Nishith Gupta

Nishith Gupta was born in Shahjahanpur, Uttar Pradesh, India. He pursued his early education at the Rohilkhand university (BS), Banaras Hindu University (MS) and later obtained his PhD in biochemistry from Leipzig University (Germany) in 2003.{{Cite web |title=Group Leader |url=https://universe.bits-pilani.ac.in/Hyderabad/guptanishith/Profile |access-date=2023-08-05 |website=universe.bits-pilani.ac.in}} Afterward, he was a post-doctoral fellow at the National Jewish Medical Center in Denver, United States. In 2009, he became a research group leader at the Humboldt University and affiliate scientist at the Max Planck Institute for Infection Biology in Berlin.{{Cite web |title=PD Nishith Gupta - Research Portal of the HU Berlin - Research Information System of HU Berlin |url=https://fis.hu-berlin.de/converis/portal/detail/Person/400063027?auxfun=&lang=en_GB |access-date=2023-11-30 |website=fis.hu-berlin.de}}{{Cite journal |last1=Arroyo-Olarte |first1=Ruben D. |last2=Brouwers |first2=Jos F. |last3=Kuchipudi |first3=Arunakar |last4=Helms |first4=J. Bernd |last5=Biswas |first5=Aindrila |last6=Dunay |first6=Ildiko R. |last7=Lucius |first7=Richard |last8=Gupta |first8=Nishith |date=2015-11-13 |title=Phosphatidylthreonine and Lipid-Mediated Control of Parasite Virulence |journal=PLOS Biology |language=en |volume=13 |issue=11 |pages=e1002288 |doi=10.1371/journal.pbio.1002288 |pmid=26565995 |issn=1545-7885|pmc=4643901 |doi-access=free }} In 2017, he was awarded Doctor habilitatus (DSc) by Humboldt University in the field of biochemistry and molecular parasitology.{{Cite web |last=nowotnch |title=Dr. Nishith Gupta |url=https://www.biologie.hu-berlin.de/de/gruppenseiten/molpara/Forschung/Metabolismus |access-date=2023-08-05 |website=Biologie HU Berlin |language=en}} In 2020, he returned to India, joining BITS Pilani as a Professor in the Department of Biological Sciences at the Hyderabad campus.

Nishith Gupta's research focuses on metabolic interactions between intracellular parasites and host cells.{{Cite web |title=Nishith Gupta |url=https://scholar.google.com/citations?user=hLsG-y4AAAAJ&hl=en |access-date=2023-08-05 |website=scholar.google.com}}{{Cite web |title=ORCID |url=https://orcid.org/0000-0003-1452-5126 |access-date=2023-08-11 |website=orcid.org}}{{Cite web |title=Nishith Gupta's schedule for The EMBO Meeting |url=https://theembomeeting2012.sched.com/speaker/nishithgupta |access-date=2023-08-11 |website=theembomeeting2012.sched.com}} His group has published several research articles focusing on carbon metabolism, membrane biogenesis and signaling pathways primarily in a widespread model parasite Toxoplasma gondii, but also in Plasmodium, and Eimeria species.{{Cite web |date=2017-03-23 |title=Nishith Gupta |url=https://www.vetmed.fu-berlin.de/en/einrichtungen/sonstige/grk2046/members/2_-senior_researchers/gupta/index.html |access-date=2023-08-05 |website=www.vetmed.fu-berlin.de |language=en}}{{Cite web |title=DFG – GEPRIS – Dr. Nishith Gupta |url=https://gepris.dfg.de/gepris/person/99735262?language=en |access-date=2023-08-05 |website=gepris.dfg.de}}{{Cite web |title=IISER Pune |url=http://www3.iiserpune.ac.in/colloquia-seminars/860 |access-date=2023-08-07 |website=www3.iiserpune.ac.in}}

