Nagasuma Chandra

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Nagasuma Chandra, born in the south Indian state of Karnataka, completed her undergraduate (BPharm) and post-graduate (MPharm) studies at the Bangalore University and moved to the UK from where she secured a PhD from the University of Bristol in 1992.{{Cite web |url=https://selectbiosciences.com/conferences/biographies.aspx?speaker=346018&conf=ddi2017&se=india |title=Drug Discovery India 2017 Speaker Biography |date=2018-01-17 |website=SELECTBIO |access-date=2018-01-17}} She did her post-doctoral work at the Molecular Biophysics Unit (MBU) of the Indian Institute of Sciences (IISc) from 1992 to 1997 and joined IISc as a research scientist the same year.{{Cite web |url=http://www.biochem.iisc.ernet.in/nchandra.php |title=Faculty profile |website=www.biochem.iisc.ernet.in |language=en |access-date=2018-01-17 |archive-date=17 January 2018 |archive-url=https://web.archive.org/web/20180117022251/http://www.biochem.iisc.ernet.in/nchandra.php |url-status=dead }} A year later, she became a faculty of bioinformatics of the institute{{Cite journal |last1=Raman |first1=Karthik |last2=Chandra |first2=Nagasuma |date=2010-02-01 |title=Systems biology |journal=Resonance |language=en |volume=15 |issue=2 |pages=131–153 |doi=10.1007/s12045-010-0015-7 |s2cid=195299490 |issn=0971-8044|url=https://www.zora.uzh.ch/id/eprint/156224/1/ZORA_NL_156224.pdf }} where she holds the position of a professor. At IISc, she has set up a systems biology and computational biochemistry laboratory, popularly known as Chandralab,{{Cite web |url=http://proline.physics.iisc.ernet.in/chandralab/ |title=Chandra Lab - Department of Biochemistry |website=proline.physics.iisc.ernet.in |language=en |access-date=2018-01-17}} and hosts several research scholars.{{Cite web |url=http://proline.physics.iisc.ernet.in/chandralab/team.php |title=Chandra Lab - Team |date=2018-01-17 |website=proline.physics.iisc.ernet.in |language=en |access-date=2018-01-17}} She also serves as a faculty at the National Network for Mathematical and Computational Biology, an educational agency funded by the Science and Engineering Research Board of the Government of India.{{Cite web |url=http://www.iiserpune.ac.in/~mbio/?q=nnmcb/people/nagasuma-chandra |title=Nagasuma Chandra - National Network for Mathematical and Computational Biology |website=www.iiserpune.ac.in |language=en |access-date=2018-01-17}}

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Chandra's research focus is in the fields of computational systems biology, cell modeling and structural bioinformatics and she leads a team of scientists who are involved in research in areas such as systems biology, computational immunology, structural bioinformatics and drug discovery. She has carried out studies on Mycobacterium tuberculosis, the causative pathogen of tuberculosis, with special emphasis on their metabolic processes and, along with M. Vijayan and K. Sekar, two of her colleagues at IISc,{{cite book|author1=D. P. Burma|author2=Maharani Chakravorty|title=From Physiology and Chemistry to Biochemistry|url=https://books.google.com/books?id=4CaQ3-x3LXMC&pg=PA389|year=2011|publisher=Pearson Education India|isbn=978-81-317-3220-5|pages=389–}} has developed system models which has helped identify new drug targets against the disease.{{Cite web |url=http://bio.iisc.ac.in/?q=faculty/nagasuma-chandra |title=Nagasuma Chandra - Division of Biological Sciences, Indian Institute of Science |date=2018-01-17 |website=bio.iisc.ac.in |access-date=2018-01-17}} In 2017, the team led by her identified three drugs namely Ebselen, Vancomycin and Phenylarsine oxide that could be used in combination with Isoniazid, the principal antibiotic used against tuberculosis, to treat the drug-resistant strains of the pathogen.{{Cite news |url=https://researchmatters.in/article/scientists-find-ways-reverse-drug-resistance-major-burden-treating-tuberculosis |title=Scientists find ways to reverse drug resistance, a major burden in treating Tuberculosis |date=2017-02-08 |work=Research Matters |access-date=2018-01-17 |language=en}} The team discovered that the three drugs lowered the antioxidant levels in the bacterium and thereby destroyed its drug-resistance.{{Cite news |url=http://bangaloremirror.indiatimes.com/bangalore/others/city-scientists-deliver-killer-punch-to-drug-resistant-tb/articleshow/57997366.cms |title=City scientists deliver killer punch to drug-resistant TB |work=Bangalore Mirror |access-date=2018-01-17}} Her studies have been documented by way of a number of articles{{Cite web |url=https://scholar.google.co.in/citations?user=BG3m00QAAAAJ |title=On Google Scholar |date=2018-01-08 |publisher=Google Scholar |access-date=2018-01-08}}{{Refn|group=note|Please see Selected bibliography section}} and ResearchGate, an online repository of scientific articles has listed 297 of them.{{Cite web |url=https://www.researchgate.net/profile/Nagasuma_Chandra2 |title=On ResearchGate |date=2018-01-09 |access-date=2018-01-09}} She has also delivered invited speeches at various seminars and conferences.{{Cite web |url=http://www.rcb.res.in/upload/2013/Workshop2013_12.pdf |title=Systems biology and protein interaction network |date=2018-01-17 |website=Regional Centre for Biotechnology |access-date=2018-01-17}}

