Nagy Habib
{{Short description|Egyptian professor of surgery}}
{{EngvarB|date=October 2016}}
{{Use dmy dates|date=October 2016}}
{{Infobox medical person
| honorific_prefix =
| name = Nagy Habib
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| image = Nagy Habib.jpg
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| caption = Nagy Habib (2021)
| birth_name =
| birth_date = {{Birth year and age|1952}}
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| nationality = British, Egyptian
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| occupation = Surgeon
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| known_for = Radio-frequency based surgical devices
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| profession = Liver surgeon
| field =
| work_institutions = Imperial College, London
| specialism =
| research_field = *Oncolytic adenoviruses
- Liver cancer treatments
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Nagy Habib (born 1952) is a British-Egyptian professor of hepato-biliary surgery at Imperial College, London, and is known for devising radio-frequency based liver resection devices which remove liver tumour with minimal blood loss. His work has also focused on stem cells and gene therapy.
Early life and education
Nagy Habib was born in Cairo, Egypt, 1952.{{Cite web|title=Habib Nagy / Curriculum Vitae|url=http://www.s466593873.onlinehome.fr/site%20institut/html/maitre/habib_gb.htm|access-date=2021-11-28|website=www.s466593873.onlinehome.fr}} He trained under both {{ill|Henri Bismuth|fr}} and the transplant surgeon Thomas Starzl.{{cite web |title=Interview with Nagy Habib |url=https://www.oligotherapeutics.org/interview-with-nagy-habib/ |archive-url=https://web.archive.org/web/20211129153415/https://www.oligotherapeutics.org/interview-with-nagy-habib/|archive-date=29 November 2021|website=Oligonucleutide Therapeutic Society |access-date=27 November 2021 |date=8 January 2019}}
Career
His work has focused on stem cells and gene therapy.{{cite journal |last1=Sugand |first1=Kapil |last2=Hills |first2=Alexander |title=Professor Nagy Habib |journal=British Medical Journal |date=22 March 2008 |volume=336 |issue=7645 |pages=s109 |doi=10.1136/bmj.39510.543056.CE |s2cid=80337462 |url=https://www.bmj.com/content/336/7645/s109 |language=en |issn=0959-8138|url-access=subscription }} He led the first clinical trial in the use of oncolytic adenoviruses for the treatment of liver cancer.{{cite web |title=Home - Professor Nagy Habib |url=https://www.imperial.ac.uk/people/nagy.habib |archive-url=https://web.archive.org/web/20211127172832/https://www.imperial.ac.uk/people/nagy.habib|archive-date=27 November 2021|website=www.imperial.ac.uk |access-date=27 November 2021}} It was carried out by means of a locally restricted injection into the main blood vessel to the liver.{{cite book |last1=Doerfler |first1=Walter |last2=Böhm |first2=Petra |title=Adenoviruses: Model and Vectors in Virus-Host Interactions: Immune System, Oncogenesis, Gene Therapy |date=2013 |publisher=Springer |isbn=978-3-662-05599-1 |pages=316–320 |url=https://books.google.com/books?id=WWr7CAAAQBAJ&dq=habib+adenovirus&pg=PA316 |language=en}}{{cite journal |last1=Avila |first1=M. A. |last2=Berasain |first2=C. |last3=Sangro |first3=B. |last4=Prieto |first4=J. |title=New therapies for hepatocellular carcinoma |journal=Oncogene |date=June 2006 |volume=25 |issue=27 |pages=3866–3884 |doi=10.1038/sj.onc.1209550 |pmid=6799628 |hdl=10171/27496 |s2cid=8901643 |url=https://www.nature.com/articles/1209550 |language=en |issn=1476-5594|hdl-access=free }} The findings were published in 2001. It was found to be safe, but the second phase of the trial did not find it effective. In 2004, he took stem cells from a person with liver cirrhosis and injected them into their liver artery, resulting in some improvement of liver function.{{cite book |last1=Nill |first1=Kimball |title=Glossary of Biotechnology Terms, Fourth Edition |date=2005 |publisher=CRC Press |location=Boca Raton |isbn=0-8493-6609-7 |page=9 |edition=4th |url=https://books.google.com/books?id=GlLMBQAAQBAJ&dq=Nagy+Habib&pg=PA9 |language=en}}
In 2003 he was appointed professor of hepato-biliary surgery at Imperial College, London.{{cite web |title=Professor Nagy Habib |url=https://www.imperial.nhs.uk/consultant-directory/nagy-habib |archive-url=https://web.archive.org/web/20211129153845/https://www.imperial.nhs.uk/consultant-directory/nagy-habib|archive-date=29 November 2021|website=www.imperial.nhs.uk |access-date=28 November 2021 |language=en}} In June 2007 he was appointed pro-rector for Commercial Affairs at Imperial.
