NXF2
{{Short description|Protein-coding gene in the species Homo sapiens}}
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Nuclear RNA export factor 2 is a protein that in humans is encoded by the NXF2 gene.{{cite journal | vauthors = Herold A, Suyama M, Rodrigues JP, Braun IC, Kutay U, Carmo-Fonseca M, Bork P, Izaurralde E | title = TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture | journal = Molecular and Cellular Biology | volume = 20 | issue = 23 | pages = 8996–9008 | date = Dec 2000 | pmid = 11073998 | pmc = 86553 | doi = 10.1128/MCB.20.23.8996-9008.2000 }}{{cite journal | vauthors = Wang PJ, McCarrey JR, Yang F, Page DC | title = An abundance of X-linked genes expressed in spermatogonia | journal = Nature Genetics | volume = 27 | issue = 4 | pages = 422–426 | date = Apr 2001 | pmid = 11279525 | doi = 10.1038/86927 | s2cid = 14200121 }}{{cite web | title = Entrez Gene: NXF2 nuclear RNA export factor 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56001}}
Function
This gene is one of a family of nuclear RNA export factor genes. It encodes a protein that is involved in mRNA export, is located in the nucleoplasm, and is associated with the nuclear envelope. Alternative splicing seems to be a common mechanism in this gene family. Two variants have been found for this gene.
Interactions
References
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Further reading
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- {{cite journal | vauthors = Black BE, Lévesque L, Holaska JM, Wood TC, Paschal BM | title = Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export | journal = Molecular and Cellular Biology | volume = 19 | issue = 12 | pages = 8616–24 | date = Dec 1999 | pmid = 10567585 | pmc = 84993 | doi = 10.1128/MCB.19.12.8616}}
- {{cite journal | vauthors = Jun L, Frints S, Duhamel H, Herold A, Abad-Rodrigues J, Dotti C, Izaurralde E, Marynen P, Froyen G | title = NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation | journal = Current Biology | volume = 11 | issue = 18 | pages = 1381–1391 | date = Sep 2001 | pmid = 11566096 | doi = 10.1016/S0960-9822(01)00419-5 | doi-access = free | bibcode = 2001CBio...11.1381J }}
- {{cite journal|author-link30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–1178 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }}
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