The Department of Biotechnology of the Government of India awarded her the National Bioscience Award for Career Development, one of the highest Indian science awards in 2008.{{Cite web |url=http://dbtindia.nic.in/wp-content/uploads/2014/03/list_of_bioscience_awardees.pdf |title=Awardees of National Bioscience Awards for Career Development |date=2016 |publisher=Department of Biotechnology |access-date=2017-11-20 |archive-date=4 March 2018 |archive-url=https://web.archive.org/web/20180304191331/http://dbtindia.nic.in/wp-content/uploads/2014/03/list_of_bioscience_awardees.pdf |url-status=dead }}

• {{cite journal | last1=Bhagavat | first1=Raghu | last2=Sankar | first2=Santhosh | last3=Srinivasan | first3=Narayanaswamy | last4=Chandra | first4=Nagasuma | title=An Augmented Pocketome: Detection and Analysis of Small-Molecule Binding Pockets in Proteins of Known 3D Structure | journal=Structure | publisher=Elsevier BV | volume=26 | issue=3 | year=2018 | issn=0969-2126 | doi=10.1016/j.str.2018.02.001 | pages=499–512.e2 |display-authors=1|pmid=29514079| doi-access=free }}
• {{Cite journal |last1=Anand |first1=Praveen |last2=Chandra |first2=Nagasuma |date=2014-09-15 |title=Characterizing the pocketome of Mycobacterium tuberculosis and application in rationalizing polypharmacological target selection |journal=Scientific Reports |language=En |volume=4 |issue=1 |pages=6356 |doi=10.1038/srep06356 |pmid=25220818 |pmc=5376175 |bibcode=2014NatSR...4E6356A |issn=2045-2322}}
• {{Cite journal |last1=Chandra |first1=Nagasuma |last2=Padiadpu |first2=Jyothi |title=Network approaches to drug discovery |journal=Expert Opinion on Drug Discovery |volume=8 |issue=1 |pages=7–20 |doi=10.1517/17460441.2013.741119|pmid=23140510 |year=2013 |s2cid=21595087 }}
• {{Cite journal |last1=Bhagavat |first1=Raghu |last2=Chandra |first2=Nagasuma |date=2014-01-01 |title=Common recognition principles across diverse sequence and structural families of sialic acid binding proteins |url=https://academic.oup.com/glycob/article/24/1/5/1988383 |journal=Glycobiology |volume=24 |issue=1 |pages=5–16 |doi=10.1093/glycob/cwt063 |pmid=24043392 |issn=0959-6658|doi-access=free }}

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• Genome analysis
• Human iron metabolism

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{{portal|India|Biology|Medicine}}

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• {{Cite web |url=https://www.youtube.com/watch?v=rKITRrlY-Xc |title=Can biology be a predictive science ? |last=Nagasuma Chandra |date=4 May 2017 |publisher= IISc Naturalists |format=YouTube video |access-date=2018-01-17}}

{{N-BIOS Laureates 1999–2009}}

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Category:N-BIOS Prize recipients

Category:Living people

Category:Indian Institute of Science alumni

Category:Indian molecular biologists

Category:Scientists from Bengaluru

Category:Indian bioinformaticians

Category:Indian biochemists

Category:Bangalore University alumni

Category:Alumni of the University of Bristol

Category:Academic staff of the Indian Institute of Science

Category:Year of birth missing (living people)