Habib developed several radio-frequency (RF) based liver resection devices.{{cite book |last1=Krestanova |first1=Alice |last2=Kracmar |first2=Jan |last3=Hlavackova |first3=Milada |last4=Kubicek |first4=Jan |last5=Vavra |first5=Petr |last6=Penhaker |first6=Marek |last7=Ihnat |first7=Petr |editor1-last=Pietka |editor1-first=Ewa |editor2-last=Badura |editor2-first=Pawel |editor3-last=Kawa |editor3-first=Jacek |editor4-last=Wieclawek |editor4-first=Wojciech |title=Information Technology in Biomedicine |date=2019 |publisher=Springer |isbn=978-3-030-23761-5 |page=638 |chapter-url=https://books.google.com/books?id=U0efDwAAQBAJ&dq=Nagy+Habib&pg=PA638 |language=en |chapter=Design and testing of radio frequency instrument RONLINE}}{{cite book |last1=Kumaran |first1=Vinay |title=Techniques of Liver Surgery |date=2016 |publisher=JP Medical Ltd |location=New Delhi |isbn=978-93-85891-56-4 |page=15 |chapter-url=https://books.google.com/books?id=C0iJDAAAQBAJ&dq=Nagy+Habib&pg=PA15 |language=en |chapter=2. Techniques for transection of the liver}} He devised the Habib RF device using the Habib needle, which has a modified version called the Habib 4X. It removes tumour with minimal blood loss. The procedure has come to be known as 'Habib's resection'.{{cite book |last1=Penhaker |first1=Marek |last2=Vavra |first2=Petr |last3=Hlavackova |first3=Mlada |last4=Kracmar |first4=Jan |last5=Sikora |first5=Tadeusz |last6=Prokop |first6=Lucas |editor1-last=Madarász |editor1-first=Ladislav |editor2-last=Živčák |editor2-first=Jozef |title=Aspects of Computational Intelligence: Theory and Applications: Revised and Selected Papers of the 15th IEEE International Conference on Intelligent Engineering Systems 2011, INES 2011 |date=2012 |publisher=Springer |isbn=978-3-642-30668-6 |page=308 |chapter-url=https://books.google.com/books?id=6UepGENufkoC&dq=Nagy+Habib&pg=PA308 |language=en |chapter=Linear surgical instrument for bipolar multi electrode radiofrquency ablation}}
MiNA Therapeutics, a biotechnology company dealing in small activating RNA technology was co-founded by Habib and his son Robert.{{cite news |last1=Ralph |first1=Alex |title=Father and son pioneers at MiNA Therapeutics clinch US pharma deal |url=https://www.thetimes.com/article/father-and-son-pioneers-at-mina-therapeutics-clinch-us-pharma-deal-nwd7fh7l9 |access-date=8 December 2021 |archive-url=https://web.archive.org/web/20211208063734/https://www.thetimes.co.uk/article/father-and-son-pioneers-at-mina-therapeutics-clinch-us-pharma-deal-nwd7fh7l9|archive-date=8 December 2021|work=The Times |date=12 May 2021 |url-status=live |language=en}}
Awards and honours
He was awarded the Takreem award in December 2012, for his work in liver cancer and radio-frequency based liver resection.
