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NUMBL

{{Short description|Protein-coding gene in the species Homo sapiens}}

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Numb-like protein is a protein that in humans is encoded by the NUMBL gene.{{cite journal |vauthors=Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA | title = cDNAs with long CAG trinucleotide repeats from human brain | journal = Hum Genet | volume = 100 | issue = 1 | pages = 114–22 |date=Jul 1997 | pmid = 9225980 | doi =10.1007/s004390050476 | s2cid = 25999127 }}{{cite journal |vauthors=Salcini AE, Confalonieri S, Doria M, Santolini E, Tassi E, Minenkova O, Cesareni G, Pelicci PG, Di Fiore PP | title = Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module | journal = Genes Dev | volume = 11 | issue = 17 | pages = 2239–49 |date=Oct 1997 | pmid = 9303539 | pmc = 275390 | doi =10.1101/gad.11.17.2239 }}{{cite web | title = Entrez Gene: NUMBL numb homolog (Drosophila)-like| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9253}}

Interactions

NUMBL has been shown to interact with MAP3K7IP2.{{cite journal |last=Ma |first=Qi |author2=Zhou Li |author3=Shi Huili |author4=Huo Keke |date=Jun 2008 |title=NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation |journal=Cell. Signal. |volume=20 |issue=6 |pages=1044–51 |location = England| issn = 0898-6568| pmid = 18299187 |doi = 10.1016/j.cellsig.2008.01.015 }}

References

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Further reading

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  • {{cite journal |vauthors=Wong WT, Schumacher C, Salcini AE, etal |title=A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 21 |pages= 9530–4 |year= 1995 |pmid= 7568168 |doi=10.1073/pnas.92.21.9530 | pmc=40835 |bibcode=1995PNAS...92.9530W |doi-access=free }}
  • {{cite journal |vauthors=Zhong W, Feder JN, Jiang MM, etal |title=Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis. |journal=Neuron |volume=17 |issue= 1 |pages= 43–53 |year= 1996 |pmid= 8755477 |doi=10.1016/S0896-6273(00)80279-2 |doi-access=free }}
  • {{cite journal |vauthors=Zhong W, Jiang MM, Weinmaster G, etal |title=Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis. |journal=Development |volume=124 |issue= 10 |pages= 1887–97 |year= 1997 |doi=10.1242/dev.124.10.1887 |pmid= 9169836 }}
  • {{cite journal |vauthors=Roncarati R, Sestan N, Scheinfeld MH, etal |title=The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 10 |pages= 7102–7 |year= 2002 |pmid= 12011466 |doi= 10.1073/pnas.102192599 | pmc=124535 |bibcode=2002PNAS...99.7102R |doi-access=free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Jin J, Smith FD, Stark C, etal |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 |doi-access= free |bibcode=2004CBio...14.1436J }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |doi-access= free }}
  • {{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |doi-access= free }}

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