Naphthomycin

{{Short description|Class of chemical compounds}}

Naphthomycins are a group of closely related antimicrobial chemical compounds isolated from Streptomyces. They are considered a subclass of ansamycins.

Members include:

  • Naphthomycin A{{cite journal |author1=Balerna, M. |author2=Keller-Schierlein, W. |author3=Martius, C. |author4=Wolf, H. |author5=Zähner, H. |journal=Arch. Mikrobiol. |title=Metabolic products of microorganisms. 72. Naphthomycin, an antimetabolite of vitamin K |volume=65 |pages=303–17 |year=1969 |pmid=4988744 |issue=4 |doi=10.1007/BF00412210|s2cid=31145406 }}{{cite journal | title = Naphthomycin, a novel ansa macrocyclic metabolite. Proton NMR spectra and structural elucidation using lanthanide shift reagent | journal = J Antibiot | volume = 28 | pages = 85–86 | year = 1975 | doi = 10.7164/antibiotics.28.85 | pmid = 805115 | last1 = Williams | first1 = TH | issue = 1| doi-access = free }}
  • Naphthomycin B{{cite journal | pmid = 6874565 | year = 1983 | last1 = Keller-Schierlein | first1 = W | last2 = Meyer | first2 = M | last3 = Zeeck | first3 = A | last4 = Damberg | first4 = M | last5 = Machinek | first5 = R | last6 = Zähner | first6 = H | last7 = Lazar | first7 = G | title = Isolation and structural elucidation of naphthomycins B and C | volume = 36 | issue = 5 | pages = 484–92 | journal = The Journal of Antibiotics | doi=10.7164/antibiotics.36.484| doi-access = free }}
  • Naphthomycin C
  • Naphthomycin D
  • Naphthomycin E
  • Naphthomycin F
  • Naphthomycin G
  • Naphthomycin H{{cite journal | pmid = 4030505 | year = 1985 | last1 = Mukhopadhyay | first1 = T | last2 = Franco | first2 = CM | last3 = Reddy | first3 = GC | last4 = Ganguli | first4 = BN | last5 = Fehlhaber | first5 = HW | title = A new ansamycin antibiotic, naphthomycin H from a Streptomyces species Y-83,40369 | volume = 38 | issue = 7 | pages = 948–51 | journal = The Journal of Antibiotics | doi=10.7164/antibiotics.38.948| doi-access = free }}
  • Naphthomycin I{{cite journal | pmid = 9820235 | year = 1998 | last1 = Hooper | first1 = AM | last2 = Rickards | first2 = RW | title = 3-amino-5-hydroxybenzoic acid in antibiotic biosynthesis. XI. Biological origins and semisynthesis of thionaphthomycins, and the structures of naphthomycins I and J | volume = 51 | issue = 9 | pages = 845–51 | journal = The Journal of Antibiotics | doi=10.7164/antibiotics.51.845| doi-access = free }}
  • Naphthomycin J
  • Naphthomycin K{{cite journal | doi = 10.1038/ja.2007.84 | title = A Novel Ansamycin, Naphthomycin K from Streptomyces sp | year = 2007 | last1 = Lu | first1 = Chunhua | last2 = Shen | first2 = Yuemao | journal = The Journal of Antibiotics | volume = 60 | issue = 10 | pages = 649–53 | pmid = 17965482| doi-access = free }}
  • Naphthomycin L{{cite journal | pmid = 22742732 | year = 2012 | last1 = Yang | first1 = YH | last2 = Fu | first2 = XL | last3 = Li | first3 = LQ | last4 = Zeng | first4 = Y | last5 = Li | first5 = CY | last6 = He | first6 = YN | last7 = Zhao | first7 = PJ | title = Naphthomycins L-N, ansamycin antibiotics from Streptomyces sp. CS | volume = 75 | issue = 7 | pages = 1409–13 | doi = 10.1021/np300109s | journal = Journal of Natural Products}}
  • Naphthomycin M
  • Naphthomycin N

Chemical structures

File:Naphthomycin A.svg|Naphthomycin A

File:Naphthomycin B.svg|Naphthomycin B

File:Naphthomycin C.svg|Naphthomycin C

File:Naphthomycin D.svg|Naphthomycin D

File:Naphthomycin E.svg|Naphthomycin E

File:Naphthomycin F.svg|Naphthomycin F

File:Naphthomycin G.svg|Naphthomycin G

References