Gupta's research on membrane biogenesis in apicomplexan parasites, involving the discovery of unique phospholipids, holds potential for advancing the development of vaccines against parasitic diseases.{{Cite journal |last1=Ren |first1=Bingjian |last2=Kong |first2=Pengfei |last3=Hedar |first3=Fatima |last4=Brouwers |first4=Jos F. |last5=Gupta |first5=Nishith |date=2020-12-10 |title=Phosphatidylinositol synthesis, its selective salvage, and inter-regulation of anionic phospholipids in Toxoplasma gondii |journal=Communications Biology |language=en |volume=3 |issue=1 |page=750 |doi=10.1038/s42003-020-01480-5 |issn=2399-3642 |pmc=7728818 |pmid=33303967}}{{Cite journal |last=Gupta |first=Nishith |date=22 April 2005 |title=Selective disruption of phosphatidylcholine metabolism of the intracellular parasite Toxoplasma gondii arrests its growth |url=https://www.jbc.org/article/S0021-9258(20)69317-6/fulltext |journal=Journal of Biological Chemistry |volume=280 |issue=16 |pages=16345–16353 |doi=10.1074/jbc.M501523200 |pmid=15708856 |doi-access=free}} Notably, his work on phosphatidylcholine, phosphatidylinositol and phosphatidylethanolamine identified potential therapeutic targets, while phosphatidylthreonine and a novel phosphatidylserine decarboxylase could serve as toxoplasmosis biomarkers.{{Cite journal |last1=Gupta |first1=Nishith |last2=Hartmann |first2=Anne |last3=Lucius |first3=Richard |last4=Voelker |first4=Dennis R. |date=2012-06-29 |title=The obligate intracellular parasite Toxoplasma gondii secretes a soluble phosphatidylserine decarboxylase |journal=The Journal of Biological Chemistry |volume=287 |issue=27 |pages=22938–22947 |doi=10.1074/jbc.M112.373639 |issn=1083-351X |pmc=3391113 |pmid=22563079 |doi-access=free}}

In collaboration with researchers at the University of Melbourne{{Cite web |title=Toxoplasma parasite's greedy appetite may be its downfall |url=https://www.sciencedaily.com/releases/2015/08/150812131443.htm |access-date=2023-11-29 |website=ScienceDaily |language=en}} and National Key Laboratory of Agricultural Microbiology in Wuhan,{{Cite web |title=Shen Bang-农业微生物资源发掘与利用全国重点实验室 |url=https://hzaml.hzau.edu.cn/info/1171/2447.htm |access-date=2023-11-29 |website=hzaml.hzau.edu.cn |language=en}}{{Cite web |title=国家自然科学基金委员会中德科学中心2020年度中德合作交流项目批准通知 |url=https://www.nsfc.gov.cn/publish/portal0/tab1362/info86379.htm |access-date=2024-06-15 |website=www.nsfc.gov.cn}} Gupta's group has revealed Toxoplasma's metabolic adaptability and identified proteins crucial for the parasite's development, suggesting potential drug targets for toxoplasmosis and related infections.{{Cite journal |last1=Blume |first1=Martin |last2=Rodriguez-Contreras |first2=Dayana |last3=Landfear |first3=Scott |last4=Fleige |first4=Tobias |last5=Soldati-Favre |first5=Dominique |last6=Lucius |first6=Richard |last7=Gupta |first7=Nishith |date=2009-08-04 |title=Host-derived glucose and its transporter in the obligate intracellular pathogen Toxoplasma gondii are dispensable by glutaminolysis |journal=Proceedings of the National Academy of Sciences |language=en |volume=106 |issue=31 |pages=12998–13003 |doi=10.1073/pnas.0903831106 |issn=0027-8424 |pmc=2722337 |pmid=19617561 |bibcode=2009PNAS..10612998B |doi-access=free }}{{Cite journal |last1=Nitzsche |first1=Richard |last2=Günay-Esiyok |first2=Özlem |last3=Tischer |first3=Maximilian |last4=Zagoriy |first4=Vyacheslav |last5=Gupta |first5=Nishith |date=2017-09-15 |title=A plant/fungal-type phosphoenolpyruvate carboxykinase located in the parasite mitochondrion ensures glucose-independent survival of Toxoplasma gondii |journal=Journal of Biological Chemistry |volume=292 |issue=37 |pages=15225–15239 |doi=10.1074/jbc.M117.802702 |pmid=28726641 |pmc=5602384 |issn=0021-9258 |doi-access=free }} In addition, his group uncovered Plasmodium's reliance on host-derived sugars, offering new directions for the development of anti-malarial drugs.{{Cite journal |last=Blume |first=Martin |date=April 2011 |title=A constitutive pan-hexose permease for the Plasmodium life cycle and transgenic models for screening of antimalarial sugar analogs |journal=The FASEB Journal |language=en |volume=25 |issue=4 |pages=1218–1229 |doi=10.1096/fj.10-173278 |doi-access=free |issn=0892-6638 |pmc=3058700 |pmid=21169382}}