Selected publications
=Articles=
- {{cite journal |title=E1B-deleted adenovirus (dl1520) gene therapy for patients with primary and secondary liver tumors |journal=Human Gene Therapy |date=10 February 2001 |volume=12 |issue=3 |pages=219–226 |doi=10.1089/10430340150218369 |pmid=11177559 |url=https://pubmed.ncbi.nlm.nih.gov/11177559/ |issn=1043-0342|last1=Habib |first1=Nagy A. |last2=Sarraf |first2=Catherine E. |last3=Mitry |first3=Ragai R. |last4=Havlík |first4=Roman |last5=Nicholls |first5=Joanna |last6=Kelly |first6=Michael |last7=Vernon |first7=Clare C. |last8=Gueret-Wardle |first8=David |last9=El-Masry |first9=Rashad |last10=Salama |first10=Hosny |last11=Ahmed |first11=Rasha |last12=Michail |first12=Nagy |last13=Edward |first13=Ezzat |last14=Jensen |first14=Steen L. }} (Co-author)
- {{cite journal |title=Clinical trial of E1B-deleted adenovirus (dl1520) gene therapy for hepatocellular carcinoma |journal=Cancer Gene Therapy |date=March 2002 |volume=9 |issue=3 |pages=254–259 |doi=10.1038/sj.cgt.7700431 |url=https://www.nature.com/articles/7700431 |language=en |issn=1476-5500 |pmid=11896441 |s2cid=42290755 |last1=Habib |first1=Nagy |last2=Salama |first2=Hosny |last3=Abd El Latif Abu Median |first3=Ahmed |last4=Isac Anis |first4=Ilia |last5=Abd Al Aziz |first5=Rasha Ahmed |last6=Sarraf |first6=Catherine |last7=Mitry |first7=Ragai |last8=Havlik |first8=Roman |last9=Seth |first9=Prem |last10=Hartwigsen |first10=Jack |last11=Bhushan |first11=Reva |last12=Nicholls |first12=Joanna |last13=Jensen |first13=Steen |url-access=subscription }} (Co-author)
- {{cite journal |title=Gene therapy for liver metastases |journal=Seminars in Oncology |date=April 2002 |volume=29 |issue=2 |pages=202–208 |doi=10.1053/sonc.2002.31678 |pmid=11951219 |url=https://pubmed.ncbi.nlm.nih.gov/11951219/ |issn=0093-7754 |last1=Havlik |first1=Roman |last2=Jiao |first2=Long R. |last3=Nicholls |first3=Joanna |last4=Jensen |first4=Steen Lindkaer |last5=Habib |first5=Nagy A. }} (Co-author)
- {{Cite journal|date=December 2006|title=A modified radiofrequency-assisted approach to right hemihepatectomy|url=https://linkinghub.elsevier.com/retrieve/pii/S0748798306002800|journal=European Journal of Surgical Oncology|language=en|volume=32|issue=10|pages=1209–1211|doi=10.1016/j.ejso.2006.07.013|last1=Ferko |first1=A. |last2=Leško |first2=M. |last3=Šubrt |first3=Z. |last4=Melichar |first4=B. |last5=Hoffman |first5=P. |last6=Dvořák |first6=P. |last7=Vacek |first7=Z. |last8=Liao |first8=L.R. |last9=Habib |first9=N.A. |last10=Kočí |first10=J. |last11=Motyčka |first11=P. |pmid=16950592 |url-access=subscription }} (Co-author)
=Books=
- {{cite book |title=Hepatocellular Carcinoma: Methods and Protocols[ |date=2000 |publisher=Springer |location=Totowa |isbn=978-1-59259-079-7 |url=https://books.google.com/books?id=XZC8ECUFfUEC&q=habib+adenovirus+and+plasmid+liver+cancer |language=en}}
References
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Category:21st-century British medical doctors
Category:Egyptian emigrants to England
Category:Physicians from Cairo
Category:Physicians of Hammersmith Hospital