Neutrophil cytosolic factor 1

The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease.

Genetic variability in the NCF1 gene has been found to be related to a higher chance of getting autoimmune diseases such as Sjögren's syndrome, rheumatoid arthritis and lupus erythematosus.{{Cite news|url=https://medicalxpress.com/news/2017-02-complex-genetic-region-hidden-role.html|title=Study of complex genetic region finds hidden role of NCF1 in multiple autoimmune diseases|date=2017-02-08|newspaper=Medical Express|access-date=2017-02-09}}

Neutrophil cytosolic factor 1 has been shown to interact with:

• Moesin,{{cite journal | vauthors = Wientjes FB, Reeves EP, Soskic V, Furthmayr H, Segal AW | title = The NADPH oxidase components p47(phox) and p40(phox) bind to moesin through their PX domain | journal = Biochem. Biophys. Res. Commun. | volume = 289 | issue = 2 | pages = 382–8 | date = Nov 2001 | pmid = 11716484 | doi = 10.1006/bbrc.2001.5982 }}
• Neutrophil cytosolic factor 4,{{cite journal | vauthors = Lapouge K, Smith SJ, Groemping Y, Rittinger K | title = Architecture of the p40-p47-p67phox complex in the resting state of the NADPH oxidase. A central role for p67phox | journal = J. Biol. Chem. | volume = 277 | issue = 12 | pages = 10121–8 | date = Mar 2002 | pmid = 11796733 | doi = 10.1074/jbc.M112065200 | doi-access = free }}{{cite journal | vauthors = Grizot S, Grandvaux N, Fieschi F, Fauré J, Massenet C, Andrieu JP, Fuchs A, Vignais PV, Timmins PA, Dagher MC, Pebay-Peyroula E | title = Small angle neutron scattering and gel filtration analyses of neutrophil NADPH oxidase cytosolic factors highlight the role of the C-terminal end of p47phox in the association with p40phox | journal = Biochemistry | volume = 40 | issue = 10 | pages = 3127–33 | date = Mar 2001 | pmid = 11258927 | doi = 10.1021/bi0028439}}{{cite journal | vauthors = Sathyamoorthy M, de Mendez I, Adams AG, Leto TL | title = p40(phox) down-regulates NADPH oxidase activity through interactions with its SH3 domain | journal = J. Biol. Chem. | volume = 272 | issue = 14 | pages = 9141–6 | date = Apr 1997 | pmid = 9083043 | doi = 10.1074/jbc.272.14.9141| doi-access = free }} and
• RELA.{{cite journal | vauthors = Gu Y, Xu YC, Wu RF, Nwariaku FE, Souza RF, Flores SC, Terada LS | title = p47phox participates in activation of RelA in endothelial cells | journal = J. Biol. Chem. | volume = 278 | issue = 19 | pages = 17210–7 | date = May 2003 | pmid = 12618429 | doi = 10.1074/jbc.M210314200 | doi-access = free }}

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{{PDB Gallery|geneid=653361}}

{{NADH or NADPH oxidoreductases}}

{{protein-stub}}