In a pioneering collaboration with Peter Hegemann, Gupta's work in Optogenetic regulation of cyclic nucleotide signaling within Toxoplasma gondii has paved the way for broader applications of light-activated proteins and biosensors in other intracellular pathogens, including parasites, bacteria, and viruses.{{Cite journal |last1=Kuchipudi |first1=Arunakar |last2=Arroyo-Olarte |first2=Ruben D. |last3=Hoffmann |first3=Friederike |last4=Brinkmann |first4=Volker |last5=Gupta |first5=Nishith |date=2016-05-02 |title=Optogenetic monitoring identifies phosphatidylthreonine-regulated calcium homeostasis in Toxoplasma gondii |journal=Microbial Cell (Graz, Austria) |volume=3 |issue=5 |pages=215–223 |doi=10.15698/mic2016.05.500 |issn=2311-2638 |pmc=5349149 |pmid=28357357}}{{Cite journal |last1=Arroyo-Olarte |first1=Ruben Dario |last2=Thurow |first2=Laura |last3=Kozjak-Pavlovic |first3=Vera |last4=Gupta |first4=Nishith |date=2018-07-12 |title=Illuminating pathogen–host intimacy through optogenetics |journal=PLOS Pathogens |language=en |volume=14 |issue=7 |pages=e1007046 |doi=10.1371/journal.ppat.1007046 |issn=1553-7374 |pmc=6042787 |pmid=30001435 |doi-access=free}}{{Cite journal |last=Gupta |first=Nishith |date=10 May 2013 |title=Optogenetic Modulation of an Adenylate Cyclase in Toxoplasma gondii Demonstrates a Requirement of the Parasite cAMP for Host-Cell Invasion and Stage Differentiation |journal=Journal of Biological Chemistry |volume=288 |issue=19 |pages=13705–13717 |doi=10.1074/jbc.M113.465583 |pmc=3650408 |pmid=23525100 |doi-access=free}}

Throughout his career, Gupta has held leadership positions, including the Heisenberg Fellow of German Research Foundation (DFG) at the Humboldt University{{Cite web |title=CV Nishith Gupta – RWTH Aachen University spp2225 – English |url=https://www.spp2225.rwth-aachen.de/cms/spp2225/Projekte/Nishith-Gupta/~nfede/CV-Nishith-Gupta/?lidx=1 |access-date=2023-08-05 |website=www.spp2225.rwth-aachen.de}} and Senior Fellow of the Wellcome Trust-DBT (India Alliance). He is currently serving as the editorial board member of Animal Diseases,{{Cite web |title=Animal Diseases |url=https://animaldiseases.biomedcentral.com/about/editorial-board |access-date=2023-08-11 |website=BioMed Central |language=en}} Microbial Cell,{{Cite journal |date=1970-01-01 |title=Editorial Board |url=https://microbialcell.com/for-authors/editorial-board/ |journal=Microbial Cell |language=en |issn=2311-2638}} and Communications Biology published by Nature Portfolio.{{Cite web |title=Editorial Board {{!}} Communications Biology |url=https://www.nature.com/commsbio/editorial-board |access-date=2023-08-07 |website=www.nature.com |language=en}}

