NeuroD
{{Short description|Basic helix-loop-helix transcription factor}}
NeuroD, also called Beta2, is a basic helix-loop-helix transcription factor expressed in certain parts of brain, beta pancreatic cells and enteroendocrine cells. It is involved in the differentiation of nervous system and development of pancreas.{{cite journal |last1=Gu |first1=Chunyan |last2=Stein |first2=Gretchen H. |last3=Pan |first3=Ning |last4=Goebbels |first4=Sandra |last5=Hörnberg |first5=Hanna |last6=Nave |first6=Klaus-Armin |last7=Herrera |first7=Pedro |last8=White |first8=Peter |last9=Kaestner |first9=Klaus H. |last10=Sussel |first10=Lori |last11=Lee |first11=Jacqueline E. |title=Pancreatic β Cells Require NeuroD to Achieve and Maintain Functional Maturity |journal=Cell Metabolism |date=7 April 2010 |volume=11 |issue=4 |pages=298–310 |doi=10.1016/j.cmet.2010.03.006 |pmid=20374962 |pmc=2855640 |language=en |issn=1550-4131|doi-access=free }} It heterodimerizes with the products of E2A gene and controls the transcription of a variety of genes by identifying and binding E boxes in their promoter region. In rodents NeuroD is involved in the development of the retina.{{cite journal |last1=Morrow |first1=E.M. |last2=Furukawa |first2=T. |last3=Lee |first3=J.E. |last4=Cepko |first4=C.L. |title=NeuroD regulates multiple functions in the developing neural retina in rodent |journal=Development |date=1 January 1999 |volume=126 |issue=1 |pages=23–36 |doi=10.1242/dev.126.1.23 |pmid=9834183 |url=https://journals.biologists.com/dev/article/126/1/23/40223/NeuroD-regulates-multiple-functions-in-the |access-date=1 March 2022|url-access=subscription }}
In mammals there are two types of this factor: