Nick Hoogenraad

{{Short description|Australian biochemist}}

{{Use Australian English|date=January 2024}}

{{Use dmy dates|date=January 2024}}

{{Infobox scientist

| birth_name = Nicolaas Johannes Hoogenraad

| birth_place = The Hague, Netherlands

| fields = Agricultural biochemistry
Medical biochemistry
Mitochondrial biochemistry

| workplaces = University of Melbourne
Stanford University
La Trobe University

| alma_mater = University of Melbourne

| thesis_title = Studies on the Contribution of Rumen Bacteria to the Nutritional Requirements of Sheep

| thesis_year = 1969

| doctoral_advisor = Frank Hird

| awards = ASBMB Lemberg Medal
AMRAD/Pharmacia Biotechnology Medal
Leach Protein Chemistry Medal
Officer of the Order of Australia

| website = https://scholars.latrobe.edu.au/njhoogenraad

| children = 2

}}

Nick Hoogenraad, {{post-nominals|country=AUS|AO}} is an Australian biochemist.{{Cite web |date=2014-06-08 |title=Queen's Birthday honours: full list |url=https://www.smh.com.au/national/queens-birthday-honours-full-list-20140608-39rfw.html |access-date=2024-01-06 |website=The Sydney Morning Herald |language=en}} He is currently Emeritus Professor of Biochemistry at La Trobe University.{{Cite web |title=Nick Hoogenrad |url=https://scholars.latrobe.edu.au/njhoogenraad |url-status=live |archive-url=https://web.archive.org/web/20231118074121/https://scholars.latrobe.edu.au/njhoogenraad |archive-date=18 November 2023 |access-date=2024-01-06 |website=La Trobe University}} Hoogenraad's work led to the discovery of the mitochondrial unfolded protein response.Multiple sources:

• {{Cite journal |last1=Vögtle |first1=F.-Nora |last2=Meisinger |first2=Chris |date=2012 |title=Sensing Mitochondrial Homeostasis: the Protein Import Machinery Takes Control |url= |journal=Developmental Cell |language=en |volume=23 |issue=2 |pages=234–236 |doi=10.1016/j.devcel.2012.07.018 |doi-access=free|pmid=22898772 }}
• {{Cite journal |last1=Sugiura |first1=Ayumu |last2=McLelland |first2=Gian-Luca |last3=Fon |first3=Edward A |last4=McBride |first4=Heidi M |date=2014 |title=A New Pathway for Mitochondrial Quality Control: Mitochondrial-derived Vesicles |journal=The EMBO Journal |language=en |volume=33 |issue=19 |pages=2142–2156 |doi=10.15252/embj.201488104 |issn=0261-4189 |pmc=4282503 |pmid=25107473 |doi-access=free}}
• {{Cite journal |last1=Weissig |first1=Volkmar |last2=Edeas |first2=Marvin |date=2022 |title=Recent developments in mitochondrial medicine (part 2): Aging, longevity and microbiota |journal=4open |volume=5 |pages=5 |doi=10.1051/fopen/2022002 |issn=2557-0250 |doi-access=free}}
• {{Cite journal |last=Hoogenraad |first=Nick |date=2017 |title=A Brief History of the Discovery of the Mitochondrial Unfolded Protein Response in Mammalian Cells |url=http://link.springer.com/10.1007/s10863-017-9703-2 |journal=Journal of Bioenergetics and Biomembranes |language=en |volume=49 |issue=4 |pages=293–295 |doi=10.1007/s10863-017-9703-2 |pmid=28429159 |s2cid=207186696 |issn=0145-479X |url-access=subscription}}

Hoogenraad was born in The Hague to Ton and Lique Hoogenraad, and was one of six children.{{Cite news |date=2013-07-22 |title=Lique Hoogenraad Obituary |work=The Age}} Hoogenraad completed a bachelor of agricultural science, by the end of which time he had "fallen in love with biochemistry", partly due to reading The Origin of Life by Soviet biochemist Alexander Oparin.{{Cite web |title=Professor Nick Hoogenraad, biochemist {{!}} Australian Academy of Science |url=https://www.science.org.au/learning/general-audience/history/interviews-australian-scientists/professor-nick-hoogenraad |access-date=2024-01-08 |website=www.science.org.au |language=en}} He completed his Ph.D. under agricultural biochemist Frank Hird, using biochemical and electron microscopy techniques to compile the first atlas of the bacteria in the rumen of sheep. Working with the rumen bacteria was unpleasant and another member of Hird's lab, Max Marginson, started calling Hoogenraad "rumencrud" in allusion to this. This behaviour stopped after Hoogenraad placed some foul-smelling butyric acid on Marginson's jacket.

He began work as a postdoctoral researcher in the Pediatric department at Stanford University in 1969, becoming assistant professor in Human Biology in 1971, and returning for a year as visiting professor in 1979. He returned to Australia in 1974 after being hired by Bruce Stone to join the new department of Biochemistry at La Trobe University. He became Head of Biochemistry when Stone retired in 1993. In 1998 he was appointed Head of the School of Molecular Sciences which was restructured multiple times, and by his retirement in 2014 contained three departments: Biochemistry and Genetics, Chemistry and Physics, and Pharmacy and Applied Science. Hoogenraad also served as the founding director of the La Trobe Institute for Molecular Science from 2009 to 2014.{{Cite web |last=University |first=La Trobe |title=Ten years of world-class research |url=https://www.latrobe.edu.au/news/announcements/2019/ten-years-of-world-class-research |access-date=2024-01-08 |website=www.latrobe.edu.au |language=en-AU}} An auditorium in the LIMS1 building is named after him.{{Cite book |last=Hoogenraad |first=Nick |url=https://www.latrobe.edu.au/__data/assets/pdf_file/0006/1007790/Biochemistry-at-LTU.pdf |title=Biochemistry at La Trobe University: A Proud History |date=2017 |publisher=La Trobe University |location=Bundoora}}

His most recent research interest is cachexia.{{Cite web |date=2021-11-30 |title=Programme 2024 - SCWD |url=https://society-scwd.org/annual-conference/programme/ |access-date=2024-01-17 |language=en-US}} In 2015 his team published research showing how mice that do not have the receptor for a protein called Fn14 do not develop cachexia in cancer. Mice treated with anti-Fn14 antibodies also do not develop cachexia.{{Cite web |date=2015-09-28 |title=How to stop cancer patients wasting away |url=https://cosmosmagazine.com/science/biology/how-to-stop-cancer-patients-wasting-away/ |access-date=2024-02-05 |website=cosmosmagazine.com |language=en-AU}}