In 2021, he founded the [https://www.ipearl.org/ Intracellular Parasite Education and Research Labs (iPEARL)] in the Biological Science division of BITS Pilani and an integrated One Health initiative – Veterinary And Medical Parasite Infection Research Ensemble (VAMPIRE).{{Cite web |last=Gupta |first=Nishith |date=2022-12-01 |title=Prof. Nishith Gupta |url=https://www.bits-pilani.ac.in/hyderabad/prof-nishith-gupta/ |access-date=2023-11-28 |website=BITS Pilani |language=en-US}} These initiatives seek to support the development of future scientists and leaders and contribute to the advancement of our knowledge about parasitic infections in clinical and veterinary settings.{{Cite web |title=Instagram |url=https://www.instagram.com/p/CwAAp4VgeWz/ |access-date=2023-11-28 |website=www.instagram.com}}

In 2010 he was awarded ESCMID research grant for his contribution to the field of clinical microbiology and infectious diseases.{{Cite web |title=ESCMID: Awardees 2010 |url=https://www.escmid.org/profession-career/awards-grants/research-grants/previous-awardees/awardees-2010 |access-date=2023-08-11 |website=www.escmid.org}} In 2014, Nishith Gupta received with the Karl Asmund Rudolphi Medal, an award from the German Society for Parasitology.{{Cite web |title=Preise {{!}} Deutsche Gesellschaft für Parasitologie |url=https://dgparasitologie.de/preise |access-date=2023-08-05 |language=de-DE}} In 2015, he received the young scientist award in Microbiology from the Robert Koch Foundation.{{Cite web |last=Parasito |title=Postdoktorandenpreis für Dr. Nishith Gupta |url=https://www.biologie.hu-berlin.de/de/gruppenseiten/molpara/nachrichten/archiv/postdoktorandenpreis-fuer-dr-nishith-gupta |access-date=2023-08-05 |website=Biologie HU Berlin |language=de}}{{Cite web |title=Post-doctoral awards for young scientists |url=https://www.robert-koch-stiftung.de/en/awards/post-doctoral-awards-for-young-scientists |access-date=2023-08-05 |website=www.robert-koch-stiftung.de |language=en-en}} In 2020, he received the Outstanding Potential for Excellence in Research & Academics (OPERA) award from BITS Pilani.{{Cite web |last=BITS |first=Pilani |date=13 July 2020 |title=OPERA Award |url=http://sites.bits-hyderabad.ac.in/dload/BITSCAN%20Issue%2013.pdf }} Banaras Hindu University honoured him with distinguished alumni award in recognition of his achievements in academics and research.{{Cite web |title=Banaras Hindu University, [BHU], Varanasi-221005, U.P., India. – Banaras Hindu University, Varanasi, India. |url=https://bhu.ac.in/Site/Page/1_147_6505_Institute-of-Science-Alumni |access-date=2023-08-11 |website=bhu.ac.in}} In 2023, Indian Council of Medical Research awarded him an International Fellowships for Senior Biomedical Scientist in collaboration with the SickKids Hospital and University of Toronto.{{Cite web |last=DHR |first=ICMR |title=International Fellowships for Senior Indian Biomedical Scientist |url=https://main.icmr.nic.in/sites/default/files/whats_new/Selected_candidates_for_Short_Term_Fellowship.pdf |access-date=24 September 2023 |website=ICMR}}{{Cite web |title=Birla Institute of Technology and Science, Pilani on LinkedIn: #bits #bitspilani #bitshyderabad #icmr #dbt #biologicalsciences |url=https://www.linkedin.com/posts/birla-institute-of-technology-and-science-pilani_bits-bitspilani-bitshyderabad-activity-7051796295367233536-I6Mt |access-date=2023-09-24 |website=www.linkedin.com |language=en}}

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• [https://universe.bits-pilani.ac.in/Hyderabad/guptanishith/Profile Official Profile]

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Category:21st-century German biologists

Category:Molecular biologists

Category:Microbiologists

Category:Living people

Category:1977 births

Category:Leipzig University alumni

Category:German parasitologists

Category:Banaras Hindu University alumni

Category:21st-century Indian scientists

Category:21st-century Indian biologists