt 2|pages= 331–7 |year= 2000 |pmid= 10567213 |doi= 10.1042/0264-6021:3440331| pmc=1220648 }}
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