NUTF2

The protein encoded by this gene is a cytosolic factor that facilitates protein transport into the nucleus. It interacts with the nuclear pore complex glycoprotein p62. This encoded protein acts at a relative late stage of nuclear protein import, subsequent to the initial docking of nuclear import ligand at the nuclear envelope. It is thought to be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import.

NUTF2 has been shown to interact with Nucleoporin 62{{cite journal | vauthors = Hu T, Guan T, Gerace L | title = Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins | journal = J. Cell Biol. | volume = 134 | issue = 3 | pages = 589–601 | date = Aug 1996 | pmid = 8707840 | pmc = 2120945 | doi = 10.1083/jcb.134.3.589 }} and RAN.{{cite journal | vauthors = Cushman I, Bowman BR, Sowa ME, Lichtarge O, Quiocho FA, Moore MS | title = Computational and biochemical identification of a nuclear pore complex binding site on the nuclear transport carrier NTF2 | journal = J. Mol. Biol. | volume = 344 | issue = 2 | pages = 303–310 | date = Nov 2004 | pmid = 15522285 | doi = 10.1016/j.jmb.2004.09.043 }}{{cite journal | vauthors = Stewart M, Kent HM, McCoy AJ | title = Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran | journal = J. Mol. Biol. | volume = 277 | issue = 3 | pages = 635–646 | date = Apr 1998 | pmid = 9533885 | doi = 10.1006/jmbi.1997.1602 }}

{{reflist}}

{{Clear}}

{{refbegin | 2}}

• {{cite journal | vauthors = Bukrinsky MI, Haffar OK | title = HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr | journal = Mol. Med. | volume = 4 | issue = 3 | pages = 138–43 | year = 1998 | pmid = 9562972 | pmc = 2230352 | doi = 10.1007/BF03401911}}
• {{cite journal | vauthors = Stewart M | title = Insights into the molecular mechanism of nuclear trafficking using nuclear transport factor 2 (NTF2) | journal = Cell Struct. Funct. | volume = 25 | issue = 4 | pages = 217–225 | year = 2001 | pmid = 11129791 | doi = 10.1247/csf.25.217 | doi-access = free }}
• {{cite journal | vauthors = Bohn H, Johannsen R, Kraus W | title = [New placental protein (PP15) with immunosuppressive properties (author's transl)] | journal = Arch. Gynecol. | volume = 230 | issue = 2 | pages = 167–72 | year = 1981 | pmid = 7458421 | doi = 10.1007/BF02108272| s2cid = 9104166 }}
• {{cite journal | vauthors = Hu T, Guan T, Gerace L | title = Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins | journal = J. Cell Biol. | volume = 134 | issue = 3 | pages = 589–601 | year = 1996 | pmid = 8707840 | pmc = 2120945 | doi = 10.1083/jcb.134.3.589 }}
• {{cite journal | vauthors = Bullock TL, Clarkson WD, Kent HM, Stewart M | title = The 1.6 angstroms resolution crystal structure of nuclear transport factor 2 (NTF2) | journal = J. Mol. Biol. | volume = 260 | issue = 3 | pages = 422–431 | year = 1996 | pmid = 8757804 | doi = 10.1006/jmbi.1996.0411 }}
• {{cite journal | vauthors = Clarkson WD, Corbett AH, Paschal BM, Kent HM, McCoy AJ, Gerace L, Silver PA, Stewart M | title = Nuclear protein import is decreased by engineered mutants of nuclear transport factor 2 (NTF2) that do not bind GDP-Ran | journal = J. Mol. Biol. | volume = 272 | issue = 5 | pages = 716–730 | year = 1997 | pmid = 9368653 | doi = 10.1006/jmbi.1997.1255 }}
• {{cite journal | vauthors = Stewart M, Kent HM, McCoy AJ | title = Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran | journal = J. Mol. Biol. | volume = 277 | issue = 3 | pages = 635–646 | year = 1998 | pmid = 9533885 | doi = 10.1006/jmbi.1997.1602 }}
• {{cite journal | vauthors = Ribbeck K, Lipowsky G, Kent HM, Stewart M, Görlich D | title = NTF2 mediates nuclear import of Ran | journal = EMBO J. | volume = 17 | issue = 22 | pages = 6587–6598 | year = 1999 | pmid = 9822603 | pmc = 1171005 | doi = 10.1093/emboj/17.22.6587 }}
• {{cite journal | vauthors = Steggerda SM, Black BE, Paschal BM | title = Monoclonal antibodies to NTF2 inhibit nuclear protein import by preventing nuclear translocation of the GTPase Ran | journal = Mol. Biol. Cell | volume = 11 | issue = 2 | pages = 703–19 | year = 2000 | pmid = 10679025 | pmc = 14804 | doi = 10.1091/mbc.11.2.703 }}
• {{cite journal | vauthors = Freire J, Covelo G, Sarandeses C, Díaz-Jullien C, Freire M | title = Identification of nuclear-import and cell-cycle regulatory proteins that bind to prothymosin alpha | journal = Biochem. Cell Biol. | volume = 79 | issue = 2 | pages = 123–131 | year = 2001 | pmid = 11310559 | doi = 10.1139/bcb-79-2-123 }}
• {{cite journal | vauthors = Cushman I, Bowman BR, Sowa ME, Lichtarge O, Quiocho FA, Moore MS | title = Computational and biochemical identification of a nuclear pore complex binding site on the nuclear transport carrier NTF2 | journal = J. Mol. Biol. | volume = 344 | issue = 2 | pages = 303–310 | year = 2004 | pmid = 15522285 | doi = 10.1016/j.jmb.2004.09.043 }}
• {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–1178 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }}

{{refend}}

• {{UCSC genome browser|NUTF2}}
• {{UCSC gene details|NUTF2}}

{{PDB Gallery|geneid=10204}}

{{protein-stub}}