NicO transporters

Homologues of the NicO family have differing predicted topologies: 6, 7 and 8 TMSs. One such homologue, RcnA (YohM; [http://www.tcdb.org/search/result.php?tc=2.A.113.1.1 TC# 2.A.113.1.1]) of E. coli (274 aas) has 6 putative transmembrane segments (TMSs) in a 3 + 3 arrangement with a large hydrophilic loop between putativeTMSs 3 and 4. Several homologues of RcnA (e.g., RcnA homologue from Ralstonia solanacearum; [http://www.tcdb.org/search/result.php?tc=2.A.113.1.3 TC# 2.A.113.1.3]; CAD17703) have 7 putative TMSs (4 + 3). Still another homologue, UreH of Methanocaldococcus janaschii ([http://www.tcdb.org/search/result.php?tc=2.A.113.1.4 TC# 2.A.113.1.4]) has 6 putative TMSs in a more characteristic 3 + 3 TMS arrangement. The NicO family within the LysE superfamily may have a common origin with the TOG superfamily, having lost TMSs 1 and 4 in the 8 TMS TOG superfamily topology.{{Cite web|title=The Nickel/cobalt Transporter (NicO) Family|url=http://www.tcdb.org/search/result.php?tc=2.A.113|access-date=2016-02-29|website=Transporter Classification Database}}

This protein is believed to catalyze Co²⁺ and Ni²⁺ efflux.{{Cite journal

| last1 = Rodrigue

| first1 = Agnès

| last2 = Effantin

| first2 = Géraldine

| last3 = Mandrand-Berthelot

| first3 = Marie-Andrée

| date = 2005-04-15

| title = Identification of rcnA (yohM), a Nickel and Cobalt Resistance Gene in Escherichia coli

| journal = Journal of Bacteriology

| language = en

| volume = 187

| issue = 8

| pages = 2912–2916

| doi = 10.1128/JB.187.8.2912-2916.2005

| issn = 0021-9193

| pmc = 1070376

| pmid = 15805538

}}

The overall reaction catalyzed by proteins of the NicO family is probably:

[Ni²⁺ or Co²⁺] (in) → [Ni²⁺ or Co²⁺] (out).

• NiCoT family, family of nickel/cobalt transporters within the TOG superfamily
• Nickel
• Cobalt
• Transporter Classification Database
• Transport protein

• Iwig, Jeffrey S.; Rowe, Jessica L.; Chivers, Peter T. (2006-10-01). [http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2958.2006.05369.x/abstract "Nickel homeostasis in Escherichia coli – the rcnR-rcnA efflux pathway and its linkage to NikR function"]. Molecular Microbiology 62 (1): 252–262.doi:10.1111/j.1365-2958.2006.05369.x. ISSN [https://www.worldcat.org/issn/1365-2958 1365-2958].
• Marrero, Jeannette; Auling, Georg; Coto, Orquidea; Nies, Dietrich H. (2007-01-01). [https://www.ncbi.nlm.nih.gov/pubmed/17186148 "High-level resistance to cobalt and nickel but probably no transenvelope efflux: Metal resistance in the Cuban Serratia marcescens strain C-1"]. Microbial Ecology 53 (1): 123–133. doi:10.1007/s00248-006-9152-7. ISSN [https://www.worldcat.org/issn/0095-3628 0095-3628]. PMID [https://www.ncbi.nlm.nih.gov/pubmed/17186148 17186148].
• Protchenko, Olga; Rodriguez-Suarez, Roberto; Androphy, Rachel; Bussey, Howard; Philpott, Caroline C. (2006-07-28). [https://www.ncbi.nlm.nih.gov/pubmed/16717099 "A screen for genes of heme uptake identifies the FLC family required for import of FAD into the endoplasmic reticulum"]. The Journal of Biological Chemistry 281 (30): 21445–21457.doi:10.1074/jbc.M512812200. ISSN [https://www.worldcat.org/issn/0021-9258 0021-9258].PMID [https://www.ncbi.nlm.nih.gov/pubmed/16717099 16717099].

{{reflist}}

• [http://www.tcdb.org/search/result.php?tc=2.A.113 The Nickel/Cobalt Transporter Family] Transporter Classification Database

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Category:Protein families

Category:Membrane proteins

Category:Transmembrane proteins

Category:Transmembrane transporters

Category:Transport proteins

Category:Integral membrane proteins

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